Conserved Protein Domain Family
Cmc1

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pfam08583: Cmc1 
Cytochrome c oxidase biogenesis protein Cmc1 like
Cmc1 is a metallo-chaperone like protein which is known to localize to the inner mitochondrial membrane in Saccharomyces cerevisiae. It is essential for full expression of cytochrome c oxidase and respiration. Cmc1 contains two Cx9C motifs and is able to bind copper(I). Cmc1 is thought to play a role in mitochondrial copper trafficking and transfer to cytochrome c oxidase.
Statistics
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PSSM-Id: 400756
Aligned: 46 rows
Threshold Bit Score: 47.7215
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9NRP2         1 MHPDLSPHLHtEECNVLINLLKECHKNhNILKFFGYCNDVDRELRKCLKNEyvenrtKSREHGIAMRKKLF 71  human
Q0IF43        42 IPKIMRERAKtEKCIPEVQDFETCCKD-SGLLMAMKCQKQNEALKTCSLRWyndeqfKSECTEIYLAERSE 111 yellow fever mosquito
Q4RFB6        20 IPKLMREKAK-ERCAEKVEAFTHCCKE-SGFFMVFKCREENTAMKECLTAHykdpsfFEECKQEYIEEKLE 88  spotted green pufferfish
Q9CPZ8        19 IPKIIREKAR-ERCSEQVEDFTRCCKD-SGILMVLKCRKENSALKDCLTAYyndpafYEECKLEYLKEREE 87  house mouse
XP_001638346  10 IPKLVREKAR-ERCKDLVDEFEKCCKG-RSISMVWHCRKQNTAMKDCLTKNyqdkelFEACRVEYLQKRRQ 78 
Q6C7C2        42 VREETRRLAR-IACADVLKVFSDCTKG-RTVSMLWACRIEKANMMECMASHstm-edfDRARDEFVQKKAD 109 Yarrowia lipolytica
Q5KJR5        12 IHEAAKKEAL-RSCDDYVKDFADCATG-RTFSLPFMCKTRLNAMQGCMRDYmtq-ermDAMKLDFIAHRSE 79  Cryptococcus neoformans
XP_001542188  40 VRDLYYKRVR-GHCAAEIKEFAACAIN-RTVTATWVCRKQRLAMNACMVEHakp-eeeDRAREEWFTSREE 107
XP_001592998  35 VQEVYHTRVR-SYCAAEIKTFAECALG-RTFTAPFKCREQNRAMNNCMITHatq-sekDAAREEWFSLRLQ 102
Q7SDV5        52 VRDIFYARVR-RQCTEEIKAFAECALG-RTFSVPFACRAPHRVMNNCMKLHatp-aeqDAAREEWFALRME 119 Neurospora crassa
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