7KZP


Conserved Protein Domain Family
FANCF

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pfam11107: FANCF 
Fanconi anemia group F protein (FANCF)
FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway.
Statistics
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PSSM-Id: 463222
Aligned: 24 rows
Threshold Bit Score: 209.51
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7KZP_F        26 MESLLQHLDRFSELLAV----SSTTYVSTWDPATVRRALQWARYLRHIHRRFG--------------------RHGPIRT 81 
XP_015689495  10 MEEVLALVRSFVDVLVLaggsTSSGSAAAWRSGDVKKAFQWALFFEEVFKNLRdigryddsardldaalveltSSPNFPK 89 
XP_005809971  10 MEAVLKNVGCTVELLAVa---AHSGVVNEWDEQTVTRAFHWARYCEHIYSRFH--------------------GNPVIRG 66 
XP_004070011   1 MEAVLKNVASAVELLAVa---AYSDAMSQWDEKTLSRAFHWARYCEHVYTRFH--------------------TNSAGRR 57 
XP_005450884   1 MEAMLKNLASTVEMLAVa---AQSDAVKHWDKQTLSRAFHWARYCEHVFSRFH--------------------NNAAIRR 57 
3_pfamImport   1 MEAVLKNVAGTAELLAVa---SLSGEVERWEEPTVSRAFQWARYCEHLCRRFH--------------------DNPAIRR 57 
XP_007228290   1 MEAVLKNLGSTLEVLAV----SETEFVREWDARTVDRAFQWAKYCEHVYNRFH--------------------ANPSIRP 56 
NP_001038699   1 MEAVLRHLNNILELLAV----SRTDRVREWDRPTTQRAFKWAEYCEQLHSRYQ--------------------SNPTVRS 56 
XP_012823448   5 MHTLLENLDRYIEVLTL----SQSVHVKDWDISCVRRGFEWGTYFQQVYHRFH--------------------TNECLRN 60 
XP_006011742   1 MEALLENLTRFCEVLAV----ARSDYVSEWDSRTLHRAFQWADYFQHICGRFG--------------------ANAPVRE 56 
7KZP_F        82 ALERRLHNQWRQEGGFGRGPvpgLANFQALGHCDVLLSLRLLENRALGDAARYHLVQQLF-----PGPGVRDAD------ 150
XP_015689495  90 GIE--------------------DLRSKTLSRARELVVKHFLKTTSVDN--LGAVLEAVVemdidGICPSGERDvcqeyv 147
XP_005809971  67 VLEKQLQLTNHRLKEAFPEYn--AVSFLDLGRCQDLLLLWLLNNSALPISIMKMLFETKA------SADSTSSD------ 132
XP_004070011  58 VVEKQLQHTNARLRDAFADYr--EVSFMDLPRCEHLLLLALLSNPHLPISTMKILFGKKD-------VASRYYD------ 122
XP_005450884  58 IMEKQLQLTNQTLRDTIPGYt--EVSFSDLPRCQHLLLVRLLNNPELPSSLMKMLFDTAR------PVKTMHGE------ 123
3_pfamImport  58 VIEKQLRVTNHGLRAAFAGYg--DVSFSDLYRCQHLLLVGLLKNPQLPISVMKILFDA------------EQSE------ 117
XP_007228290  57 VLEDCLRLTNERLSEGLSGHr--ALSLADLAQCRHRLFIGLLRNPLAPHSVFKSLFDNCR-----LFEDDGDTKp----- 124
NP_001038699  57 SLESGLTDTNRRLKETFPSYs--PVEFSELAQCQHKLIVYLLRNPSSPHFIIEMLFPDQNs------------------p 116
XP_012823448  61 ALEDHLRSKNETLSACIKNYq--YITFNDLRYGKEIFCMSLLQNKALSKDIFQYIVRQLK----------NLSS------ 122
XP_006011742  57 ALERRLRLANESLSRNFEGYr--FLSFEALRRCGETLRLSLLGNPAVSQSLYPRVLAGLE-------------------- 114
7KZP_F       151 EETLQESLARLARRRSAVHMLrf-----ngYRENpnlqEDSLMKTQAELLLERLQEVGKa--EAERPARFLSSLWERLP- 222
XP_015689495 148 RSILDMNLSRLMLKRNACDVG---------HPPSseicEESLL-GNSQILLKELQKKLDtslCISLAERGLSTLLKSMKn 217
XP_005809971 133 YEDVRGLCNQIIQCKSACTVL---------RPLLgvpsVGADAEVQGEMLMERLGSALSqssDPRRVEDFLSSVLQEFEv 203
XP_004070011 123 YKEVTGLCSHLIQCKSACKVL---------CPFSglsaVDADAEVQGEMLMKRLDALLSqgsDPQQAEHFLHSVLLLSEe 193
XP_005450884 124 YEDVTGLCSHIVQCKSVYKVL---------SPLAdmsaLGADAEVQGEMLMERLEALLNqgsETCRAEHFLGSVLQGCEg 194
3_pfamImport 118 YQEVTGYCSRIIQCKSACKVL---------SPLAdssaVGADAEVQAEMLMERLGALLSrggEAR---HILDSVPQGFEg 185
XP_007228290 125 GRETHLDLSGLIMCRSACKLLgs-----fqLNSQetsdISFSTQVQGLMLLQRLHAIQChpgNDSYLRKLMDTFLQDVGq 199
