Conserved Protein Domain Family
SEC1

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COG5158: SEC1 
Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion]
Statistics
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PSSM-Id: 227487
Aligned: 11 rows
Threshold Bit Score: 430.301
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
266998     1 MSDLIELQRNYLIG--VLNQIETKN------------------NLKFLIIDKTV----ETILSYLFLTPQELLNNVTSVD 56  baker's yeast
19073964   8 KMDILSLLKKKIIE--DVFKVHPDA------------------EWSVLVYDSYA----ASILKNFFVKSEFINHNIVISQ 63  Encephalitozoon cun...
19173048   1 --MLRELQKQRIK----AFLVAPNN------------------PWKILVLDSRT----QQIIGPLMKVSELRECGITAHF 52  Encephalitozoon cun...
19074397   1 ---MNDNLLGKKVD--EILDIGEG--------------------VKVLLFDEDT----KMILSNLIPHSRFLESDYFLFD 51  Encephalitozoon cun...
1175476    1 -MDLVSASQSYFKR--IFQEVS---------------------DLKILLLEEDT----TKIVSSCITQSNLLEQQIYLTV 52  fission yeast
19113002   2 TTDVKEKATFKLLD--LIDSVTG---------------------KKSLLLERDL----SGILGQIVTTNTLQEHGIPQVY 54  fission yeast
19075726   1 -MTLLELQKELFLS--KINSVECAT------------------KWKVLIVDTKT----ADIINHFITIHSLLEEKIAAVE 55  fission yeast
19075874   9 psSLREAQIQSLEK--LLNLNQDVNelesspq-----hasnfpIWKVLIFDKAG----SETISSVLRISDLRKHGVTVHM 77  fission yeast
134541    11 DISLRDMQISAILK--MLFLNKDLNnndnittitddifnqqeiIWKVLILDIKS----TATISSVLRVNDLLKAGITVHS 84  baker's yeast
1351402    3 LFDVADFYINKIVT--SQSKLSVANvne-------------hqRIKVLLLDKNT----TPTISLCATQSELLKHEIYLVE 63  baker's yeast
134528    14 NADGLCATLNEISQndEVLVVQPSVlpvlnslltfqdltqstpVRKITLLDDQLsddlPSALGSVPQMDLIFLIDVRTSL 93  baker's yeast
266998    57 LIDSPt--RKGQSSIEAIYILEP-TKYNINCIDADFMVR--PPKYRR-CHIRFLPGLTNPIFQFFQSKRYIAQnLESFKP 130 baker's yeast
19073964  64 RIEEK---REP-VDFPVIYFVKG-EDDVVKMINKDFEG------RL------Y-PTYTACVLEECEGLQPLIK----VLR 121 Encephalitozoon cun...
19173048  53 LVTQE---RHPISNTPAVYFV-----ESADGVLDDVLAElySEYYLN-FATSVTRGEIESLGLGLSERGLGLR-IRSVYD 122 Encephalitozoon cun...
19074397  52 SIMNKr--RERIQGITCMVAIRP---ESIRWLIEEVSN----PFYER-YIVLFTNQVDSLMLEILATSDVHCV-VSEIHE 120 Encephalitozoon cun...
