Conserved Protein Domain Family
PGAP1
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pfam07819: PGAP1 
PGAP1-like protein
The sequences found in this family are similar to PGAP1. This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body. This entry also includes Tgl2, a mitochondria protein that serves as a triacylglycerol lipase in budding yeasts.
Links
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Statistics
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PSSM-Id: 369540
Aligned: 19 rows
Threshold Bit Score: 157.911
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9LTZ8    109 KLSGVPVLFIPGNAGSYKQVRSVAAESDRAFQGgpfertfyqeasllrgggadtesVDYD-------------------- 168  thale cress
Q6C2Z2     73 EVGGRPVLFVPGNGGSMRQIRSIAGEAAVQYWHdprragadadtwangstarpksaLQKLntfafgdtesdtegvrglgd 152  Yarrowia lipolyti...
Q9KQA3     10 EGSGETVVLIHGLFGSLDNLGLLARDLKNDHQV-----------------------LSLD-------------------- 46   Vibrio cholerae
Q66J01     77 TLTGVPVLFLPGNAGSYKQARSFASVA-----------------------------LRKA-------------------- 107  African clawed frog
Q75T13     82 PLTGIPVLFLPGNAGSYKQVRSIGSIA-----------------------------LRKA-------------------- 112  human
Q7PSQ5     76 LFTGAPVLFVPGSGGSYKQVRSLASVA-----------------------------LRKG-------------------- 106  Anopheles gambiae...
Q9W495     79 RMTGAPVIFVPGNAGSYKQVRSLASVA-----------------------------LRKA-------------------- 109  fruit fly
CAP39834   91 DINQIPVLFIPGSQGSAKQVRSIASVM-----------------------------QNKT-------------------- 121 
Q67TV0     79 NLNGVPVLFIPGNGGSYKQVRSLAAESFRAYQNgpleptfyre---astafsvnelEGFS-------------------- 135  Japanese rice
Q9UT41    151 EPSGIPILFIPGNAGSYKQVRAFAAQAAHVYANay-------------------aeDADG-------------------- 191  Schizosaccharomyc...

Q9LTZ8    169 ------------------------LPSQYSNR--LDWFAVDLEGEHSAMDGRILEEHTEYVVYAIHRILDQYkeshdtre 222  thale cress
Q6C2Z2    153 avtardmsgddrrdaverplsngkLPSQWPDDlpLDFFTVNFQEDLTAFDGTTVIDQAEYLNQAIAYILSLY-------- 224  Yarrowia lipolyti...
Q9KQA3     47 ------------------------LRNHG-----LSFHSDEHNYALMAQDVNQLLEHLNL-------------------- 77   Vibrio cholerae
Q66J01    108 ------------------------ENIGNRYH--FNIFTVNFNEELVALYGGSLRRQTRFVHECIKTILSLY-------- 153  African clawed frog
Q75T13    113 ------------------------EDIDFKYH--FDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY-------- 158  human
Q7PSQ5    107 ------------------------LDNNWQAH--LDYFSVDLNEELSGVYGGYLQDQTDFLDLCIQEITRLY-------- 152  Anopheles gambiae...
Q9W495    110 ------------------------MSNDAGIH--LDYYTIDYDEELSALYGGYLHRQQSYLKLCIRTILSIY-------- 155  fruit fly
CAP39834  122 ------------------------EMRQSVFS--FRFFAVDFDEEKTFMNGHTVNRQLDYVMKAIRKIQSLM-------- 167 
Q67TV0    136 ------------------------IPSRYGRM--LDWFAVDLEGEHSAMDGRILEEHTEYVVYAIHRILDQYkeshlars 189  Japanese rice
Q9UT41    192 ------------------------TLNAGKLV--PDFFVVDFNEDFSAFHGQTLLDQAEYVNDAIPYILSLYrqnrki-s 244  Schizosaccharomyc...

