1VMO


Conserved Protein Domain Family
VMO-I
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cd00220: VMO-I 
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Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the outer layer; VMO-I has three distinct internal repeats; all three repeats are used to define the domain here; VMO-I has recently been shown to synthesize N-acetylchito-oligosaccharides from N-acetylglucosamine; may be a carbohydrate-binding protein; member of the beta-prism-fold family
Links
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Statistics
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PSSM-Id: 238135
Aligned: 22 rows
Threshold Bit Score: 160.633
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:putative carbohydrate binding site [chemical binding site]
Evidence:
  • Citation:PMID 8848836
  • Citation:PMID 8131734
  • Comment:plays a role in either hydrolysis or sugar recognition
  • Comment:asp and glu are frequently involved in hydrogen bonding between protein and sugar
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #                      #       ##                                     
1VMO_A         7 SVITVPNGGHWGKWgiRQFCH-SGYANGFALKVEpsq-fgrDDTALNGIRLRCld-----------gSVIESLVGKWGTW 73  chicken
4567054       31 SELTVPNGGGWGSWgqREMCPaGTYAAGFSLRVEdpv-greDDTALNGIRLHCieskass-dsyhsySTGQSDVFSWGRW 108 common carp
NP_001023713   9 FVHFVSADNETVPFvgWKVCPnGEFVKGMMIKYQkg----sTTTALDAVALYCaplysc---kedkhNWIMSGEATWGQW 81  nematode
AAX54597      20 STIRSNNGGPWGDWgsESHCPpNSFATGFAIKVErpv-gdsDDTSINGIKLFCtsgn------dgseTEVTSNQQQWGSW 92  signal crayfish
YP_275499    203 PTDEYDNAGSWGTWgpSARCPsGLYINAFDVKGEkwq-gddDDTAVNAIVMYC--------------HDDVGLRSKEGGW 267 Pseudomonas syr...
CAE68538      22 TLNELKGKNEFGEWksWKKCPtFMYAYAVRYEMDq-----eQKGRVKSIAFLCkplswk---thtlpNELARGDPIRGNW 93  Caenorhabditis ...
NP_493793      8 LALLSTAGAEYVHYp-SNGCTrHNVMNGFQLKFEgpqgifkNDHGVVSISFFCnppdgvs-nnaisnKLVIKPELPFGHW 85  Caenorhabditis ...
1255816       11 TVFFADVYGAIQTWekEFACPeGLVINGYQVKSQtkqgwftYDYGVTDMVFFCntpdgknqntdkniTRGNFYPYDNDIW 90  Caenorhabditis ...
NP_500601    301 TVFYTTAHGNLPTRedYIACPkGSVINGFQLKLEtkrgvlsLDHGVTELIFFCnppdgn--tlsidnKIVIYNDSPYGYW 378 nematode
XP_001514636 138 STIEVSNGGPWGSWtwVDMCPeGSYAIGYSLKVEetf-sanDETSLNGIRLFCtnrt-------ssaFTIESNIGEFGYW 209 platypus

Feature 1                              #         ##                                              
1VMO_A        74 T---SFLVCP-TGYLVSFSLRSEksq---gggDDTAANNIQFRCsdea-------------------------------- 114 chicken
4567054      109 T---DIKWCP-SGFLTAFQLRVErsq---gdgDDTAANNILFRCsq---------------------------------- 147 common carp
NP_001023713  82 Ni--QIQWCPsGTTAVGYSIRRSnnhs--ciaQPETLINFQIKCenpyard----------------------------- 128 nematode
AAX54597      93 T---DRRQCP-HGRLTSMRLRVEgrq---gsgDDTAANNLDMRCqng--------------------------------- 132 signal crayfish
YP_275499    268 GtfsGYSKCPaDQAIVGFQLKMEprq---edgDDTAVDSVRFVCegg--------------------------------- 311 Pseudomonas syr...
CAE68538      94 K---GITFCTeGHFLTGLSFRSDpeksgnnseAIDTIDTLKISCgisndq------------------------------ 140 Caenorhabditis ...
NP_493793     86 R---EIQWCPnGTVIIGIQTKSDrg-----riDKAGITNFAAKCgrpevrhhvfkicsktrstktrstktrstfsgsgtv 157 Caenorhabditis ...
1255816       91 R---KIQWCPtGTVVIGMANKLDfg-----kfDNAGITDICSYCgrpeddr----------------------------- 133 Caenorhabditis ...
NP_500601    379 R---SIQWCPkGSVIIGITEKIDse-----kfDNAGITNFGARCgrp--------------------------------- 417 nematode
XP_001514636 210 A---RISWCP-TGFLSSFQLKVEspq---gilDDTAVNNIRFRCstgv-------------------------------- 250 platypus

Feature 1                                                     #           ##            
1VMO_A       115 ----------vlvgDGLSWGRFGPWS---KRCK----ICGLQTKVEspq-----glrDDTALNNVRFFCCK 163 chicken
4567054      148 ------------gtLQGDGTNWGDWGtwsLTCEgk-gICGLKTRIEvpq-----grdDDTSLNDVIMYCCD 200 common carp
NP_001023713 129 --------ikkgvwLEGKTENCGVWDi-kKYCVnktaLCGINTAVKpyk-----rkdIPTGVVDVNIKCCN 185 nematode
AAX54597     133 ------------qeLGGGGNNWGDWSp-wETCQlgqaICGLQTRVEgtq------agDDTALNDVIFLCCR 184 signal crayfish
YP_275499    312 -----------qsiAAAYDTSYGVWKk-tYRCPagmaAIGFETRVEdyqgddddkyhDDTALNGMRMKCGS 370 Pseudomonas syringae pv....
CAE68538     141 --------knrtdsTEDDYLGLDHWNk-gNFCLaghaICGIRLRRDev-------saKETVINIVKVLCCR 195 Caenorhabditis briggsae
NP_493793    158 ptavfstrayatrvAKQNLDTFGGWDk-eINCP----VGEAMHRFRani------srGRGLFKLTHFSCNK 217 Caenorhabditis elegans
1255816      134 --------tkktysAWEDLNTHGSWAr-dQMCD----VGSALANNQsp-------dnFIVIDNNSPYGYWR 184 Caenorhabditis elegans
NP_500601    418 -----------edrTEQPSFLFGMVEy-nITFIi--sACSECSNLEc---------sNSNTLNAAQLKYEK 465 nematode
XP_001514636 251 ----------vlenPGGPYGEYASWS---DACPrg-gICGLQTKQEpyrg----llwDDTALNDVRFFCCE 303 platypus

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