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LYR motif-containing protein 2-like This entry represents LYR motif-containing proteins, including LYR motif-containing protein 2 from animals, whose function is not clear, and Cup1 (caffeine unstable phenotype 1, previously known as uncharacterized protein C17G9.13c) from S. pombe. Cup1 has been characterized; it is a mitochondrial protein whose silencing by heterochromatin island formation results in caffeine resistance. LYR-motif containing proteins are basic polypeptides carrying a conserved tripeptide L-Y-R (leucine/tyrosine/arginine) sequence close to the N-terminus in addition to some basic arginine/lysine residues and a highly-conserved phenylalanine downstream of the LYR motif. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",