Conserved Protein Domain Family
DUF316

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pfam03761: DUF316 
Nematode trypsin-6-like family
This is a family of trypsin-6-like proteins found in nematodes that are part of the chymotrypsin family S1, ie a serine peptidase. The C. elegans sequence UniProt:O01566 is trypsin-6: all the active site residues are present (His90, Asp168, Ser267).
Statistics
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PSSM-Id: 367641
Aligned: 9 rows
Threshold Bit Score: 297.029
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O76649         2 NIGILISLLFLGFSSSRIIGEKENQVLQSYCG-RTPFLQRRI---------INGKPLEAFENPWAVAAQFQYYVQKDGKP 71  Caenorhabditis ...
Q21628         5 SLTYIFVIINIGLVVGLNFTDAEVANLRASCKnKTLPPNNQQng-----htGVSLHGQNESYQWLVRVRLKDGTEGKDLY 79  Caenorhabditis ...
O45371         3 FLTLFIWIIACGFNNTQPLSYEENIQRLESCG-KILPEES-----------SNSITKSKYFKNWFGIAAFQNGNQYNFRT 70  Caenorhabditis ...
O62223         7 IIFYFIFVIAIIPIVTEKLSLKENKERLNTCGk------------------DKDIYNGIKNNRWHILAAFENGNNIEYIS 68  Caenorhabditis ...
CAP22195       3 LLHLLPLVVFVVGVGAGKISEQENEQTQLICGkKADGYSRKV---------INGEYVKKGEHPWAVSVYTRYYDEKNESQ 73 
XP_002640478  15 ILIGIFSILIGSSEPFRKLSPDENQSRLKSCGnFKLPQHSQD---------ANGVIITKEPYELNNVVTFTACTIQQAFA 85 
O62231         5 VIVIFFALTGCIGCDFYKLTADENKDRASTCGkEVLERKG-----------NETTPANVSQTDWTLKMHNIDHNPDRYY- 72  Caenorhabditis ...
Q9XWZ8         4 QSIITISTFIIIVVSYNELTAEENDKRLETCGnEHIGKPSKN--------------SIISPVSWLTKLTRSEISA----- 64  Caenorhabditis ...
Q9U2W2         6 IGVLVFIGIVNCLISSQKLTVKENEERLKSCGnTFLPIPSINqtgkgfgffNDKTYTYNSKSGWLLLAGHKNRSTRVYA- 84  Caenorhabditis ...
O76649        72 krlvmvfPGTVISPYHILTYNLVRSYDGV---FGfqhKENMTSNGTCLGE--HYFLPEEYTDRFDIim--drSKFDMTRK 144 Caenorhabditis ...
Q21628        80 d-----sGGSFISTRHVMANSQSISTGKKkwaLNgadIGSSCNNDPVMGSlgIEEVPSDVVDKMEV------VIEKCQNS 148 Caenorhabditis ...
O45371        71 -------VGTFISKRHFLTLAYALMNSNMtwrA-----KHTKFRDSCVSGmeDSIVPPEVVADLKIfv---cPNGKGKHC 135 Caenorhabditis ...
O62223        69 -------SASLISNRHFITSAFSILNSQMewlMN----KEKLDYTACSKGalSLRIPMQFLRNLTIre---vSCQIWGSC 134 Caenorhabditis ...
CAP22195      74 fi---ygPGTMISSRHIIKFNSLFYSTKN---LNlsgREYTGYKGICEGD--NLIVPQELLSRFDVdle-ylNDMNGNRE 144
XP_002640478  86 -------TATAISSRHILTSSHVFIDGRRk-------wRWTGQSVQCSAGsaDLDVPSEVLKSIDR-------------- 137
O62231        73 -------LATMISTRHVLTSARLVR-NESg--------wRDGSRDECDGK--NLVVPPSLLEKVEIpqhaqdGSKSVSNS 134 Caenorhabditis ...
Q9XWZ8        65 -------PAVIISPRHLITSSRLFL-TKSa-------wKNSGDSIDCDDSikHLEVPVNKLSDVIEpc---lSQKENCSP 126 Caenorhabditis ...
Q9U2W2        85 -------TAFPISEYHILISSRVMLTAEHkwiMN----GKPFDKNNCSGg-rHLDVPRDVLDNILF--------WYGKKP 144 Caenorhabditis ...
O76649       145 FQDLVRRVIVINGC---------PDVNSAKVLILELKKPle-lnPSIWPVCISNDPQL-FDRSSDFSVSGI------DAK 207 Caenorhabditis ...
