Conserved Protein Domain Family
OYE_like_2_FMN

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cd04733: OYE_like_2_FMN 
Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.
Statistics
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PSSM-Id: 240084
Aligned: 39 rows
Threshold Bit Score: 428.927
Created: 17-Jul-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:
  • Citation:PMID 7881908
  • Comment:Based on similarty to other members of the family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          # #                                       #                
YP_111577  25 LAQPLTLPn-gTVLKNRLAKSALSEalcg-------hdgrVTPQLIALYRRWSGSGAGLLVTGNVMIDGKAlgep----- 91  Burkholderia pseud...
EAA71696   16 LAQPLKFEfsgETAKNRLMKAAMTErlstwdpkilekrgvPTPELVNVYRRWGEGDYGVILTGNVMIEYDHleaagnpii 95  Gibberella zeae PH-1
XP_361349  16 LGTPLKYPvsgRSAPNRFLNAAMSEglatfdeadpskrgiPTEQLVQLYRRWGQGEWGQIQTGNVMIDPEHleapgnmvv 95  Magnaporthe grisea...
NP_503516  17 LGEHLKFRn-gRETNNRFLKAALTEiqssyypdepkrhglPTDAILNIYDKWGNGSFGMILTSNVLVDPTNleaagn-ai 94  nematode
EAL90551   15 LGKPLQFKiskRTAPNRFYKAAMTErmsswsptdlkargvPSRELINLYKRWGEGGYGLISTGNIMIAYDQleapgnpii 94  Aspergillus fumiga...
AAS66029   13 LGQPLEFHfarRSAPNRFLKAGMSErmcswteenpsargiPSRELIETYRTWGRGNIGAIVTGNVMIDPNHieaegnpti 92  Aspergillus parasi...
BAE66156   15 LGRRLLFSfsgKWAQNRLLKSSTAEcmasfsasdsgsrgiPSAELANLYRRWGEGDIGVIITGNIMIDPQHlvsagdpii 94  Aspergillus oryzae
EAK82750   13 IARPLVFKg-gKVVPNRLAKAPLEEtlart------gggpPNHAHFELYRAWARGGWGLIITGNIAIDPLHrgtpwdvil 85  Ustilago maydis 521
NP_505014  16 LGEPLNFRn-gKKANNRILKSPLSEkmyrwnehieeklglPTDEIINLYSHWGNGGFGLIITGNLAVDPKFigeagq-gi 93  nematode
EAA73480   16 LLEPLEYVfagQKAPNRFLKAAMSEklaswdandvsargyVTPELLTLYKNWGAGGWGSILTSNVIIDGMNleaagnlti 95  Gibberella zeae PH-1
Feature 1                                             #                                       
YP_111577  92 gnvVIEDDRDLPRLREWAAAAKAh----------GSEIWMQINHPGKQamrglneetvap--------------saigfg 147 Burkholderia pseud...
EAA71696   96 prdAPISGERFEAFKEMATVSKKh----------GSLIIAQVSHPGRQvaediqknpisas-------------dvqleg 152 Gibberella zeae PH-1
XP_361349  96 prdAEPSGERFDMFSKLAAAAKEh----------GSLIVAQVGHPGRQargsvqqhpisas-------------dvqlkq 152 Magnaporthe grisea...
NP_503516  95 ifkEGDCHERRALFTYWAKLMKQd----------GALAVMQISHAGRQtpvfvnptpwsas-------------dvqlvs 151 nematode
EAL90551   95 dleNPFHGERFDAFRELASQAKRh----------GSLIIGQVSHPGRQteerlqpnpvsas-------------dvqldk 151 Aspergillus fumiga...
AAS66029   93 ppnALFSGERFDQFANLAAAARAn----------GSLILAQISHPGRQtpshrqpepisas-------------dvpldt 149 Aspergillus parasi...
