Conserved Protein Domain Family
AKR_AKR13A1

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cd19144: AKR_AKR13A1 
AKR13A family of aldo-keto reductase (AKR)
Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Statistics
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PSSM-Id: 381370
Aligned: 7 rows
Threshold Bit Score: 568.227
Created: 13-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rauvolfia serpentina perakine reductase (3V0T) in complex with 2'-Monophosphoadenosine-5'-diphosphate.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           #                                                         
Q09923      3 IPTRKIGN----DTVPAIGFGCMGLHAMYGpss-eeaNQAVLTHAADLGcTFWDSSDMYGfgaNEECIGRWFKqt-grRK 76  fission yeast
EGX50180    8 IPTRHLGKn--gPSVSELGYGAMGLSIGYGpakpdehRFKMLDAVIESGiYFIDTSDIYGd--SEELIGRWFKqnpglRE 83  Arthrobotrys oligo...
ODQ69572    3 FPTTTLGKd--gPEITALGYGAMGISAFYEphltdeqAFPLFDKLLELGcTFWDTARIYGd--NEEILGRYFAkt-gnRS 77  Lipomyces starkeyi...
PRP86261    3 LQTRALGKn--gPQVTALGFGTMGLSAFYGppkpdneRFAVLDAAFAAGeLNWDSADIYMd--SEDLLGRWFAanpgkRE 78  Protostelium sp. J...
POF16489   20 LPTARLGRh--gPEVTRLGYGTMGLSAFYGtpkpdaeRFAVLDKVYAEGdLFWDTADMYQd--SEDLLGAWFKrnpgkRD 95  Quercus suber
CEO94641    7 VQRVQLGRg--gPMVPAMGLGAMGFSSSYGgrpseadALRTLQHAVDIGcTLIDTADVYGp--HTNEILVGKLlatrtRS 82  Plasmodiophora bra...
SJL06579    1 MSTTTLQRkignTSVPVIGFGAMGISAGYGsiepdeeRFKVLDAAFEARcTFWDTADVYLd--SEDLIGKWFKrnpgkRE 78  Armillaria ostoyae
Feature 1                                                                                     
Q09923     77 EIFLATKFGYeknpetg-elslnnePDYIEKALDLSLKRLgIDCIDLYYVHRFSgetPIEKIMGALKKCVEAGKIRYIGL 155 fission yeast
EGX50180   84 KVFLATKFGIkmdrsng-afwadgsPEYVKTAVESNLKRLdIDYIDLYYVHRIDskiPIELTMGALKELKQAGKIRHIGL 162 Arthrobotrys oligo...
ODQ69572   78 KVCLCTKVGYkapvvgggipspsgePEFIRNSCEQSLKRLgVETIDLYYQHRIDttiPIENTIAGFAELVKEGKIRHIGL 157 Lipomyces starkeyi...
PRP86261   79 KIFLATKFGGyriqedgqrgptdssPEYCKKAIERSLKRLgLPYVDLYYAHRLDgktPVEKTVAAMAELKAEGKIKHIGL 158 Protostelium sp. J...
POF16489   96 TIFLASKFANcvnketg-erwvdssPEYCRKACETSLSRLgVSHVDLYYAHRLDgktPVEKTMQELKKLKQEGKIKYIGL 174 Quercus suber
CEO94641   83 DIFVCTKFGIekvvpa---yavngsPEYVNAACAASLQRLgVDQIDLYYLHRVDpkvPIEKTVAAMAELVQQGKVKHIGL 159 Plasmodiophora bra...
