Conserved Protein Domain Family
Nkap_C
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pfam06047: Nkap_C 
NF-kappa-B-activating protein C-terminal domain
This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency.
Links
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Statistics
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PSSM-Id: 461812
Aligned: 33 rows
Threshold Bit Score: 142.004
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007396901          328 ERQYGGALLRGEGSAMAAFLKDGTdvRIPRRGEIGLTSGEIATFENVGYVMSGSRHRRMNAVRMRKENQVISAEEKRGIL 407
XP_001731050           14 QRAYGKQLLPGEGAAMASYVQEGK--RIPRRGEIGLSAEQIAAFERAGFVMSGSRHQRMNAVRVRKENQVISAEERQSEL 91 
EKC97552              367 eREAGKNLLPGEAAAMRQYVESGQ--RIPRRGEIGLDQNKIMQYEASGFVMSGSRNARMNAVRVRKETQVVNAEDKIDLM 444
EPB89730              260 ERAYGSQLLPGEGSAMAAYVKEGK--RIPRRGEIGLSGDQIAEFEKAGYVMSGSRHQRMNAVRLRKENQVISAEEKRLVL 337
EOQ99563              116 DKDFGREMLRGEGTAMAQFVQDGQ--RIPRRGEIGIESGEIDKLEQAGYVMSGNRHKRMNEVRVRKENEVYTAEEKRKMV 193
XP_006960508          171 ERDYGSDMLRGEGSAMAQYVQEGE--RIPRRGEIGLESNDIDKFEQAGYVMSGNRHKKMNEVRVRKENQVYSAEEKRKML 248
XP_016294096           29 PRAYGGALLPGEGSAMASYVQDGK--RIPRRGEIGLSSDQIEAYEKAGYVMSGSRHHRMNAVRMRKENQVISAEEKRTML 106
WGS:AAWC:PGTG_00913.3 291 PKEFGRALRPGEGSAMAAFIEAGE--RIPRRGEIGLTGTEIEKFENVGYVMSGSRHRRMNAVRIRKENQVISAEEKRGIL 368
KDE02558              331 rNAYGGALRPGEGTAMAQFVQDGA--RIPRRGEIGLESEQIEKFEQAGYVMSGSRHRRMNAVRVRKENQVISAEEKRGIL 408
CCA72846               39 EREYGGALLRGEGSAMAAFVQENA--RIPRRGEIGLSSNEIAAYENVGYVMSGSRHRRMNAVRMRKENQVISAEEKRSIL 116

XP_007396901          408 QLQKEERERREAILREEFQELVKD 431
XP_001731050           92 HQKRQDRARKEADIIAQFREMVDm 115
EKC97552              445 KTKKEEADRKEGEIISQFREMVEE 468
EPB89730              338 QHAQEQKIKRENEIISGFREILSD 361
EOQ99563              194 KEAAEDKMKRENEVVASFKELVSE 217
XP_006960508          249 KQSAEERLKKENEIVASFRELVSE 272
XP_016294096          107 RLQAEEKAKKEREIVSQFKELVDt 130
WGS:AAWC:PGTG_00913.3 369 KMQAEEKAKREGQIISSFRELVDT 392
KDE02558              409 QLQAQEKAKRENQIVSSFRELVDT 432
CCA72846              117 KLQKEEKQRREELLKAEFKELVEE 140
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