BAE66156   95 pidAPFEGLRFERFSKIALEAKCh----------GSLIIAQLCHPGRSfg------------------------------ 134 Aspergillus oryzae
EAK82750   86 pydEKSLAFFKTAMKRYADACTGrdqpgivdqksRPLAVVQLVHAGRQsmrgsgrsitapalapsavpmstmanfgpigk 165 Ustilago maydis 521
NP_505014  94 lsiENTSAESLKIFSRLAQAMKSd----------GALAIAQTNHIGVQaqtaytnsl--------------------geq 143 nematode
EAA73480   96 padEPFEGRRFDGYKELAAVAKKs----------GNLLIAQVSHAGRQveewiqpnpisas-------------dvqlvs 152 Gibberella zeae PH-1
Feature 1                                                     #                               
YP_111577 148 pklspyFAVPRAlt-vDEIDALIRRYGTTAAVAQQAGFTGVQLHGAHGYLINQFLSPQhNQRTDEWGGSAENRRRFVLAV 226 Burkholderia pseud...
EAA71696  153 evmgmhFAKPKPmd-eQDFKNVIEGFAHAAEFLYKAGFNGMQLHGAHGYLLAQFLSPTtNKRTDKYGGSIENRARIIFEI 231 Gibberella zeae PH-1
XP_361349 153 emfgskFGVPRPat-kEDIKAVIEGFAHTAEYLEKAGFDGIELHAAHGYLLAQFLSETtNQRTDEYGGSLENRMRLILEV 231 Magnaporthe grisea...
NP_503516 152 aarfttYGKPKPlsteQVETEVVDRFVYAAKFAYECGFDGIQLHGAHGYLLSQFTSPTtNKRVDKYGGSLENRQRIVIEI 231 nematode
EAL90551  152 eimgmqFAKPHAas-kDEITDFIRRWTHAAVYLHKAGYDGIQLHGAHGYLLAQFLSQTtNRRTDEYGGSLENRARLIVEI 230 Aspergillus fumiga...
AAS66029  150 enmgntFAVPRAat-eNEIKNIITGFAHAAEFLDRAGYDGVELHAAHGYLLNQFLSRAtNLRTDKYGGTLTNRMRLILEI 228 Aspergillus parasi...
BAE66156  135 ----adFGKPREak-rEDINYIVEGFAHAAAYAEKAGFDGIQLQAAHGHLLSQFLSPRtNKRQDNYGGSIKNRMKLISEI 209 Aspergillus oryzae
EAK82750  166 vldhllWGSVAAmt-tEQVHQLRDRFVQAALICADAGFDGVELHASHGYQLAAFLSPRtNLRTDQYGGSAENRARLVLEI 244 Ustilago maydis 521
NP_505014 144 hilvkeVANPMNfsvqQIKENVLKRFANAASVLYESGFDGMEIHSAHGMIFNQFLAPK-NTRNDEYGGSIENRARLLTET 222 nematode
EAA73480  153 sspgktYGVPRPat-kEDIATVINGFAHAAEFLEKAGFDGIELHGAHGYLLAQFLSPRtNNRTDEYGGSRENRMRLVLEV 231 Gibberella zeae PH-1
Feature 1                           #                                                         
YP_111577 227 YAEVRRRVGp--dFPIGIKLNSADFQRGgfteeESLDVIRALAEa-gIDLIEISGGTYEtpvmql--------------- 288 Burkholderia pseud...
EAA71696  232 ADAIRARVPdk-sFGLSIKVNSVEFQEGgfstdDCKVLCHQLENh-gFDFVELSGGTYQslafa---------------- 293 Gibberella zeae PH-1
XP_361349 232 TAEVRRRTSk--nFILGIKINSVEFQEKgfkpeEAVQLCEALEAa-gMDFVETSGGTYEsfgfa---------------- 292 Magnaporthe grisea...
NP_503516 232 YDAIRAEIPastgFLIGIKTNSVEFQSEgltleDAKTMCQVYESk-gFDFVELSGGTYEqlnwt---------------- 294 nematode
EAL90551  231 AQSIRKELPastgFILGIKINSVEFQAGgftadEARELCQILEEn-eFDFVELSGGTYEfiafs---------------- 293 Aspergillus fumiga...