1175476   53 LLGNK---REKLRHLKCVAFLRP-TPTTLRLLCEELRD----PKYAE-YHLYFTNVIPKSFLERLAESDDFEA-VKSIQE 122 fission yeast
19113002  55 WFNEN---IPNDIEKKTIYLCRP-TYENAKLVATHVRQFqrDMLRIE-STVIVLPTSNILFETVLQEEGVFGE--LLVTE 127 fission yeast
19075726  56 ILENP---RTPNSSFEALYILHS-EEKLVDCILKDEEy---DKRYPG-IHIVFLDMVKEPLINKLRTSRIASK-IRTVQV 126 fission yeast
19075874  78 NITSF---RQPIADVPAIYFVQP-TQENIELIIEDLSKGlyESAYVC-FSSTISRALLEQFAELASKTNTSHM-IHQVYD 151 fission yeast
134541    85 LIKQD---RSPLPDVPAIYFVSP-TKENIDIIVNDLKSDkySEFYIN-FTSSLPRNLLEDLAQQVSITGKSDK-IKQVYD 158 baker's yeast
1351402   64 RIENEq--REVSRHLRCLVYVKP-TEETLQHLLRELRN----PRYGE-YQIFFSNIVSKSQLERLAESDDLEA-VTKVEE 134 baker's yeast
134528    94 RLPPQlldAAQKHNLSSLHIIYCrWKPSFQNTLEDTEQWqkDGFDLNsKKTHFPNVIESQLKELSNEYTLYPWdLLPFPQ 173 baker's yeast
266998   131 IELGFFVKESQFFETLQ-MEHSLQVFFNNNCKALIptnvrKIVGSLVSLCVITGEYPIVRYSVSnpveeedarnGNAVVN 209 baker's yeast
19073964 122 VDVDFIPFEQKVFRAMP-KQLYSVAKTLNT--MFN-------VSYTGSTCRSLG-----------------------EMA 168 Encephalitozoon cun...
19173048 123 QFVDFIALQDDMFTLGM-KGSFIEMENPDT--WRR------MVMSVMSVFVTLGEVPFIVATDD----------DVTTQM 183 Encephalitozoon cun...
19074397 121 IYIDFFKQDDFLYTLHA-PKTREHMSLSGR--KRS-------IDGIFALVMNLGRIPTIKIQT-----------EDRHLM 179 Encephalitozoon cun...
1175476  123 FFLDYLVVNNDLASFNI-PHIIEDSPDNWQDGAFH-----RTHQGIISLLLSLKKKPVIRYDNNs---------LLCLKL 187 fission yeast
19113002 128 WPLHAVPLDKDLLSLELgPEKLEESLLQRS--TDA----------LIDFERTHGRFPRVSGRG-----------PYAAKM 184 fission yeast
19075726 127 AYLDFTSLESRYFQVHD-SFSGLRLYHPSN-AAIIrqelsKVAHGIFSVCVSLGISPNIRCYYP----------KNAPHA 194 fission yeast
19075874 152 QYLNYVVLESDFFSLQL-PKIFHTFHNPSSDEALInsrvqDIVNGLFSVIVTLGTIPIIRCPQG----------SAAEMV 220 fission yeast
134541   159 QYLDFIVTEPELFSLEI-SNAYLTLNDPKTTEEEItglcaNIADGLFNTVLTINSIPIIRAAKG----------GPAEII 227 baker's yeast
1351402  135 IFQDFFILNQDLFSFDLqPREFLSNKLVWSEGGLT-----KCTNSLVSVLLSLKIKPDIRYEGAs---------KICERL 200 baker's yeast
134528   174 IDENVLLTHSLYNMENVnMYYPNLRSLQSATESILv---dDMVNSLQSLIFETNSIITNVVSIGnl-------sKRCSHL 243 baker's yeast
266998   210 ANSLTRSIANAFQIAIDTYARNNPdfppqnterPRSILIITDRTLDPFAPILHDFSYQAMAYDLVANVDTQKDIYHYSAe 289 baker's yeast
19073964 169 EKMMGDEER-------------------------KGELIILDRSIDLFTPLLHFFTFRTLLEDLEIENMEVFEK------ 217 Encephalitozoon cun...
19173048 184 ARMLETKIR-----N-TGVIKRGS---------KRPVLVLVSRSHDVITPVQHVWSYSALMNDLFALESNKITL----K- 243 Encephalitozoon cun...
19074397 180 EDSETLSTR---LAGLN---LKQ-----------GGTLIMLDRAFDLYTPLLYEWRYQSLLHEHADYANGIVRIG----- 237 Encephalitozoon cun...
