Conserved Protein Domain Family
DUF1746

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pfam08508: DUF1746 
Fungal domain of unknown function (DUF1746)
This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins.
Statistics
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PSSM-Id: 430039
Aligned: 63 rows
Threshold Bit Score: 78.7525
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK42397      48 SIQVVEVVLIIIIYLRDVS-FFKLIIRYVVHLSIKAIDPHHIiQNfGmsgqnallsgehrrsMVKISLRGLLLGNLFCLL 126
XP_001482297  46 sflALGYILLGIMYLRDNS-LVLLVVKFNMHYRVSLCRGNGKeTStD---------------EAMMIGQRTIATYLFSLA 109
EEQ36786      40 lmgtLGYVFIAMAYLRDFS-LVLFILRCTLQFLLSEPFPNvgpefgs--------tfnikegQARFLMRSVLIFNGICLF 110
XP_013933100  33 rLDVSCYLALIILYLADEN-LILLLLRGFQQFMLGHPPNSieasavl--------tpaiqriLAQKVLSLGLAFNVLGLI 103
KDE05342      93 SLDAIIWILFVHSYLLSPShLLTFLLRLFSHVQFSSSRKIHPaRSlC------------------HLLSVWFFVNASSVI 154
CCF48282      11 SLDLLCFVLFVYTWLLDNR-TFLLVVKAALQVQFCNAVQMHPtWSlP------------------FLVVFLCSLNLIFAL 71 
GAC94782      11 SLDLLCFVLFVYTWLLDNR-TFLLLVKAALQVQFCNPLQICPtWSlP------------------FIVVFLCSLNLTWAL 71 
KIS67528      11 SLDLLCFILFVYIWLLDNC-TVPLIIRAALQVQFCNPSLMHPtWTlP------------------FFVVFLCCLNLIFAL 71 
XP_016293851  11 SLDLLCYVLFVYTWLLDNR-TLSLLFRAVLQWQCHNSIHIQPtWTlP------------------FLVVFLSGINGIFAL 71 
GAC77680      78 SLDLLCFVLFVYTWLLDNR-TLLLLIKSALQVQFCNPLQLHPtWSlP------------------FFVVFLACLNALLAL 138
EDK42397     127 SHLLLGVRTQKVgvfGDE-YLYGGMNVMFIGEKLPLLRFE----IVAFDLAIFATQLIF 180
XP_001482297 110 YHLIFGVFKTY----TNDhLLHGSLTLQFIGESPASSRFE----LIFYDIITFAV--IW 158
EEQ36786     111 VHLIFPLPVSPL---PSGhYYYGSSSMQFIGESAPCTPWG----ILAYDVATFFLQLVY 162
XP_013933100 104 VHIAFSARGGL----GQG-ISYGAYIINIMGENRFEGWFHkllyLLLWDFVLVALQfsl 157
KDE05342     155 VHAWQGSRGTK----GTKrWSSTGLIVDFVGQAITPSKSH----LVLLDLLIALSQFVl 205
CCF48282      72 VHLLTPASQTN---------SQDAMLIDFVGQVTLPGRVQ----MFFIDALVCFVQLLM 117
GAC94782      72 VHLWTPASKTN---------TGESILIDFVGHTTLPGRLH----MLLIDAVVWGAQLLM 117
KIS67528      72 AHLWAPPSTTN---------AGTAILIDFVGHTTLPGRLH----MLFIDALVWFVQLVM 117
XP_016293851  72 AHLWSPPSITN---------TGEALLIDFVGHSYLPGRLQ----VLTIDMGIWFIQLLl 117
GAC77680     139 AHLWAPASATN---------RGDAILIDFVGQDAAPGRLH----MLGIDLCVAAVQLLM 184
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