AAS66029  229 RAAITEKVRp--gFIVGIKINSVEFQPNgivpdEACELCCALEEh-rFDFVELSGGKYKnleedd--------------- 290 Aspergillus parasi...
BAE66156  210 RKAISERVAe--tFTVGIKINTVEFQEStfnleETVQLCIEFEKm-rFDFVELSGGTYEdwtigr--------------- 271 Aspergillus oryzae
EAK82750  245 VDLIRKQVNd--dFIIGVKLNSSDYVQGgltedDALLNVKWLADtdkVDFVEISGGNYEnpsfamsgfdseaekakiekl 322 Ustilago maydis 521
NP_505014 223 YKAVREVVPestgFIVGVKLNSRDFQESgisreDIIKVCELIENs-gFDFVELTGGAMEsvvkev--------------- 286 nematode
EAA73480  232 IAEIKRRVSp--kFIVGIKANAVEYTPGsvdveDAKALAIELEKa-kVDFLELSGGNYEkfafa---------------- 292 Gibberella zeae PH-1
Feature 1                                                                                     
YP_111577 289 -------------------------------gdrkasTIAREAYFLAFAEKVRAdv----kVPLMVTGGFRSLAGMEAPL 333 Burkholderia pseud...
EAA71696  294 --------------------------------hrresSKKREAFFLEFAEKIIPel---kkTKAYVTGGLRTVHAMVEAL 338 Gibberella zeae PH-1
XP_361349 293 --------------------------------hrkesSRKRENYFIEFAEVIRKav---khMVVYTTGGFKTVGAMVDAL 337 Magnaporthe grisea...
NP_503516 295 --------------------------------weresTKKREAFFVEFAEQIRPvf---nkTVVYLTGGFRTVSAMINAI 339 nematode
EAL90551  294 --------------------------------hkrdsTKQRESFFLEFASLITPal---skTKSYVTGGLRTASGMVGAL 338 Aspergillus fumiga...
AAS66029  291 -------------------------------nakhiiSKRHEAFFLDVAQKVVSsl---tkMKSYLTGGFRSTAGMVDGL 336 Aspergillus parasi...
BAE66156  272 --------------------------------kqvasIPQHEGFFLEYGRIYSEkm---erTKVYVTGGYRSVKGMIRAV 316 Aspergillus oryzae
EAK82750  323 sskttsanqksdwkatgagaatvqgsgvdptskttarTGRREAFFQNFARRCRStlpadsrLKIILTGGLRSRHGIASAI 402 Ustilago maydis 521
NP_505014 287 --------------------------------qkrhsTIAREDFFLDFVQFTSKif---keTVVYITGRWQTANAMVTSV 331 nematode
EAA73480  293 --------------------------------hvkeeNRKRENYFLSQAEEIVKslt--rdMKVFSTGGFKSVKAMVDSL 338 Gibberella zeae PH-1
Feature 1                 ##               
YP_111577 334 rd--gaLDLIGLGRILAIEPDAPARLLRG 360 Burkholderia pseudomallei K96243
EAA71696  339 k----tVHGIGLARPTTNEFDLPAKLIKG 363 Gibberella zeae PH-1
XP_361349 338 q----gVDGIGIGRAAGSEPDLAKDIIAG 362 Magnaporthe grisea 70-15
NP_503516 340 sc--naTQGIGLGRPITAEPDLPKKILKG 366 nematode
EAL90551  339 e----tVDGVGLARPACQEIRLPRDILDG 363 Aspergillus fumigatus Af293
AAS66029  337 q----tVDGIGLARPFCQEPYLCHDILRG 361 Aspergillus parasiticus
BAE66156  317 q----eVDGIGLARPLCQEPHLCSHILSG 341 Aspergillus oryzae
EAK82750  403 hpddgaADMACLGRPAAIFPSLARRLTDT 431 Ustilago maydis 521
NP_505014 332 nm--glTSGVGLGRWSCSEPDFPRKLIAG 358 nematode
EAA73480  339 d----iIDGVGLGRASAQEPRFPELLKKV 363 Gibberella zeae PH-1

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