1175476  188 AEEVSYTIQ-HESQLFNFRKPDT-----------APILLLLDRKNDPITPLLTQWTYQAMVHELFGIDNGRVSFSNSTSd 255 fission yeast
19113002 185 LELLEKTYQEEATINFGKVEGEISa--------LYDSVLLVDRSLDRITPFLTQLTYFGFLDEILGIQQMNVKLPSSLVn 256 fission yeast
19075726 195 SKTMSFILANQLSEIVEEYCSKHPgyh---eaaSKSTCLIVDRSLDTAAPFLHEFTYQAMIHDLLPIKNEQYPYEILGP- 270 fission yeast
19075874 221 AQKLNQRLKDHLMNTKDAFVSVNPk--------PRPILILLDRTVDLIPMINHSWTYQALIHDTLNMQLNRITV--ESVd 290 fission yeast
134541   228 AEKLGTKLRDFVINTNSSSTSTLQgnd----slERGVLIILDRNIDFASMFSHSWIYQCMVFDIFKLSRNTVTIPLESKe 303 baker's yeast
1351402  201 AKEVSYEIGKNERTFFDFPVMDS-----------TPVLLILDRNTDPITPLLQPWTYQSMINEYIGIKRNIVDLSKVPR- 268 baker's yeast
134528   244 LKKRIDEHQTENDLFIKGTLYGERtn-----cgLEMDLIILERNTDPITPLLTQLTYAGILDDLYEFNSGIKIK------ 312 baker's yeast
266998   290 neAGe------qEEKVSKLVDLYDPDWIDLKHQHIMDANEYIQGRIKELIAKNPLLVd-----------RSNVKNTTDLL 352 baker's yeast
19073964 218 -------------------EYMGDRVWESVKNVHLGEVNSILRNQAQMLSKVAQRLD------------TK--VDNKDLM 264 Encephalitozoon cun...
19173048 244 --SG-----------KVFDLDPQDELWRRNANEYFPVVVERVEKELLEYKKEMALRS------------IDEKTDKKVIQ 298 Encephalitozoon cun...
19074397 238 ---------------KKSYSVADDPFFNASKFKDIYEVSEDIKGLVKKVEFKKKRLH----------------------N 280 Encephalitozoon cun...
1175476  256 --NE--------KSTEIVLNPTLDPFYKETRFDNFGDLGVKIKDYVSHLQTKSTKKA------------SEI-ESIADMK 312 fission yeast
19113002 257 rnEAsn----tgPMKKFSLSSSSSQITKEIRDINFNCIGPYLSKIARKLSSDFEGRR-------------Q-AKTVNQIR 318 fission yeast
19075726 271 --QG--------TEKRTGKLDDDDLVYTTIRHMHMRDAIEKLMKDFNQFCIDNTLFLd-----------KERATSLNDMR 329 fission yeast
19075874 291 --DGk-------MTKRFYDLDGNDFFWESNASKPFPKVAENIDEELTRYKNDASEITrksgvssleevnVDAFADSTYLK 361 fission yeast
134541   304 --NGtdnttakpLATKKYDIEPNDFFWMENSHLPFPEAAENVEAALNTYKEEAAEITrktgvtnisdldPNSNNDTVQIQ 381 baker's yeast
1351402  269 --IDk-------DLEKVTLSSKQDAFFRDTMYLNFGELGDKVKQYVTTYKDKTQTNS------------QIN--SIEDIK 325 baker's yeast
134528   313 -------------EKDMNFNYKEDKIWNDLKFLNFGSIGPQLNKLAKELQTQYDTRH------------KA--ESVHEIK 365 baker's yeast
266998   353 SVVAHLKDFDEERRRLILHKTLVDECLGENAERKLADISAIEQNLSGFGMDfsgekiKHIIDDLLPALAMKEPTIl-DKL 431 baker's yeast
19073964 265 KMVLEAPAAAKTKESLGKILGLAQKCYDRFD--YLSRFNEIEQLLATGYDKsgn-kwKMKIDDVFEYFRSSRIERs-DKV 340 Encephalitozoon cun...
19173048 299 EALDKAPELAKRNESVNAHISICSEMVEMIKERAIDDFYKVEKGGHTNQ-------------ELIELSEKGSDED---VL 362 Encephalitozoon cun...
19074397 281 FIFDDLEENTRISRQLEAHLAQHGHVMKACLR--LKDLSEMEMNVLKDNGVs-----KAEISECLTRKDISVIER----C 349 Encephalitozoon cun...