Q9LTZ8    223 regaAASSKLPHDVILVGHSMGGFVARAAAVHPRLRKSAVQTILTLS-SPHQSPPLALQPSLGHYFAQVNREWKKG---- 297  thale cress
Q6C2Z2    225 ----SSHPNPPTSVIVIGHSMGGIVARTMVTLDSYIHGSINTILTLA-TPHVLPPVSFDKGIVGLYHNVNEFWKTE---- 295  Yarrowia lipolyti...
Q9KQA3     78 -----------TSVVVIGHSMGGKVA---MKLADIAAEKVRQLVVLDmSPVAYSQRRHD----NVFAGLEAV-------- 131  Vibrio cholerae
Q66J01    154 ----KNQTFPPESVAIIGHSMGGLVARALFTLKHFKPDLINVIITQA-TPHILPVLSTDIYLTDFYTMVNNYWI------ 222  African clawed frog
Q75T13    159 ----KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQA-TPHVAPVMPLDRFITDFYTTVNNYWILN---- 229  human
Q7PSQ5    153 -----GARGRTTRLFIVGHSVGGKLAQAVVGARTSIGRHVAGIVTLS-APVDKPVALFDHYHYSFYDRIEQAWRTN---- 222  Anopheles gambiae...
Q9W495    156 -----EGRTEQPSIVLIGHSMGGKLAQSVLVDPA-IGQHINTIISIS-TPLDQPVLNLDTQLEEFYDQTDAVLSKLrtat 228  fruit fly
CAP39834  168 --------RVKRRIVLIGHSYGGMVALLTTVHPDF-HDDIELVIVKG-APITKTPILNDWTTLRLNKLLTTKWDLL---- 233 
Q67TV0    190 kgraQSSDNLPSSVILVGHSMGGFVARAALVHPGLRKSAVETILTLS-SPHQYPPIALQPSLGQFFLHVNEEWRNG---- 264  Japanese rice
Q9UT41    245 seydNEAFPPPTSVILLGHSMGGIVAQATFTMKNYVDGSVNTLITLA-TPHAMAPLPFDRHLVEFYESIKNFWSQS---- 319  Schizosaccharomyc...

Q9LTZ8    298 -------------YEVQTSPGgnyv-sdplLSGVVVVSISGGYNDYQVRSKLESLDGIVPSSHGFMISSTSMTNVWLSME 363  thale cress
Q6C2Z2    296 -------------TVPGGK-----------LEDTLLVSVTGGIRDQMIPAEYSSVDTFLPPTNGFAVATTSIPDVWMSID 351  Yarrowia lipolyti...
Q9KQA3    132 -----------------------------------LVQKPTSRSEVMAILAQHIEQEGVRQFLGKSLMS----------E 166  Vibrio cholerae
Q66J01    223 -------------YNSLK------------LRNITMLSVAGGYSDYQVRSGLTFLPTSSFHTSALSVVSSAVPITWASTD 277  African clawed frog
Q75T13    230 -------------ARHI---------------NLTTLSVAGGFRDYQVRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTD 281  human
Q7PSQ5    223 -------------RSLAGAANaspshgllpLDGILFVTIGGGIRDIIVHDGLTA-----SRYADLHAMTHNIPNVWLSVD 284  Anopheles gambiae...
Q9W495    229 vptmttnvcdslhQRPPSVQRmasqdssarLDNVLLISTGGGNRDLLVRPGLTS-----SRFNDLHAMTSAIPKVSLSCD 303  fruit fly
CAP39834  234 -------------QASD-------------LKHVGVVAYTGGLRDFQIPDEWSIMRNVT---HRPIWAVGGVSDL--GAD 282 
Q67TV0    265 -------------YKTGLSRTss-----akLSNVVVVSVAGGIHDYQVRSKLALLDGIVPSTHGFMVGSSSMKNVWLSME 326  Japanese rice
Q9UT41    320 -------------FLLSPEENs--------LDDVLLVSIAGGGLDTHVVPEYSSISTFVPPSNGLMVFTSGIPSVWAEID 378  Schizosaccharomyc...

Q9LTZ8    364 HQAILWCNQLVVQVSHTLLSM 384  thale cress
Q6C2Z2    352 HQAMVWCHQLRRVVAETLLVV 372  Yarrowia lipolytica CLIB122
Q9KQA3    167 QNVMTW----RFNVAALKAHY 183  Vibrio cholerae
Q66J01    278 HLSIVWCRELVLVTARALFDL 298  African clawed frog
Q75T13    282 HLSIVWCKQLQLTTVRAFFDL 302  human
Q7PSQ5    285 HLCAMWCLQFVLVMNRFLFSM 305  Anopheles gambiae str. PEST
Q9W495    304 HLSAVWCLQFMQAINRFLFSV 324  fruit fly
CAP39834  283 HLAILWCNEFVRHVSRVLYFY 303 
Q67TV0    327 HQSILWCNQLVVQVAHTLLSM 347  Japanese rice
Q9UT41    379 HQAMAWCENFRRVLIRGIFAI 399  Schizosaccharomyces pombe 972h-
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