Conserved Protein Domain Family
PCIF1_WW

?
pfam12237: PCIF1_WW 
Phosphorylated CTD interacting factor 1 WW domain
This domain family is found in bacteria and eukaryotes, and is approximately 180 amino acids in length. This domain is the WW domain of PCIF1. PCIF1 interacts with phosphorylated RNA polymerase II carboxy-terminal domain (CTD). The WW domain of PCIF1 can directly and preferentially bind to the phosphorylated CTD compared to the unphosphorylated CTD. PCIF1 binds to the hyperphosphorylated RNAP II (RNAP IIO) in vitro and in vivo. Double immunofluorescence labeling in HeLa cells demonstrated that PCIF1 and endogenous RNAP IIO are co-localized in the cell nucleus. Thus, PCIF1 may play a role in mRNA synthesis by modulating RNAP IIO activity.
Statistics
?
PSSM-Id: 463502
Aligned: 27 rows
Threshold Bit Score: 180.543
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002293402    420 KLKTLFDtty----ksGSLTEIQSTHAFHTALFATVIRYSSLSGGqqlndWRGGGMQGAIHEGVFDCLGRWFGknAGTEC 495
EED96487        426 KLKSLYErti----lsVSGDLEEYHQYFPQTLFTILLRYDALEG---------AGLQSAIPPSVFHFLHKRFQ--CSWEC 490
jgi:OSTLU_16119 198 KLRALYCrtvrgceplTEDVDSDEYQKFACAVFALLMRYESLGG---------AGYQSALAEDAFDVLNEKLG--VSCEC 266
XP_003058243    245 KLRALYSrhslggaplPPE-GSSEHAAFAASVFALLARYDACGG---------AGYQAALGEKAFDVLKKRVG--VGCEA 312
jgi:OSTLU_27929 165 KLRALYEkhsraggddDGDDDVHD------RMFALLLRYKTIHG---------HGFQAACSHDVFRVLHDDLK--VTMEC 227
XP_002506891    326 salvnaaanvvdslndDASNEPKSYVVFHARLFALLLRYKSIHG---------YGFQASVGPEVFELLRRTVG--AQVEC 394
EEY67986        100 kLREMFAkkqg-lggdGSNMAPKDQQQLECALFCLLLRYESLDG---------GGFQAALNEECFDVLLKEFD--CKMEC 167
XP_002507705    203 KLRHLFAmrsesspplSSD----DISVFQSATFSMLCRYTAAQGGm---hRMSGGHHTALHAAVFDVLQHGLD--VEAEC 273
XP_001417960     40 KLKTLYAn-------aSSKEFVEN--DFLFDAFAMVCRYDAAAGGq---fRFSGGSQASLHGQVFDVLRDCFK--VECEL 105
Q4DIJ3          272 dvlitlevhaehvtrlrrlavcTEDGQFLFSLALVLLRYAGLSGGe---wQLESGWHAGVPHSVFDALVSAFR--VSVEC 346 Trypanosoma ...
XP_002293402    496 FASPFNCSLP------------QYFSAFp-----sPDLDGHFGSSGDFFhpSSnaaFLKS--GWYELNPPFSSGIMNNMA 556
EED96487        491 FASPFNCWLErrqgsgdivgggRFGCAF-------GDTDAWFGGAGSFFgmDFvsmANEQggGCFQANPPFASNFMESMC 563
jgi:OSTLU_16119 267 FASPLNARYG------------QFCSQFgfdedraPDVDAFFGSLGSFFsdDF---APKR--GSFEMNPPFVPETMSRAV 329
XP_003058243    313 FASPLNARYG------------RFCSAF-------PDVDGPFGSLGSFF--DF---APTR--GSFEMNPPFVPEVLLAAA 366
jgi:OSTLU_27929 228 FASPMNAYFA------------RFCSAF-------GDVDAPFGSIGSFA--AF---QPSR--GSYEVNPPFVREVLDEAA 281
XP_002506891    395 FASPLNAFHG------------RYHSAF-------PDVDGPFGSCGDFF--RYcadKIRR--GSFQVNPPFVSDVMSDAY 451
EEY67986        168 FASPLNCRYS------------RFCSAF-------LDTDFAFGSVGSFF--DF---SPRS--GCFEANPPFIPKVIKRMA 221
XP_002507705    274 FASPLNCHFH------------EYCSLF-------PDTDTTFGSRGSFF--SF---FPAE--GSFECNPPFEEGIVLRCA 327
XP_001417960    106 FASPLNCRWP------------MYYSKY-------GDVDKPFGSLGDFR--AC---KPSG--GAFEANPPFDEDVVARMA 159
Q4DIJ3          347 FASPLNCTLP------------RYFSAF-------PDTDVFFGCRGNFFalQHl-pPPEEglISLEANPPFDHEVIAAGL 406 Trypanosoma ...
XP_002293402    557 QRIEELLEMAtsrQ--L--DVTFIIVVP-TCRDHAT-----ASSASYHSK-KKAKKSEK--H 605
EED96487        564 NSMNKTLSQKdedDgnSgvPLMFVIFVP-AWRE--SsgwkaLTESPHLSK-HVVLLQKEdpH 621
jgi:OSTLU_16119 330 EKANDLLDRAanaN--E--ALSFVVIVP-LWKE--ChywsaLLESRHLQHgPDIIDAQS--H 382
XP_003058243    367 ERAEKLLRTAeesD--S--RLSFVVVVP-AWRD--VpmwtaLEKSAFKRGdALIVPASA--H 419
jgi:OSTLU_27929 282 LWCEALLERAeksQ--N--ALTFVFIMP-GWKE--TgafdaLTNSAFLRA-NVLIAAVD--H 333
XP_002506891    452 DAMATALNAAdeaD--S--PLTFVVFVP-GWTE--TsawrkLTASTHARN-SFVVAASD--H 503
EEY67986        222 DHMTALLNAA---D--G--PLAFIVIIP-AWQE--TegwqqLNASRFNQR-HLLIPQKQ--H 270
XP_002507705    328 EHVLLLLSRAeelK--T--ALSFAVITP-YWPG--RlawetVASSQYTSH-VERIRRNE--H 379
XP_001417960    160 EHLFECLDAA---S--S--ALTFVVVTP-HWPN--RpcwekMRRSKFCSR-AEVISVRE--H 208
Q4DIJ3          407 GRALQWLEDTpstT-----PLSFVFILPdSTQTNGIevrrkAEQSQFFRG-DCVLSPHM--S 460 Trypanosoma cruzi
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap