2L03


Conserved Protein Domain Family
TFP_LU_ECD_LYNX1
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cd23585: TFP_LU_ECD_LYNX1 
extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein
LYNX1 (also called testicular tissue protein Li 112) is an endogenous prototoxin that acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). It prevents plasticity in the primary visual cortex late in life. LYNX1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467115
Aligned: 8 rows
Threshold Bit Score: 96.9924
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2L03_A         1 MLDCHVCAYNGdNCFNPMRCPAMVAYCMTTRTYytp--------------------------------------trMKVS 42  human
P0DP58        20 ALDCHVCAYNGdNCFNPMRCPAMVAYCMTTRTYytp--------------------------------------trMKVS 61  human
NP_035968     20 ALECHVCAYNGdNCFKPMRCPAMATYCMTTRTYftp--------------------------------------yrMKVR 61  house mouse
NP_001012437  20 ALDCHVCAYNGdNCFNPMRCPAMVAYCMTTRTYytp--------------------------------------trMKVS 61  chimpanzee
NP_803252     20 ALDCHVCAYNGdNCFNPMRCPAMVAYCMTTRTYytp--------------------------------------trMKVS 61  human
NP_001266926  20 ALDCHVCAYNGdNCFNPMRCPAMVAYCMTTRTYytp--------------------------------------trMKVS 61  Bolivian squirr...
NP_001028116  22 ALDCHVCAYNGdNCFNPMRCPAMVAYCMTTRTYytp--------------------------------------trMKVS 63  Rhesus monkey
XP_020144631  20 ALDCHVCAYNGdNCFNPMRCPAMVAYCMTTRTSsaqamwchqckgfggcshvarcrggsthciafatrdlisfkdlPLVT 99  gray mouse lemur

2L03_A        43 KSCVPRCFETvYDGYSKHASTTSCCQYDLCNG 74  human
P0DP58        62 KSCVPRCFETvYDGYSKHASTTSCCQYDLCNG 93  human
NP_035968     62 KSCVPSCFETvYDGYSKHASATSCCQYYLCNG 93  house mouse
NP_001012437  62 KSCVPRCFETvYDGYSKHASTTSCCQYDLCNG 93  chimpanzee
NP_803252     62 KSCVPRCFETvYDGYSKHASTTSCCQYDLCNG 93  human
NP_001266926  62 KSCVPSCFETvYDGYSKHASTTSCCQYDLCNG 93  Bolivian squirrel monkey
NP_001028116  64 KSCVPSCFETvYDGYSKHASTTSCCQYDLCNS 95  Rhesus monkey
XP_020144631 100 KMCHRGCPDI-QSLGLGPHVSMICCQANLCNH 130 gray mouse lemur
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