NP_001038699 117 SQELLAAQNSLVTRKSAFSLLcc-----tvNRTSsyygLQTEPEVRGKLLGKLLNSILArpgNEEHAKCLLDSVRCNSAg 191
XP_012823448 123 GETSICSMSNIMCQKAALQLLlf-----ssSIASknplENPCVVTQAEILKNHLENRIRl-lKGDHQFAVVADVLSGIP- 195
XP_006011742 115 DRASLEDLRRAVGQKAAARVLfeagaasrsRTPDelpgADPVARTDAALLIQYLNDRQRrldSSGDRERLVEVALGKLAg 194
7KZP_F       223 Q-NNFLKVIAVALLQpPlsrrpqeelePGIHKSPG-----EGSQVLVHWL----LGNSEVFAAFCRaLPAGLLTLVTSRH 292
XP_015689495 218 N------------------------------------------------------SFDDAGSTSC--------TPATAWK 235
XP_005809971 204 AaEHLCPVIAAALLT-T----------DSAVQTA-------SQDFLLDWL----QSRRGVLQHVCTaLPSKVLADLAERH 261
XP_004070011 194 AaHHSCLVITAALLTaS----------DSGTQTS-------SQSFLLNWL----QKEHGMLQHMGStLPSAVLKDLARAH 252
XP_005450884 195 AlQQFCVVIAAALLTsK----------NCAAQTA-------AHDFLLDWL----QKNHSLLQHMCSlLSPTLLRDLAKEH 253
3_pfamImport 186 AaGHFCVVIAAALLMkK----------NS------------SQDFLLDWL----QKEQSVLEQMCSsLPSALIIELTKKQ 239
XP_007228290 200 DlDHLFEVIAACLLIeN----------ETSEEHTa------AQDFLLDWLqdhhQNHHSLLQTMCQsLPLQMCTKLSQKQ 263
NP_001038699 192 KvDGFYDVIAGALLCsS----------DE------------SQRFIITWL----KESDGGLNTFCSvISPEVCAVISRQS 245
XP_012823448 196 Q-PSVYKILAVLLLSsE----------TCDSQGQv-----SLSHLFLKWL----LENDSAWTDFCSkINCHLLSRLSSKY 255
XP_006011742 195 S--QLWPVLAAVL---------------------TddaggVAVDLVLSWL----LGNGGQLQAFCTcVHCILLTEIASRH 247
7KZP_F       293 PALSPVYLGLLTDW------------------GQRLHYdlqkgI-W--------VGT--ESQDV--------------PW 329
XP_015689495 236 TQIIDKFI-LWKQWrakclsyllnertiriisGTKLIFnapkeQ-WiglfgplkVSAdsYQSGLievmeicllglaarQW 313
XP_005809971 262 QKFRDAFCKLLKKW------------------ASEMEYrvtegE-W--------VHAa-TNSAV--------------SF 299
XP_004070011 253 GKFRDAYFSALKKW------------------ASEMEYslndgE-W--------LPEg-TAPSL--------------SF 290
XP_005450884 254 QKFRDAFCNVLKKW------------------ASEMEYslndsE-W--------VLTs-TGPTV--------------SF 291
3_pfamImport 240 PKFRDAFCDLLKKW------------------ASDMEYslsegE-W--------IQTr-RNPTV--------------SF 277
XP_007228290 264 KKIRLMYWEVLKQW------------------ASSMEYdvsggV-W--------VQQcdTFP----------------SF 300
NP_001038699 246 PEFRKLYWGALKQW------------------ASCLEYdviesV-W--------VTS---EGAG--------------SF 281
XP_012823448 256 VIVSKAYMDFLIKV------------------GESMELdv-hgK-W--------VSS---NAEL--------------PF 290
XP_006011742 248 PRFRAAYLQVLTEW------------------GESMEYmpsggRgW--------MSS---LPGL--------------DW 284
7KZP_F       330 EELHNRFQSLCQAPPPLKDKVLTALETCKA--QDGDFEVPGLSIWTDLLLAL 379
XP_015689495 314 NSLIESFMSHTFSFFPISKQYADLRQLLQGtaQD---------VCEDKLLGF 356
XP_005809971 300 QKMTEHYLTLFEACPSLRTEVEDELNAQRI--ADGDFDVRGLSVWGDILLAL 349
XP_004070011 291 QEMVEHFSDLFDACPSLRRNAEDELLALKI--LDGDFDARGLSVWGDILSEL 340
XP_005450884 292 KKLTELFLALFEASPSLKGGVEKELNALKI--SDGDFDVTGLSVWGDLLSAL 341
3_pfamImport 278 DRLTEHFLGLFETCPSVRVDVEEELNALKM--SDGDFDVRGLSVWGDLLSVF 327
XP_007228290 301 KTLVNHLKSIWRSGSPLKEETEKELVVLKQ--VDGDFEVQGLSVWTDLLLQL 350
NP_001038699 282 DVLADRLRDLINSGESLKEETETALKALTL--QDGDFSVKGVSVWTDLTLQL 331
XP_012823448 291 NTFRNHFESLMNTSEDLRSATEAKLKALKS--QDGDYDLPGISIWTDILLEV 340
XP_006011742 285 GKLLKHFSSLIKGPKAVQEATESTLQTLKA--QDGDFNEWGISVWTDLLLAL 334
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