Conserved Protein Domain Family
MOLO1

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pfam17175: MOLO1 
Modulator of levamisole receptor-1
MOLO1 is a one-pass transmembrane protein that contains a single extracellular globular domain. It is a positive regulator of levamisole-sensitive acetylcholine receptors in Caenorhabditis elegans, UniProtKB:Q19280. These receptors are Cys-loop ligand-gated ion channels, and the MOLO1 domain is an auxiliary subunit of the gated channel. The proteins carry a Rossmann fold.
Statistics
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PSSM-Id: 435767
Aligned: 20 rows
Threshold Bit Score: 105.958
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q19280        21 WTSSQFPDLRGPTVNqCVA----VLPrnkqqlYVCDPDHMLNNTQAMQLNIQLQELAVGTPC-----------HCQRRSQ 85  Caenorhabditis ...
Q8I456        70 YDENSFPDPFTHPEE-CVLslgiSHT------WLCDPSRFLSIEQQINIEAELLKIRDTNFH-----------KCSNN-- 129 Plasmodium falc...
EDO06785      68 TTLENYPDPFVNPRE-CNRpd-aTES------YICDPDHLLTKVEADRIDELLSLQRHDSQH-----------HCEGL-- 126
CAX63932      59 ITLENFPNPFFHPSL-CNRyg-fKFS------YICDPNKILSRNIADQIEEILNYQRRNSKH-----------FCVDK-- 117
XP_002258246  68 VTLENFPNPFIHPSL-CNRng-lSYS------YLCDPNKILSRSTADKIEEILSYQRRNSSH-----------YCADR-- 126
PDM77073     204 WKRTAFPNPMRGEHVkCGLk---EAG------PFCDPDGIFDEEEREVILGNLAIFEEQTRHspvavshnastFCRDRg- 273
XP_002590519  23 WEKENYPNPQLQPEL-CSPsv-gKPS------WLCNPDHVLNEHSALMLREKLKLVHEEAKC-----------FCDDCTD 83 
EKC18398      24 WRVTDFPHPVYQAKQ-CGRk---EAS------WICDPNGIISTQDADAIQQTVKETYDSTQC-----------PCPECAA 82 
PDM84294      22 WTPESYPDPRVNFTQ-CNVa---SES------FVCDPDHILTDNWRETIDVNVKRQIQRLAEspvfytdsapsECYSNET 91 
Q17845        13 WEPLTYPDPRTNSTE-CNVp---HDG------TLCDPDHILTDTWRQTILDNIEKQMAKLETakihytdkanpECFLNST 82  Caenorhabditis ...
Q19280        86 CttgiegsggkegLhgfIVSIAIVKNLYMHMHSP---SdtQLTERAEAFCRALEGRWALG--DCGNSVIVFVWQHYK 157 Caenorhabditis ele...
Q8I456       130 S------------VyyyQVSVAIVPEIFVSKNE-------TYENAAQQFSEKLLRKWGIGnsPCHDGILLVYIKNLG 187 Plasmodium falcipa...
EDO06785     127 G------------SvpyRLGVAIINWL--------------PAEDMPTLSNELLKRWRLSheKCSDGVLILYVIRHN 177
CAX63932     118 -------------EvpyVLGVALINKL-------------PYGISADTFASQIFEYWKLSnkDCNDGVLLFFVKEDT 168
XP_002258246 127 G------------EvpyVLGVALIERL-------------PYGVSAETFSSQILEHWKLGnrNCNDGILLLFVKENA 178
PDM77073     274 ----------------ySMGLAVMRKVEGTYNRNpsnFpgGTQKKLTELAHYMINTWKLDe-kCGKQFIMAISIDDG 333
XP_002590519  84 -------------RggyTIAVATMQQMEPMYWTLlptEqvPVNISSRRYARFLRDAWFPDq-SCTDHVIILVSKLDD 146
EKC18398      83 N------------NqgyVIMVAIMPRMYRIVNRSa--NvqDVLYDARVYSYYLSQFWNVT--TCDTNTLLLYSKDDD 143
PDM84294      92 qp--------------vEIFVLLAKRIHTANNQT---V---NETDMTTFVDGLADSFGLAnlTCANFVVLVGVEQAN 148
Q17845        83 gp--------------pQIFLILAKRIHAASNQS---Y---VRSDLTKFGDGIREAFGLNemPCQNHVLISGVELAK 139 Caenorhabditis ele...
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