Conserved Protein Domain Family
Sulfotransfer_4

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pfam17784: Sulfotransfer_4 
Sulfotransferase domain
This family of proteins are distantly related to sulfotransferase enzymes. This protein in S. mansonii has been shown to be involved in resistance to oxamniquine and to have sulfotransferase activity.
Statistics
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PSSM-Id: 465504
Aligned: 218 rows
Threshold Bit Score: 107.339
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4Q4A6                  59 RLLVLTMIPNGGA-LGPALRMLGYHP-YTFEDSVRKGrllTHPQEWMAVMRGEKTfdfevlqapqhtasteavpsssgdp 136 Leish...
WP_015218936             7 KIFGIGLPRSGTSsLNQALSILGYKSlHHPTYYIMDK------------LNGSFS------------------------- 49  Cyano...
PEL:SAMY_003698        287 KVFGLGLSRTGTRsLTAALHVLGFDt-VHY------P---TDRATLDTLVRGDAR------------------------- 331
KKI98421               279 KVFGIGLSRTGTKsLTGALHTLGINt-IHYPDDE---------STLRELVEGNYE------------------------- 323
WP_055024750             3 KVFIIGLPRTGTTsVSVALLDYGFKv-AHIG------------------------------------------------- 32  Shewa...
WP_013052340             5 KVFIIGLPRTATTsLCVATLSLGFKT-AHT-------------------------------------------------- 33  Shewa...
WP_045963766             5 KFLVTGLPRTGTTsLCIAALGAGYKT-AHT-------------------------------------------------- 33  Pseud...
WP_010362942             3 KVFIVGLPRTGTTsVCVACLSLGYKT-AHT-------------------------------------------------- 31  Pseud...
PRJNA266250:OM33_07245   5 KIFVLGLPRTGTTsVCAAALELGFKt-AHTVY------------------------------------------------ 35 
KJZ00984                 3 KIFVIGLPRSGTTsVCAAALDLGLRT-AHT-------------------------------------------------- 31 
Q4Q4A6                 137 casrtpecatasttpSASPRAPLFFDSLVGPPAtvafeSILKECPRsTRVILVEEpDKLAWEKDMEQWLQPLVREckkSA 216 Leish...
WP_015218936            50 --------------------FEGDWDALTNFGEhf-ypQLDELYPN-SKFILTTR-DKEKWLNSCRWKYQEPS------- 99  Cyano...
PEL:SAMY_003698        332 ------------------FPLLDHYDGMTDITTapyfeDFDRLYPG-SKFVLTVR-DTPAWLQSCRNHWTGRSAYeeaST 391
KKI98421               324 ------------------FSLLQYLDGITDITVapfypQLDQLYAN-SKFILTIR-NKEEWLDALRNHWQDRP------A 377
WP_055024750            33 ----------------LTKRAFEVADVVSDVPCfcdypQLDKLFPD-AKFVYIDR-PLDKWVSSIQMLLTKMK------- 87  Shewa...
WP_013052340            34 ---------------AYTQRAMDEAQIIADTPVfcdyqQLDKAYPN-AKFVYLSR-ESDKWLPSIRQLLERMYTNlq--- 93  Shewa...
WP_045963766            34 ---------------AYTRQALDCAEFIADTPVfsdyeKLYALYPE-AKIIQLTR-EFEQWLPSIKRLMMAMKE------ 90  Pseud...
WP_010362942            32 ---------------AYTRNTFREAQVIADTPIfndykQLSVLYPD-AKYIYLDR-ELSLWLPSIAQLLTRMSS------ 88  Pseud...
PRJNA266250:OM33_07245  36 -----------------IQETLEAAEFIADTPVfhdydTLLARFPN-AKFIYLER-DLANWLPSIKVLLSRMAe---rLL 93 
KJZ00984                32 ---------------AYTKACFERAELIADTPCfshylELAERFPE-AKFVLLQR-QPERWLESIQRLLQRMKTN----- 89 
Q4Q4A6                 217 IWWnASKLHmMLLDMVDLRRALISPNNQR-G-G-RArpspssfaamtaqnvpismqHTTLRLSGALDLFEEHVKEVVP-- 291 Leish...
WP_015218936           100 ------------NNLGNAIR---ISIFGC-D----R--------------------FHESTYSYIYDQHTRNVIEYFKnr 139 Cyano...
PEL:SAMY_003698        392 ----SDPIAaEEHRVHMEIRRFLRAAVYA-S-Y--E--------------------FDEARFERAYRRHVENVTRYFAdr 443
KKI98421               378 FAD-ANAKRdIHMHIRRLLRSAVYGCYE----------------------------FSYDRLSYVYDLHYETVLRYFQnr 428
WP_055024750            88 -----PNLLeKTGTFHPILKRSFKQTFGDiNaD-NL--------------------LDEARLKACYLRHQQGVLNYFAq- 140 Shewa...
WP_013052340            94 ---------rSDGGFNPILKRCYNDIFAP-LtLdNI--------------------AKDSFLLACYQRHYQGALDYFTgr 143 Shewa...
WP_045963766            91 ------NLLsQRGGFNDTIKRCYLETFPD-FyK-HF--------------------EDDGYWQDCYSKHHERVLRFAK-- 140 Pseud...
WP_010362942            89 -NL-FSEKGgFNDTIKRCYLETFSGLTAD-----NT--------------------DDYAFLTQCYEAHKHTALDFFK-- 139 Pseud...
PRJNA266250:OM33_07245  94 TE-----HGgFFPSLKRCYGEVFYPLTTE-----SM--------------------LDDNHLTARYFAHRDAVLAFFEri 143
KJZ00984                90 --L-LSD----TGGFSPLLKASYHRVFSPlNeQ-SL--------------------VDGKHLEYCYKRHQQQVSTYFAqq 141
Q4Q4A6                 292 RDR----L--LVYRVR--D--GWQPLCDFLQVPV--P------MApataggappepvAFPPNSTGSDI 341 Leishmania major
WP_015218936           140 PND----L--LVVDWGlgH--GWKELCYFLNKPV--P------Et------------PFPNKNSKQEI 179 Cyanobacterium ap...
PEL:SAMY_003698        444 PDD----L--LVLDIArgD--GYEKLAPFLGVPV--P------EQ------------PFPHKGK--RL 481
KKI98421               429 PGQ----L--LVINIC--EgeGWEKICPFLGKPL--V------QH------------PFPFVKKQSLI 468
WP_055024750           141 RDD----L--LTITLS--EpdSLTQLLRFIGVSE--NrinaslNh------------SFPVLNVGTHV 186 Shewanella sp. P1...
WP_013052340           144 EQD----L--LIIDVA--HtdSFQQLADFLDVTAlqP------SQ------------NFERINIGGKV 185 Shewanella violacea
WP_045963766           141 MNDipfiM--VNLTAA--D--AEQTLAEFIGETQ--E------Kv------------IIPHVNIGGKV 182 Pseudoalteromonas
WP_010362942           140 AQR----LshLVLNLT--KpdAMQQLAAFLGVNS--G------A-------------KMPFLNKKGKV 180 Pseudoalteromonas...
PRJNA266250:OM33_07245 144 DNP----R--LIINLS--DpqSYQHFCHFLEKA---P------KG------------GFEQLNVNGKV 182
KJZ00984               142 AHR----L--LTIDIS--EphSFQQFCQFVGTNS--T------SK------------QFAHLNQHNKV 181
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