Conserved Protein Domain Family
DUF6594

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pfam20237: DUF6594 
Family of unknown function (DUF6594)
This entry represents a group of uncharacterized proteins that contain a set of C-terminal transmembrane helices. The family may be related to pfam10267.
Statistics
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PSSM-Id: 466388
Aligned: 216 rows
Threshold Bit Score: 51.2088
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_018063207  38 WPSLAKTVADTR-G--FAAFPSFTDLNVKSL----LYYQAQ-LIRLRKELhkTEFE--DY--FHGADPERNFad---dlD 102
XP_016644964  25 YTALASFLGSYP-E--VLAIRRFRELQIRNL----LFYQAE-LAHLEAEL--QEIE--NQdaQRKYDPSDRAn-----fR 87 
EPS38119      73 YSKLAAFIDL---EddLAIFRRFSRLHAQLL----LYRQAD-IEEVEEELl--ELD--RIeaEAARIEGTPAntl--nrS 138
EGX49335      50 YSYIAAYADGHE-V--APVFRRFGALKARVL----YTQQAE-LEEKEETL--ARIDlqESlnANPVWDT-DNm------R 112
EPS45661      40 YSRIAAYVDGHEdA---PIFRRFGLLKARVL----LTQQAE-LEEKENDLr--RID--EReaEVSRQRQETPdn----vT 103
OJJ41949      10 YNLFSSLVNS---DteLNVFRAFKELNTRNI----LYLQSE-LAELEETF--HDLD--ELynDKTKGNDTWSip----rS 73 
XP_013276463  14 YPELAI-------------FRRFGHLSAKVL----LYAFALqMNEVSKIR---SPE------------------------ 49 
XP_018000041   7 YDRLALLFSKHP-E--LANFRCFRHATLKCL----LYKQAE-LTYLETQ----ANA--SAvlNRAAGGDEKLttsyqyfA 72 
XP_016238700   4 YGALASMMASHQ-S--AEAFRKFSSMNLENI----LHMQAE-LQHLE--L---IIN--EIrkIPELNSFDR--------T 60 
XP_018381456   8 YSKLYGDFVQDP-E--LAKFRRYLDYWSWMLynenWEIEQK-IRECN------EIVa-NIhsVPPTRSVYTLmdy--pqT 74 
XP_018063207 103 WMFDVDdsrqsgpeqknseqteseekgsgqddseqqdsdeedsqhrsleQLRIl------EK-IRTILDK-YnN-ALIQF 173
XP_016644964  88 WTPCMVrekpaktrapdcag----------------gcqkpedpspptsRETMnssylekVLqIRRTLSS-Y----MEQY 146
EPS38119     139 WRREKDle---------------------------------------eyRVQL-------VKqLRKHLKA-YdD-ELFRY 170
EGX49335     113 WLEDRNk-----------------------------------------kRTDLi------AD-IAKRLRR-YeK-DLILY 142
EPS45661     104 WLRDKNn-----------------------------------------tRKDL-------VEdIAKRLRR-Y-EkDMLLY 133
OJJ41949      74 WYAMNKeg---------------------------------------grYLDT-------VTrMRRVSEGyY---KALQT 104
XP_013276463  50 -------------------------------------------------PRNL-------ES-LRKWLAS---E---EGG 66 
XP_018000041  73 YDAQGSea---------------------------------------ddQREAm------KE-LEEKLGS-YhE-MLKSA 104
XP_016238700  61 WIESPEhms-------------------------------------eddVRNIf------ER-SRTLLNQ-YhR-TLLQT 94 
XP_018381456  75 YVKKQDpt----------------------------------------lESKI-------ED-LKKLIRR-Y-G-KDLTL 103
XP_018063207 174 SQ--VsA-FPDADSSNVDCLRkfarkvcdptaiigtgsqtwgtlraekgtsgtretfwplfwglfVGFFKTQEvkrdpvk 250
XP_016644964 147 KR--LsA-LPNPKRRDMAAIHew-----------------------------------------lNDMSLGTAflagdve 182
EPS38119     171 KTk---LgLRDATNWQIKNMKtwmn------------------------------------nqrpHPLVPTES------- 204
EGX49335     143 RQ--IrQ-FPNAKKWQKENFRaml--------------------------------------rnkEPICEEES------- 174
EPS45661     134 RQmlL---LPSAQKRQIINFEnil---------------------------------------hnDPLDRMES------- 164
OJJ41949     105 QSwlLd--QKPPSSRAYRALRgmfd-------------------------------------ahkPHMSRLDA------- 138
XP_013276463  67 NH--F---LAQAGVEAKAw--------------------------------------------------DAESs------ 85 
