3IZR,3U5B 3U5C 3U5D 3U5E 3U5F 3U5G 3U5H 3U5I


Conserved Protein Domain Family
KOW_RPL6

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cd13156: KOW_RPL6 
Click on image for an interactive view with Cn3D
KOW motif of Ribosomal Protein L6
RPL6 contains KOW motif that has an extra ribosomal role as an oncogenic. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4.
Statistics
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PSSM-Id: 240520
Aligned: 65 rows
Threshold Bit Score: 143.072
Created: 22-Aug-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:3U5E; Saccharomyces cerevisiae ribosome, contacts 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      # #               ##### #           ##      ##### # #### ##                     
3IZR_G                                      67 HPTKLRSTITPGTVLILLAGRYMGKRVVFLKQLQs-GLLLITGPFKINGVPIRRVNQAYVIATSTKVDISKVNVq---KF 142  bread wheat...
3U5B 3U5C 3U5D 3U5E 3U5F 3U5G 3U5H 3U5I_3   26 RPQKLRASLVPGTVLILLAGRFRGKRVVYLKHLEd-NTLLISGPFKVNGVPLRRVNARYVIATSTKVSVEGVNVe---KF 101  Saccharomyces cerevisiae S288c...
XP_657157                                   51 NLEKLRKSIVPGAVLIIVAGKYAGKKVVFLKQCIksGALIVTGPFKINGVPLMRINQRYVIATSQKVDVSKVDTt---GV 127  Entamoeba histolytica HM-1:IMSS...
CBY10035                                    42 SEKKNSCNLEAGRILILLTGRHRGKRVVFIKQLRqsGLLLVTGPYCINGVPLRRVHQKTTITTSSILPISEAHFkvppFV 121  Oikopleura dioica...
4590448                                     22 EYTTLRKSCAPGAIAIILAGRFRGRRAVILKQLPhnGPLVVSGPMKYSGVPIRRIDSRYVIATSTKVDISSVDTs---SI 98   Leishmania braziliensis...
GAA30366                                  1119 RWKVRSSLRKRGVIVILLGGRHRGKRVVSLGRQKstGLLLVTGPFRYNGCPLRRVHPNMVLATQTRVDLGKFKVp--lRV 1196 Clonorchis sinensis...
CBK25409                                    20 NAPKLRATITPGTVLILLAGRHAGKRVVFLKQLAs-GLLLVSGPYKMNKVPLCRVHQSRVIATSTKLDIGSVKIp--tSV 96   Blastocystis hominis...
CBK20390                                    20 KPTKLRASITAGTVLILLAGRYAGKRVVFLKQLAs-GLLLVSGPFTLNKVPFLRVNQCHVIATSTKIDISGLKVp--aTL 96   Blastocystis hominis...
CBK22250                                    20 KPCKLRESIKQGTVLILLSGRYAGKRVVFLKQLAs-GLLLVSGPKSVNRVPLIRVPQSRVIATSTKLDISSLDLs---IN 95   Blastocystis hominis...
ADZ95710                                   665 NHRERRTDLSLGDIVVVLEGEFEGKRVVYLKQLEn-NLALCTGPSKINGVPFFKIDERYLLATSTHVDYNGVIDv---DE 740  Nosema bombycis...
Feature 1                                             #                                      #  ##                        #  ##
3IZR_G                                     143 DDk-YFAREKktrakktegel--------------fesdkeatknlPDFKKDDQKVIDAELIKAIDa---vPDLKNYLGA 204  bread wheat...
3U5B 3U5C 3U5D 3U5E 3U5F 3U5G 3U5H 3U5I_3  102 NVe-YFAKEKltkkekkean----------------lfpeqqnkeiKAERVEDQKVVDKALIAEIKk---tPLLKQYLSA 161  Saccharomyces cerevisiae S288c...
XP_657157                                  128 DVk-FFKKIAikkaafgktve--------------edfakkqyeakKALIVEKQKQVDESIVAEIKk---vPYLKEYMAS 189  Entamoeba histolytica HM-1:IMSS...
CBY10035                                   122 NDs-FFCAKTkekkvsvdavle-------------nsekkeseaklSEERKLLQRQVDEAALESIRs---iPFMKDYLSQ 184  Oikopleura dioica...
4590448                                     99 TPe-VFLRPKaekptkcegdfmgdkqkakaeksakktskaekktvvSDARAQLQKKIDAALVAAIKkdaqgKEKAGYLRS 177  Leishmania braziliensis...
GAA30366                                  1197 HSkeYFARKKldnkhdldaqlgls---------gapdsaeskrfvpSEERKEDQRIIDEEVCKCIKahadsRMLIKYLRS 1267 Clonorchis sinensis...
CBK25409                                    97 NDs-FFNGKKs-----------------------------------PEEKKATQEAVDVEVVKSIEg---vPMMKEYLSS 137  Blastocystis hominis...
CBK20390                                    97 DDs-YFSNSSakkni---------------------------destKKERKALQESVDAELMKCIEk---vPMMKEYLHG 145  Blastocystis hominis...
CBK22250                                    96 DT--FFSSKN------------------------------------TENKEATQKTVDDKLEACIEk---tPLMKEYLHA 134  Blastocystis hominis...
ADZ95710                                   741 SSv-ILTDREesi------------------------------ermETEGDEKMEMIDSTIINVIEk---vDFLKAYLAD 786  Nosema bombycis...
Feature 1                                      #   ##         
3IZR_G                                     205 RFSLRDGDKPHEMTF 219  bread wheat
3U5B 3U5C 3U5D 3U5E 3U5F 3U5G 3U5H 3U5I_3  162 SFSLKNGDKPHMLKF 176  Saccharomyces cerevisiae S288c
XP_657157                                  190 YFTLKNGDHPHLLKF 204  Entamoeba histolytica HM-1:IMSS
CBY10035                                   185 KFSLSKNQMPHKMNF 199  Oikopleura dioica
4590448                                    178 VFTVKPGDAPHRWNW 192  Leishmania braziliensis
GAA30366                                  1268 LFSLSKHDKPHAILF 1282 Clonorchis sinensis
CBK25409                                   138 RFCLSKRSRPHEMKF 152  Blastocystis hominis
CBK20390                                   146 RFLLSGRSVRVHDMT 160  Blastocystis hominis
CBK22250                                   135 RFVIGKGSRPHDMKF 149  Blastocystis hominis
ADZ95710                                   787 DFVADPSVDFYSQKY 801  Nosema bombycis

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