Conserved Protein Domain Family
PgaPase_1
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pfam06162: PgaPase_1 
Putative pyroglutamyl peptidase PgaPase_1
PgaPase_1 is a family of functionally diverse Caenorhabditis proteins. The family is homologous to the cysteine-peptidases, but lack of a strictly conserved Glu-Cys-His catalytic triad or pGlu binding site implies that it has other functions that could have resulted in a change in reaction-specificity or even of catalytic activity.
Links
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Statistics
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PSSM-Id: 310625
Aligned: 4 rows
Threshold Bit Score: 227.884
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9GYU2        13 MLSMCNKHPFFDDddse--rfviLYKICTVFDEPVEGKQPSSAVIVYEELAKSG-GYCCRPs-KMEESYVKVDQVVQEMA 88  Caenorhabditis ...
Q9GYU1         1 MLSMCNRQPFLMS----------LYSIFTVIDEPVEGKQPSSAVFVYEELAKFG-DFCKLF--KMEESYINVDQVVQEIA 67  Caenorhabditis ...
Q9XV94         1 MLSMCNKYPKFEDddmeryvitnPHDVVTVFDG-------SPAVIVFDELVKSD-TSKYLSf-KMEQSYGKVDEIAAKMV 71  Caenorhabditis ...
NP_001122498  13 ILTMCD----IPFphsrevvmikGIAIV-GFETSENATNPSNDVM--EQICSEQySDKMIFliKFPLSYDPLKQKIDELF 85 

Q9GYU2        89 KITSKCAIHLSSHALKNTIQIVRTAFSGEYTQNDKDGNVPEGNEVKFDGDETVMKTTVNCEKLVEDINEFMEEDRQMYGA 168 Caenorhabditis ...
Q9GYU1        68 NIQSRYAIHLSSHSLKNTIQIVRTAFPNGYTQNDKNGNVPEGNKVKFDGDETVMKTTVDCEQLVKDIKEFMEEDRQKYGE 147 Caenorhabditis ...
Q9XV94        72 TEEIHFTIHLCSHSQKNVIEIFQSAYSNGYTEKDKKGKIPEGGKVKCAGTETGARSKVNCEEVAKEVNERIDSAKDKFGE 151 Caenorhabditis ...
NP_001122498  86 ECPGVVAFHFETHLVKNTIYVEKKAFQSGYHQKDEKGYLPEGNKVSCESVDNTLETIIDCMDVVKKVTEKCGLDGVKFGG 165

Q9GYU2       169 LEIQIMEE 176 Caenorhabditis elegans
Q9GYU1       148 LEIQIIEE 155 Caenorhabditis elegans
Q9XV94       152 FWESGEVS 159 Caenorhabditis elegans
NP_001122498 166 LKVEVSED 173
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