2C1W


Conserved Protein Domain Family
XendoU
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cd21159: XendoU 
Xenopus laevis endoribonuclease XendoU, and related proteins
Xenopus laevis XendoU is a uridylate-specific endoribonuclease, which releases a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. XendoU is a monomer and requires Mn2+. It is involved in the processing of intron-encoded box C/D U16 small, nucleolar RNA. XendoU is distantly related to the Nidovirus uridylate-specific endoribonucleases (NendoUs) which include Nonstructural protein 15 (Nsp15) from coronaviruses, Nsp11 from arteriviruses, and torovirus endoribonuclease.
Links
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Statistics
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PSSM-Id: 394910
Aligned: 414 rows
Threshold Bit Score: 148.848
Created: 28-Mar-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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catalytic siteputative active
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 3 residue positions
Conserved feature residue pattern:H H KClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
2C1W_A          8 LNHELSKLFNELWDAdqnrm-----ksgkdYRISLQGkagyvp----------agsnqARDSASFPLFQFvd--eEKLKS 70   African clawe...
XP_002677457    5 SYQFSATLMDEIWQAdenr--------ltpVKIKPQGpiggey---------icvvcgMDRKRSNPNFTLf----KLYQY 63   Naegleria gru...
WP_149035754    9 ADMDGNGVLPLIKGVsdsdrn----dekgyVIVDMDPfsgr-------------ggrgERNREVNVLTNV-----TIPEE 66   Paenibacillus...
WP_127488621   47 LLPLIKGVSDDEKNEqq-----------gyVIVNQNPfpr----------------gqKRERSQTRQVNVle-evHIPDK 98   Paenibacillus...
PAA90982       50 KRSSAQEAMNELFTCllethvqntevfrlaRQIDFGGi-------------------aGNGVTQKPLLTRl---ySIAKV 107  Macrostomum l...
WP_150273296   14 KQNGLMPLIKDLSEHeaip-------eegyVVVDMNPfptg-------------npepRADQQVNVIKKV-----VIPEH 68   Paenibacillus...
OLP91865      895 ENIRTAKMADALQQEdgsavar--llackdILVDERP---------------------RQEGHEAPLFAQvq--pYVFTR 949  Symbiodinium ...
TNN10677        5 PRSLPLTILEKLSILfs------------dYFINHIKheyiyqllndiqweryiqqksKHTSMPYPLFPTnitpdYVFNE 72   Schistosoma j...
TPP61153       20 VLDELSMLFSHQFAKs--------------VKPDEIYveltr-----------ipwfrASDGTPLPLIPPrltpgRVFRT 74   Fasciola giga...
VDP71812       17 VLDELSMLFSHQFAQs--------------VKTDKVYvqlth-----------vpwlrNSDSTPLPLLPPqltpeTVFRS 71   Echinostoma c...

Feature 1                                                                                         
2C1W_A         71 Rk----------------------TFATFISLLDNYemdtgvaevvTPEEIAENNNFLDAILeTKVMKMAHDYLVrknqa 128  African clawe...
XP_002677457   64 DatkhvyvqvknseflqsnskqakNYKLISRLFDNYsldqhsrevnTEEERKEVEQFLESIVqTKCMRILGQKYMklst- 142  Naegleria gru...
WP_149035754   67 Km---------------------aSYNIFQKFHNNYdwhekendpvTEEEENEIRELLEFSIkTPPMKIVRDYALekkii 125  Paenibacillus...
WP_127488621   99 Kl---------------------eSYSLFKKLHDNYdwrrnkndetPQAELDEVNEFLNFAIkTAPMKIARDFAIdkgki 157  Paenibacillus...
PAA90982      108 Taa-------------------seSYRRYFDVVSIFtpelgqdevrGSNELALEAAYLAHLLsTPFIRDTYATLRannai 168  Macrostomum l...
WP_150273296   69 Kl---------------------iSYDLFKTLHDNYnwrrnqndptPQKEWDEIQNFLKFAItTAPMEIAREFAAskgyi 127  Paenibacillus...
OLP91865      950 S-----------------------TFLALLDVFEVFhqrrgqigeyTVDERGKIEKLLDVVDrTPVMRRARAEAAkledl 1006 Symbiodinium ...
TNN10677       73 Th---------------------iTIWKDILLKWNDs---------MIIRQELTDKFMEQIYqTTLFHRVYDCLQssnif 122  Schistosoma j...
TPP61153       75 E-----------------------MDMVTKDILLNWd---------RNERERLISNFLDHLFrTSNFREVYEILHarevy 122  Fasciola giga...
VDP71812       72 E-----------------------MDLATKEILLHWs---------ETHQGERIDNFLMHLFqTSNFRSVYEILNarsvy 119  Echinostoma c...

