Conserved Protein Domain Family
7TM_GPCR_Sri

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pfam10327: 7TM_GPCR_Sri 
Serpentine type 7TM GPCR chemoreceptor Sri
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Statistics
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PSSM-Id: 313539
Aligned: 51 rows
Threshold Bit Score: 257.088
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O17360         7 F-CPRECPAHYEPIIHSIGVVSTVFNVFGIYLTLAKSKKNTNYRFCQLYVQITALITEFDISIVNPAYFFFPMIGGMNCG 85  Caenorhabditis ...
XP_002633244   7 VtVDVNTPNILLTFYRIHGVFALVFNILGVVLIMKNPRIVRLYRGFMLNMQILSLLADAQTTLLMQPVYIFPIIGGYTNG 86 
O62308         5 PpCPSSIPTYYLLTLHIIGGISIPINLIGFYLVWFQSPKMQGYKYCLCYLQLVSFIAEIEMIFICPAFYFFPLIGGFNVG 84  Caenorhabditis ...
O62176         5 PpCPSEIPTYYPLTLHIIAGISIPINFIGFYLVWFQSPKMLGYKYCLCYLQFASFLTEMHMSFICPGYYFFPLTGGFNTG 84  Caenorhabditis ...
O45372         5 PpCPSEIPTYYPLTLHIIAGISIPINFIAFYLVWFQSPKMQGYKYCLCYLQAASFITEIHMSFLCPGYYFFPMIGGYNTG 84  Caenorhabditis ...
O18113         3 ApCPEIIPFYYTTTLHVIATISVPINLIGLYMVWFQSPGMQGYKYCLCYMQTVSFLTEIHMSWICPGYYFFPMVGGYNTG 82  Caenorhabditis ...
O18110         3 ApCPPTIPAYYTLTLHIIGAISLPVNAIGFYMVWFQSPGMFGYKYCLCYMQTASFVTEIYMSWVCPAFYFFPMVGGYNTG 82  Caenorhabditis ...
O45314         3 ApCPETLPAYYMPTLHVIGAISIPMNVLGFYMVWFQSPGMQGYKYCLCYMQSVSMLTELYMSWICPSYFFFPLAGGYILE 82  Caenorhabditis ...
Q22358         3 ApCPETLPNGYLLTLSIIGGISIPMNLLALYMIWFQSPGMHGYKYCLTYMQVASFIVEINVTWLVPAYHFFPLTGGIAAG 82  Caenorhabditis ...
O45759         3 ApCPATIPDGYLLTLDIIGGGSLSMNFLAMYMIWFQSPGMHGYKYCLTYMQFASFLVEFNLTVLVPAYYFFPLTGGIAVG 82  Caenorhabditis ...
O17360        86 --KMREVqvkFGITSHICITFFTFILCLQVPALLTCFIYRHQVAAKCSpdKTWSLSK----FHLYSILFIYHIFPCLIAF 159 Caenorhabditis ...
XP_002633244  87 --VWWNV---FRMSSHLQMGIFLLLLYLQVASIVCAIVTKYHVVSNIGntTNRP-------LLFWNFVIFYHCCAFLIFG 154
O62308        85 adIIANN-----ISSHHTMTLYVFVFTFELPSTLLCFIFRHNAAGKVD--QKCFSSK----YLKKFSLVLAHFLPFVTAF 153 Caenorhabditis ...
O62176        85 ----GQF-----ISSHLSITIYTFIFSFEVPSTLLCFIYRHTSSQNIS--KKTNPSSksklYLEKASLILTHLFPFSSAF 153 Caenorhabditis ...
O45372        85 ----VEF-----ISSHTSMSIYVFIFAFELPSALLCFVFRHNAAQNIS--RTAPNKK----YFKTFTLFLTHLFPFAAAF 149 Caenorhabditis ...
O18113        83 e-FFGQF-----ISSHLSMSLWVGVFCFELAAGLTCFVYRHNAAAQIN--QTYSSKL----YLDKFLLFLTHLFPFFTGI 150 Caenorhabditis ...
O18110        83 e-FFGQF-----ISPHMSMSIWVGIFCFELSAGLTCFVYRHNAAVQIN--QNQSSKM----HFNKLLLFITHIFPFFTAI 150 Caenorhabditis ...
O45314        83 e-NFRRF-----VSTHASLTIWVFIFCFVLSAALTCFVYRHNAAAQIN--QDYSGKM----YFEKLLLVLTHIFPFFTGF 150 Caenorhabditis ...
Q22358        83 e-IIRKF-----VSNHTGVTIWIFLFCFLLPASLLCLFYRHNAASKIN--QSGSNNL----YLEKLVMILTHIFPFLTAF 150 Caenorhabditis ...
O45759        83 e-VVRKY-----ISNHMGLTIWMFMFCFVLPASLSCFIYRHTAASQI---QNNASKF----HLKKLVMILTHIFPFLTAL 149 Caenorhabditis ...
