Conserved Protein Domain Family
Syntaxin-18_N
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pfam10496: Syntaxin-18_N 
SNARE-complex protein Syntaxin-18 N-terminus
This is the conserved N-terminal of Syntaxin-18. Syntaxin-18 is found in the SNARE complex of the endoplasmic reticulum and functions in the trafficking between the ER intermediate compartment and the cis-Golgi vesicle. In particular, the N-terminal region is important for the formation of ER aggregates. More specifically, syntaxin-18 is involved in endoplasmic reticulum-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER with the plasma or phagosomal membranes.
Links
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Statistics
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PSSM-Id: 463116
Aligned: 71 rows
Threshold Bit Score: 56.6552
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003224195   3 VDITLLFKASVKTVKtrnkalGvplGGgggsds----srddaLLLLKRSRPRSDFSSRAREVVNNIGKLKDFLLQHRKDY 78 
GAC95558      13 TDLTADFHSLIAQRRq-----Ey--PPssssaqp-sralrrkDPPENVVKAHKQWLRQAYIIRKHIISLLGFLYSIRRKY 84 
CCF54066      13 TDLTVDFQSLLAKRGq-----Dy--RPssssasa-lkplkrkDPPENVVRAHKQWLAQAYIIRKHIISLLGFLYSIRRKY 84 
KIS71911      13 TDLTADFQSLIAQRRq-----Ey--PPsasssaqgfgrlkrkDPPENVVKALKQWLAQAYIIRKHIISLLGFLYSIRRKY 85 
XP_007414590   5 TSRTLEFKEILQQH-------K---KNqnlskpinpkspiskTKPPSNLSETQTWSKEAKVVNHNIQDLLEFLKTIKRAY 74 
KDE09648       6 INRTNEFHEAVRSL-------G----ArypppsqassskskaARATPSPHADDAWTKQAEQVASNLQSFASFLHSIRRAY 74 
EEQ92026      74 TDITPLVRELLKAHgtrvtq----------------prsksgEEQRPSTETVDEFLKEAYRINAHITSLLTYLKSIRQSY 137
EEH03924      39 TDITPLVNELLKTHgttaiqs--------------rslartrEAQRPSTETVDEFLKEAYRINSHITSLLTYLKSIRQSY 104
EAW13847       2 TDLTPTLRRLLKEKhait--------------------tarpEPRLPSSETTDEFLKEAYRINFHITSLLSYLHSIRPAY 61 
XP_002148268   2 TDLTPSVQELLREKrkelat-----------------dteipQTPPRDPKNVNEFLKEAYRINSHIQSLLHYLQSIRHSY 64 

XP_003224195  79 INT--YSHAmsefvrMTDTERDQI 100
GAC95558      85 LALgkARTH------QLRADQDGT 102
CCF54066      85 LALgnKSRV------HHLREGQDG 102
KIS71911      86 LALgrRHAV------HLGQGVHGA 103
XP_007414590  75 LDPtpSR--------SSTTHHNST 90 
KDE09648      75 LDLgsTS--------SSAHHAHHP 90 
EEQ92026     138 LST--SPRS------HFSQNTHPH 153
EEH03924     105 LSTttPRA-------PFPHNGRSH 121
EAW13847      62 LALnpSTST------SSTSPSQPN 79 
XP_002148268  65 LSIhtTKKK------PDTTPAATA 82
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