SJL06579   79 SIFLATKFGItmqg-------trgdPEYVKEQCYTSLKRLgVDYIDLYYQHRVDpstPIETTVKTMAELVKEGKVKYLGL 151 Armillaria ostoyae
Feature 1                                                         ####  #                     
Q09923    156 SECsANTIRRAAAVyPVSAVQVEYSPFSLEIErpeigVMKACRENnITIVCYAPLGRGFLTGAYKSPDDFPegDFRRKAP 235 fission yeast
EGX50180  163 SEAsAETIRRAHAVePLAAVQLEYSPFAIDIEepernVLNTCRELgIATVAYSPLGRGFLTGRYRSTEDFEpgDFRTYAP 242 Arthrobotrys oligo...
ODQ69572  158 SECsAETLRRAYKIhPIAAVQIEYSPFSLDAEtn--gVIDACKELgVAVVAYSPLSRGFLTGAYTSPEDFEpnDVRRRLP 235 Lipomyces starkeyi...
PRP86261  159 SEVsAESLRRAYKVhPIAAVQIEYSPFTLDIEdpqiaLLQACRELgVAVVAYSPLGRGMLSGKIRSPDDFAadDFRRFAP 238 Protostelium sp. J...
POF16489  175 SECsSESLRRACSVeHVDAVQIEYSPFSLDIEsaqigLLKTARELgVAIVAYSPIGRGMLGGSIRSPSDFEegDFRKNAP 254 Quercus suber
CEO94641  160 SEPsAATIRRAHAVhPITAVQVEYSPWTTDIErn--gIMDTCKELgIAIVAYSPLGRGFLTGTISSPTDLEekDWRRMNP 237 Plasmodiophora bra...
SJL06579  152 SDCtASGLRRAHAIhPISALQIEFSPFILDVEkppleLIQTARELgVKIVAYSPLGRGLLTGQIRSRDDLEptDFRLTVP 231 Armillaria ostoyae
Feature 1                                 #                 #####  #  ##                      
Q09923    236 RYQKENFYKNLELVTKIEKIATANnITPGQLSLAWLLAQgdDILPIPGTKRVKYLEENFGAlkVKLSDATVKEIREACDN 315 fission yeast
EGX50180  243 RFSKENFPKNLELVDGIKALADKKgVTAAQLTLAWVLSRgdDVIPIPGTTRLEGLEENLGSlkVELSEEEKKEVERLAKE 322 Arthrobotrys oligo...
ODQ69572  236 RFQAENFPANLELVNKLKAIADKKgVTTGQISLAWLMAQ--GSIPIPGSTKLARIEENVASvdIKLTEEDLKTIREYVDA 313 Lipomyces starkeyi...
PRP86261  239 RFAPENFPKNLTLVDEISRIAEKKnITASQLTLAWLLAQgdDIIPIPGTTSIDRLKENLGSlsVQLTEEEKKAVRKLAEE 318 Protostelium sp. J...
POF16489  255 RFSEENFPKNLQLVDTITAIAKKRnVTASQLTLAWLLAQgdDIFPIPGTTNLNRVEENLGAlhIKLSREEELEIRKACEA 334 Quercus suber
CEO94641  238 RFAEEAMKKNMELVDALKSLASKKnVTPAQLTLAWVIAQ--GCIPIPGTTKASRLDENFAAlnVEITASDEKAIRDIIAK 315 Plasmodiophora bra...
SJL06579  232 KFNAENFSKILSLVDRIGDVAKRHdATSGQAALAWILAQgeDFFVIPGTKKIKYLKENLGAgsLKLTPEEIAEIRQIAEE 311 Armillaria ostoyae
Feature 1             
Q09923    316 AEVIGARY 323 fission yeast
EGX50180  323 CVPVGERY 330 Arthrobotrys oligospora ATCC 24927
ODQ69572  314 ANIVGGRY 321 Lipomyces starkeyi NRRL Y-11557
PRP86261  319 AEVHGTRY 326 Protostelium sp. Jena Gg-2016a
POF16489  335 AEVAGSRY 342 Quercus suber
CEO94641  316 FPVVGPRY 323 Plasmodiophora brassicae
SJL06579  312 TEIPGERY 319 Armillaria ostoyae

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