XP_018000041 105 SD--VfR-LEKTSRKSLQTLRdw-----------------------------------------lGRDDGGQS------- 133
XP_016238700  95 AK--InA-MHAPQKDDLDLRRkw-----------------------------------------yDEESGGNHflygvea 130
XP_018381456 104 AHa--iAnLPSQPEIWARHFSeyteaf---------------------------------qdgrfGPTNEDAT------- 141
XP_018063207 251 nEFq---------------eHLIV---PrvgsKPD---------GLT---TW------VTYS---FIPLFHH-------- 283
XP_016644964 183 dVWtvelgd-----gkskaaDVSDfygF----EDQggla-fpigSAV---AW------LHRL---FFRSNGSas------ 234
EPS38119     205 -KFled------------igDVCT---L----KAGsedsavltdFLR---SF------ARDScgcLSWMFRKkgnp---- 251
EGX49335     175 -GFie-------------kgDLVS---Im--kEVDdv------sELS---EW------ISDI---RRSTFNN-------- 209
EPS45661     165 -RFldd------------rdDLIA---L----HKEse------dSIE---LWepvsdlLNDI---FDIFWLKifkqespr 212
OJJ41949     139 -SFiled---------ahrdDLIA---L----LVKek------eALS---RF------LAKY---LYRLFEEkritn--h 181
XP_013276463  86 -------------------eDLMA---F-----RYld------dRFA---QW------IMNV---VIPAYHR-------- 112
XP_018000041 134 -FFkdnmlesdpwtmpanehDLIV---L----DNKea------dGFA---DL------VTDH---VLAVWHYvvgrh--l 185
XP_016238700 131 gIFrdet----------ietDFMT---L----KENles----qdALA---RF------LGRR---IVPLYHRtvghr--i 175
XP_018381456 142 -VYsqvp----------shaDTCS---L----KASevdq--qdhLTSfaiRH------LKSInirLRKWIARgsker--s 193
XP_018063207 284 ---VWQGWgsptwaglwtrvtgpfsschlpkcwqdaspptdiaasrgetepkdeknlagvTAYSKSWIFRV-TSILTT-I 358
XP_016644964 235 ----------------------------------------------------------rqPHHVDTSVYGAlDQAITT-V 255
EPS38119     252 asyGDPTI----------------------------------------------------TYYNTEWKDAL-TRIAYAtL 278
EGX49335     210 ---FGLKEllfrkkeka-----------------------------------vyegsdeiILYSSKLMRIV-GRTFFG-A 249
EPS45661     213 ayqGSREI----------------------------------------------------TVLAKQWMQAI--SRLMYgI 238
OJJ41949     182 sgeL--------------------------------------------------------SIISDERIQLF-VRVSMI-I 203
XP_013276463 113 ---RIGHWihqkrer---------------------------------------ddlgdlWHYKEGPFMVI-GDILCT-F 148
XP_018000041 186 shaEEDPNlg------------------------------------------------kiWRYERATLTMI-GNIICM-L 215
XP_016238700 176 hrtMEEKAfe------------------------------------------------qtCYYTPETLVRI-GNTICM-L 205
XP_018381456 194 eeeGAAPE----------------------------------------------------QFVGLEKIVMV--ANVFAgI 219
XP_018063207 359 VACLLPVIAIVVL--SrvHSMGMILGLIALFNSIFAFGLVLISTG-SSrVDIFTATAAFSAVMV 419
XP_016644964 256 VASVLPVLPIVVL--YfvKDMLVRIGLILVFTVVFSAILVVGLQI--KpHATLAITTAIAAVQV 315
EPS38119     279 VSAILIAGVIVLF--Yi-ESPGGRLACLCVSTFLCGLVMALFTTA-KK-GEIMGATAAYCAVMV 337
EGX49335     250 LVGVVVTSGVVLL--YyvKVDEWRLLVLGMSTLVCAILTAVFTTA-KK-GEVFAVAAAYCAVLV 309
EPS45661     239 IVTAIVTFGVILL--YfvKTDSWRLVILCCATLLCAVLTSILTKA-KK-SEVFGVAAAYCAVLV 298
OJJ41949     204 LSSVLPILSIIVL--YvvKSQSIRLGLVVVFSALCSAALATMSGA-RN-AEIMGVTAAYAAVQV 263
XP_013276463 149 LSSLRPSCCIFVL--YtvQKALTRFVLITCLSLAFSLVMTFVVQA--RrQDVFAATTALAAVQV 208
XP_018000041 216 FSFIIPTVSIFVLdnI--TTMRNRLIFVSVFIFLFAFTMMFVVGI-RR-DQVFAATAAFAAIQV 275
XP_016238700 206 LSAIIPALSIMVL--FsvQSIGGRLIAISMMSLIFSLVMNVIAQR--R-ADVFMSTTAFAAVLV 264
XP_018381456 220 YVPVFFAACLGVLssI--QSEKWRIVVLGAFGLMLTALLILCVPTlKR-SDMFAITGAFFAVGG 280
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