O17360       160 SLYHSGLSKDEKNYSMHMNYPGCIHSLdDF-TFDFYDYQvnPTFIAFGILISVYYVMAGVIGFGLAWRTGQVLNRYRYIM 238 Caenorhabditis ...
XP_002633244 155 IFCMSYLTKEQAVDLVKIKFPNAMNIF-TVeNVEIYDMEvnKWMIMTTMIIAM-LTSSILISLYFSIRLLKTLRSKRLVI 232
O62308       154 CFWNSRLTAKERMDLVMNNWPQCAHWL-KFpAFEVYDYHlnPWLAVVGIGAFFVLFMVFSYCIFLGVQTLLILQQHRKSM 232 Caenorhabditis ...
O62176       154 CMWNSKITSRQKQNFVKNNWPQCSSWL-ELeAFEVYNYEsnQWLAALGAVVFGTILLSYSYAMTLGIHTMTILRKVRKSM 232 Caenorhabditis ...
O45372       150 CMWNSNLTNQQKQDFVEENWPQCTQWL-KFfAFEVYDYMlnPWLAVVGIGAVALVFMVYGYGLGLGTHTMMILQRFRKSM 228 Caenorhabditis ...
O18113       151 SMWYSKLTYQQKFEYVRQNFPQCLSWL-AFdGFEVYDYHlnKMMAVTGVGAFAYVFIIAWYCFYLGVHTMIILQRLRQHM 229 Caenorhabditis ...
O18110       151 SMWNSSLTYQQKYDFVKKNYPQCLFWM-AFdGFEAYDPHqnPWMFVTGIGALIWVFFIVWYCVYLGVHTMIILQRLRQHM 229 Caenorhabditis ...
O45314       151 GTWMSQLTYEQKYDYVRQNYPQCLSWM-AYdGFEAYNWQvnTWIPVAGLGGIGWVFVVASYCLYLGVHTMMILQRLRAHM 229 Caenorhabditis ...
Q22358       151 GTWNCQMTFAQKYEYLSQNYPECLFWL-ASdRFEAYDYKmnPWIVSTAAAAITFLVITASYGGYHGIHTMIILQRLRAHM 229 Caenorhabditis ...
O45759       150 GTWNCQMTFDQKYEYVRKNYPQCLFWL-EFdRFEAYDYQvnPWIVRTACAAIGFLMISTCYGIWLGVHTMVILQRLRGHM 228 Caenorhabditis ...
O17360       239 SARTYQLHKSSLITLTTQVSGPTLVLgIPVFVVYVIVASQMTQLHDLAATAPFFISAHSAVTTSCLIMTTANYKNLF 315 Caenorhabditis ele...
XP_002633244 233 SARSFRGHQIAVTSLMAQATIPFIVIiIPIGTIVYFFVHIVPNSQGISNIMMAIYSFHSSLSTAVMIISTPQYRKMI 309
O62308       233 SRQTYQAHKNALFRLVMQIVLPGVFIvVPLCICMFVVVQGDVHLQEFATDTMFFVSSHSMCSCIIMIISNPKYRSVL 309 Caenorhabditis ele...
O62176       233 SRQTYQMHKNALFSLVMQIVIPGVFIiVPLSICMFVIITEEVSLQELATDTMFLVGSHSMCSSAVMILSNPKYRCVL 309 Caenorhabditis ele...
O45372       229 SRQTYQQHKTALFSLVMQLLIPGVLIiVPLGVCMFVVVTGEVGLQEVATNTMFLVGSHSMCSSAVMISSNPRHRKYL 305 Caenorhabditis ele...
O18113       230 SSQTFQMHRAALISLAMQMVIPGVFIiVPLDICMTVVITETVALQEFATDTMFMVGSHSMCQCSVMLLSNSTYRRVL 306 Caenorhabditis ele...
O18110       230 SSQTYNMHRAALFSLSMQMALPGGLIvIPKNIMLFIVIGEATHLQELATNMTFLMASHSMCQCSTMILSNSVYRRIF 306 Caenorhabditis ele...
O45314       230 SPQTYQMHRTALISLTMQMVIPGMLLtTPLYMILVVIMTNSLAFEELASTFSFLMSSHSMCQCFVMVMSNGVYRRVL 306 Caenorhabditis ele...
Q22358       230 SVQTYQMHITALISLALQMLTPSVFA-VPVYVWVTVVLTNAIDLQGIVSWSPCLMSTHSILMSSVMIVTNATYRRVL 305 Caenorhabditis ele...
O45759       229 SVQTYQMHLTALISLGLQMATPTVFI-LPVYMFVAVIVTDAVDMQRIVSWAPCLMSTHSMLLVTVMIMSNASYRKVL 304 Caenorhabditis ele...
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