1175476  313 QFLEAYPEYRRLSGNVSKHVSLVSEISQVVQRENLLEVGEVEQSLVCNEPQ------STDFNDIQRLLFSNISEN--TKL 384 fission yeast
19113002 319 DFVSKLGSLQSEHTSLNIHTGLAETLVQHTKNNYFQKLLQLQHLLVSHADSf----tQFNLLDEIIYAEAPVEEV----F 390 fission yeast
19075726 330 SMLAGLSDFQELRDQYSLHLTMAQECMNIFEKQQLNLIGAIEQDLSTGSNVegk-vpRSVLSELLPLLDEGNAEEs-TKI 407 fission yeast
19075874 362 SAVSLLPELTARKQILDMHMNIATALLKAIQERHLDDFFQLEDNITGLN--------RSAILACINNKEQGTPED---KL 430 fission yeast
134541   382 EVVKKLPELTAKKNTIDTHMNIFAALLSQLESKSLDTFFEVEQDPGSTKT-------RSRFLDILKDGKTNNLED---KL 451 baker's yeast
1351402  326 NFIEKYPEFRKLSGNVAKHMAIVGELDRQLKIKNIWEISEIEQNLSAHDAN------EEDFSDLIKLLQNEAVDKy-YKL 398 baker's yeast
134528   366 EFVDSLGSLQQRQAFLKNHTTLSSDVLKVVETEEYGSFNKILELELEILMGnt---lNNDIEDIILELQYQYEVDqkKIL 442 baker's yeast
266998   432 RYIIAYALFRGG----IIELDFIKLLNFIGVTHEHENFQQYLKIFRNYDLIDFKLIKDKPKDKpfqkewfhDTLVNDPNI 507 baker's yeast
19073964 341 RILLLLKANGYQ-----LQETEMDLLRGMGFRDEEIRITFDN----------HENFVPLRGTG--------------DYK 391 Encephalitozoon cun...
19173048 363 RLAILLLNTKDF------D-LIDPLLRKRKIKSKAIEFFRRH---------G-GTRSEKLGT----------------L- 408 Encephalitozoon cun...
19074397 350 KLLIIYSLRNKK-----NPIDEARKYPDLMNEVEAFMGRHPLN----------VPIWRHYGY------------------ 396 Encephalitozoon cun...
1175476  385 RLAALYSLRFERid-pAKVSALQQMLIAGGVNPLKVSVIPTL-----L---HVAGYSFRQGD-----------VFPPSNL 444 fission yeast
19113002 391 RVLCLASITTNGl--rRKDIDHYRREITQTYGYYHLLTFQALIDAGLLRLRQSTNISLQKSLS----------YSTWLNT 458 fission yeast
19075726 408 RLLLLYIIYRDG----IILQDLFRLFRHSNLSTSREQIFQNLEQLGTRVIKNLTDQSSKRKEVa-------NSLPAGEDV 476 fission yeast
19075874 431 RFFIIWYLSVDSvp-aSDLQAYEEALVNNGCTLEALNFVKRVREITKMTMLASSTTRPATGQTg-------DNLFRGFSS 502 fission yeast
134541   452 RSFIVLYLTSTTglpkDFVQNVENYFKENDYDINALKYVYKLREFMQLSNMSLQNKSLEDGS---------DSAFK-PSN 521 baker's yeast
1351402  399 KLACIYSLNNQTs---SDKIRQLVEILSQQLPPEDVNFFHKFKSLFSR--QDKMTQSNHDKD---------DILTELARR 464 baker's yeast
134528   443 RLICLLSLCKNSl--rEKDYEYLRTFMIDSWGIEKCFQLESLAELGFFTSKTGKTDLHITTSKstrlqkeyRYISQWFNT 520 baker's yeast
266998   508 YHTSRFVpavg-nilsKVIANPLLLSEQYFPYLKDKPIELLNEEEFQAGLANTSa---nSssSLRNPRHKaa----wTtK 579 baker's yeast
19073964 392 YEVS------------RYEPVLSNVLRSFIGKQKGHFQINRLTSSRTPLKSLRK--------SHLLSVKK---------- 441 Encephalitozoon cun...