Feature 1                                                 #                   #                   
2C1W_A        129 k---ptrndFKVQLYNIWFqLYSRapgs----rpdSCGFEHVFVGESkr----gqEMMGLHNWVQFYLQEKRk------- 190  African clawe...
XP_002677457  143 ------pteLKVKLREIWFkQYNLhny------kdLSGFEHLVVGEKng-----dKVSGYHYWFKYLLDDSTdnht-gqd 204  Naegleria gru...
WP_149035754  126 sn-gtsdeeWLEQLKDIWFgQYQRn---------sTSAFEHIFMGEQkg-----tELNGHHFWYHYYINDGPfevthvrd 190  Paenibacillus...
WP_127488621  158 ss-tssdeaWINELKSIWFnQYRRn---------sTSAFEHVFIGEQge----egSLSGHHSWYHYHINDGPfevthqed 223  Paenibacillus...
PAA90982      169 daavslnqfVYGIMYDHWFkLYARtskahaagrreSSGFGHVFVGEVkt-----nDVTGFHSWLQLLLAETQg------- 236  Macrostomum l...
WP_150273296  128 sg-sasdeeWIDKLTDLWFaQYEGn---------sTSLFEHVFIGEEggtsgrdrVLSGHHFWYHYYINDGPfevttfed 197  Paenibacillus...
OLP91865     1007 -----tdesWRRHMWNIWFqRHPTs---------pKCGFEHVFVGEAtedlqgrgVVGGLHNWVKFYLEEQRg------- 1065 Symbiodinium ...
TNN10677      123 n---gdrlqFKDYFHQIWFhQYSWnqmst-ksisnTCGFQHVFIGDIyn-----sCVKGLHHWKRYYILERIgql---ql 190  Schistosoma j...
TPP61153      123 p---dsleeFGHCFRQVWFgLFSWdqmsp--gvnrTCGFQHVYIGEKra-----nKVKGLHNWMRYYILEKSar------ 186  Fasciola giga...
VDP71812      120 p---ynlseFEICFRQVWFgLYSWdqmsp--gsdiTCGFQHVYIGEKrr-----nTVKGLHNWMRYYILEKSak------ 183  Echinostoma c...

Feature 1                                                       #                                 
2C1W_A        191 nIDYKGYVArqnksr--pdeddqVLNLQFNWK-----------EMVKPv-GSSFIGVSPEFEFALYTIVFla-------- 248  African clawe...
XP_002677457  205 vISFAGRLDnes--------tpdYVCVRFKQDedvdgdgqsdnQLFKSc-GSFFVGISPECLLALSTLAYlesl------ 269  Naegleria gru...
WP_149035754  191 aIHFLKTVEvvraeq---shlaeVITIKYNYEevds---agnkTVLQKkkGGFFVGTSTEGLIALGTAAFf--------- 255  Paenibacillus...
WP_127488621  224 kIRFLEEVEvitsek---srkaeIITIKYIYSasde---ngrtDLMKSk-GGFFVGLSTEGLLAMGTVGFld-------- 288  Paenibacillus...
PAA90982      237 nFDYKGYVRiqds-------svlIGGIQFSWM-----------GRSKSl-SSVMFGVPPEFELALYSACFi--------- 288  Macrostomum l...
WP_150273296  198 sIAFLKHVEvvrsev---snlaeIITIKYIYTkkdg---sgelDLLKTpkGGFFVGLSTEGLLAMGTVAFled------- 264  Paenibacillus...
OLP91865     1066 aARYLGARYkgrttvsegalnpyFVSGRFTWDle-------gkHLIKDv-GGFFVGVSPEWQLAIATTAFfetltperav 1137 Symbiodinium ...
TNN10677      191 hNIYKKHSKl------------yISSMKFEVD-----------HCLKPy-GTIFFGLTIDFEILLYFCAFl--------- 237  Schistosoma j...
TPP61153      187 lVLSRVHKKhpn---------lqIASIRFTYD-----------EAVKPy-GTIFFGLPIQFEIMLFFCAFi--------- 236  Fasciola giga...
VDP71812      184 lVLNRVHKKhpv---------lpLASLRFIYD-----------EAVKPy-GTIFFGLPIQFEIMIFFCAFl--------- 233  Echinostoma c...

Feature 1                                                        
2C1W_A        249 ---------sqEKMSREVVRLE--EYELQIVVNRHg---RYIGTAYP 281  African clawed frog
XP_002677457  270 --------qpsGKKNLSDVKIN--GNRYVINVFNEg---GYPRSIYP 303  Naegleria gruberi strain NEG-M
WP_149035754  256 -----------DGRENVPIELN--GEKYDLAVFKAqddpTKLRTFFP 289  Paenibacillus polymyxa
WP_127488621  289 ----------pKQRAAIPFVLN--GENYSMTVWKTqdnrQDPRTFFP 323  Paenibacillus ehimensis
PAA90982      289 ----------vNPGRRTNLSIK--GRPVSVQTFYVnhqpESVATAYP 323  Macrostomum lignano
WP_150273296  265 ---------vnDTDVYLKFDLN--GERYSLTVWRTkdnhKHPRTFFP 300  Paenibacillus sp. SYSU G01001
OLP91865     1138 rrqwsrdfmsrDVGYMRAARLGdhVYRICIRRNEH----GNLTTFFA 1180 Symbiodinium microadriaticum
TNN10677      238 ----------iNVNRQVNFIID--NEQITVVCYDVamqnNALATAFI 272  Schistosoma japonicum
TPP61153      237 ----------iGGSREVNFLID--GQRTAVISYDVatqnNMLATAFF 271  Fasciola gigantica
VDP71812      234 ----------iGGSREVNFLID--GQKTTVISYDVatrtDALATAFF 268  Echinostoma caproni

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