Q21628       149 RTRNVTSAYVFNICana----hsKYKSHYAPMLVEIEGE-----PNEEYACLADTSTI-YKEGDKVHMYGIeyennaRSE 218 Caenorhabditis ...
O45371       136 PPSIPKKAWLHGICknn---ikkLFSSIHTPMLVEVETP-----IPGSSVCVPEKKTQiLEEPSFVYMFIP-------SN 200 Caenorhabditis ...
O62223       135 HSIRPVRAYLLNICtke---ienNFHRIYCPMLVEVENP-----IDSSIPCLVDNSIS-IQKDDAVDVCPLn-----PKS 200 Caenorhabditis ...
CAP22195     145 FRNTIAKVTVINGC---------KQLLASNPMILELVAPl---eNSTVPVCISNSARN-WERVSGFSVYGL------NIT 205
XP_002640478 138 --LPLTRATIFDVCdptnkdfkyGTDISRSLMLAETNGT------FNDYFCLASEVTS-VHKDELLDSYGLaw---nKGT 205
O62231       135 TRCKITAAYILDGCas------sYPMLTAGPLIATIDYSs---qSNISVPCLAQEENL-MNVSEIGDLYFI------DDS 198 Caenorhabditis ...
Q9XWZ8       127 KVMNFARAYILNFCkst----lvQKRVYSFPMILELDENl---eGNSSYPCLADESIK-LAKGDAIDAYGC------TNN 192 Caenorhabditis ...
Q9U2W2       145 KKADISKARMFFACd--------NQDLKAYPVLIELNKTskrpwAFNGVPCLADETTS-SKLGDVVHSYGY-------TG 208 Caenorhabditis ...
O76649       208 GVLNSGLFKPVNCSVegp-fsCAEAVDNKQRMCAYDSGGSAIsnvSGQNTVLGVYVTGNMNCNANpqnltDFKFINIAN- 285 Caenorhabditis ...
Q21628       219 SEWKHRNDPIEDFYSew---iRTLKQGSDRPLAKGDRGGPLV---TDDGVLIGFGSTFALADNAE-----NHYFFDIKY- 286 Caenorhabditis ...
O45371       201 GSVVEKLVNITNS--------NWLEITTQLLGGIKEYCGSLIkkiHGKWTMIGLGTPKNVWKK-------HSFFFNLKR- 264 Caenorhabditis ...
O62223       201 RKRFTSPLNLEIV--------NIASLQTSGYSSEKKTGNPLTkwkNEKLIIIGNWATGDTTDSSR-----SNIFFNMKW- 266 Caenorhabditis ...
CAP22195     206 GRLVSGRFRPIECSAsapfscAEASNKSSQGLCTGDYGGSAItkiNHRHVMLGFYASGNYECQGNtetmdPFKFVNLGH- 284
XP_002640478 206 YELYHRKLKFVGYGQ------APHSMFTEGYISKDEFASALVkekDGKNMLLGIGSANNQKSVRF-----DGHFFKIVD- 273
O62231       199 YKLKHSKTTINHTYS------LFYKTSIPTVFKSRHDYGILTnvvDNKMTVMAFAASDD-----------QNTFYTMSF- 260 Caenorhabditis ...
Q9XWZ8       193 SEWKHRKVNVGAGVS------PDILYGTVPNTEKGFDLGPLTkndSGRVWMVGFDLAATIGSRK------YPWYYKMSSa 260 Caenorhabditis ...
Q9U2W2       209 ESMQHRKLSITAV--------KDERICTDTYKTE-KAGGPLIlnvSGKATVIGLKAPASREN--------CELFYDLSK- 270 Caenorhabditis ...
O76649       286 HRESICKLTGIC 297 Caenorhabditis elegans
Q21628       287 LSSEICYLTNIC 298 Caenorhabditis elegans
O45371       265 FSGSFCHFAGIC 276 Caenorhabditis elegans
O62223       267 LVNEICDLIGVC 278 Caenorhabditis elegans
CAP22195     285 YRKEICETTGVC 296
XP_002640478 274 FKDTICSLAGIC 285
O62231       261 LYKSLCEPTGIC 272 Caenorhabditis elegans
Q9XWZ8       261 MYPALCELAGIC 272 Caenorhabditis elegans
Q9U2W2       271 LQKEICDYSGVC 282 Caenorhabditis elegans
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