19173048 409 YS--------------QVVTSLMGNVKKLLPVKEQTPISSLVETIYGDIKSQIY-----S--GLRVFDSM-------G-- 458 Encephalitozoon cun...
19074397 397 -----------------RFDDDVDVKLGYQPAIKRVIRHWWTNRLDNRCFLTVR-------------ESE---------- 436 Encephalitozoon cun...
1175476  445 FSRARSGl--------KGLRGVENVYIQHNPFLKSILLDLIQGRLKETTHPFLN--------SETRAQTS---------- 498 fission yeast
19113002 459 YPLVKDEvd------eQNPEDIAYTYSGYGPLSVHIAYDILKGRDNEEKILKLQnmpgtYvdKWTLDQEK-------VmP 525 fission yeast
19075726 477 YELS------------RYVPTLKVVLENLIQDKLDPELFPYVRNTTPQTEVSME-----Qt-SLRSSRPS-------WtR 531 fission yeast
19075874 503 LSTRFTDrfke--agiGGLENIISGVRNLIPFRKDGTITSIVQSLMDPGSSPASk----QteSYLLLDPKsaraitvNnD 576 fission yeast
134541   522 LTLSGIYglte-gklqGGVGSLISGIKKLLPEKKTIPITNVVDAIMDPLNSSQKnl--eTtdSYLYIDPKit----rGsH 594 baker's yeast
1351402  465 FNSRMN----------SKSNTAENVYMQHIPEISSLLTDLSKNALFRDRFKEIDt----Q--GHRVIGNQ---------- 518 baker's yeast
134528   521 VPIEDEHaadkitnenDDFSEATFAYSGVVPLTMRLVQMLYDRSILFHNYSSQQ--------PFILSREP---------R 583 baker's yeast
266998   580 SSNIkKNIPRQRFFYYVIGGISIPEIKAAYDQSNLKN----RDIFIGSDEILTPTKFLDEVERLQNPRE 644 baker's yeast
19073964 442 ---D--ISCQKLYCVYIAGGVTFEEIRVAYEVGESLG----VEIVVGSDKIITPRSYVEYLKARCT--- 498 Encephalitozoon cuniculi
19173048 459 SKSI-YASEISRLVVFGVGGGTYTELKTLKLLEERIG----VPIIYGSTEILNAREFLRQVEGRMSLD- 521 Encephalitozoon cuniculi
19074397 437 ---N----PMDYIVVYIRNGVTYSEYRVLCEYYNTA-----M---KGRSELYVVGDVMVSYKDIMGASS 490 Encephalitozoon cuniculi
1175476  499 ---N---EKPQDIIVVIVGGATYEEAHFVSEFNATQPg---VRIILAGTTILNSTAYIDDIMYMSTRIK 558 fission yeast
19113002 526 KNLKtNVPGKRRVLVFFIGGCTYTELAAFRLLQEKEDl---YEFTFMTTGMVTGSSLIRAFIPNIESLN 591 fission yeast
19075726 532 SRSMaSKLPREKMLVFVAGGTTFSELRTCYELSDKYN----KDIYIGSTVCYSPNEWLDFFSKFQQPRE 596 fission yeast
19075874 577 PRAMnKRQTFSEAIVCVLGGGNYLEYGNLADWAREQnp--kKRIIYGSTDILSPSEFMEEMASLS---- 639 fission yeast
134541   595 TRKP-KRQSYNKSLVFVVGGGNYLEYQNLQEWAHSQLhnpkK-VMYGSTAITTPAEFLNEISRLGASNS 661 baker's yeast
1351402  519 ---Q-SKDIPQDVILFVIGGVTYEEARLVHDFNGTMNn--rMRVVLGGTSILSTKEYMDSIRSAK---- 577 baker's yeast
134528   584 VSQTeDLIEQLYGDSHAIEESIWVPGTITKKINASIKsn-nRRSIDGSNGTFHAAEDIALVVFLGGVTM 651 baker's yeast
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