Conserved Protein Domain Family
OSTEO

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smart00017: OSTEO 
Osteopontin
Osteopontin is an acidic phosphorylated glycoprotein of about 40 Kd which is abundant in the mineral matrix of bones and which binds tightly to hydroxyapatite. It is suggested that osteopontin might function as a cell attachment factor and could play a key role in the adhesion of osteoclasts to the mineral matrix of bone
Statistics
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PSSM-Id: 214472
Aligned: 8 rows
Threshold Bit Score: 189.047
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001035147  17 IPVK----QADSGSSEEK------QLYNKYPDAVATWLNPDPSQKQNLLAP--QNAVSSEETNDF-KQETLPSKSNESHD 83  human
P31098        17 LPVK----PTSSGSSEEK------QLNNKYPDAVATWLKPDPSQKQTFLAP--QNSVSSEETDDN-KQNTLPSKSNEDPE 83  cattle
NP_999188     17 LPVK----QTNSGSSEEK------LLSNKYTDAVATLLKPDPSQKQTFLAP--QNTISSEETDDF-KQETLPSKSNESPE 83  pig
NP_776612     17 LPVK----PTSSGSSEEK------QLNNKYPDAVAIWLKPDPSQKQTFLTP--QNSVSSEETDDN-KQNTLPSKSNESPE 83  cattle
P31097        17 LPVK----HADSGSSEEK------QLYHKHPDALATWLNPDPSQKQNLLTP--QNAMSSEEKDDL-KQETLPSKSIESHD 83  rabbit
NP_001191130  33 LPVK----VTDSGSSEEK------KLYSLHPDPIATWLVPDPSQKQNLLAP--QNAVSSEEKDDF-KQETLPSNSNESHD 99  house mouse
NP_037013     17 LPVK----VAEFGSSEEK------AHYSKHSDAVATWLKPDPSQKQNLLAP--QNSVSSEETDDF-KQETLPSNSNESHD 83  Norway rat
P23498        17 WPVSksrqHAISASSEEKydprshHTHRYHQDHVDSQSQEHLQQTQNDLASlqQTHYSSEENADVpEQPDFPDIPSKSQE 96  chicken
NP_001035147  84 HMDDMDDEDdDDHVDSQ-DSIDSNDSDDVDDtddsHQSDESHHSDESDelVTDFPTDLPATEVFTPVVPTVDTYDGRGDS 162 human
P31098        84 QTDDLDDDD-DNSQDVN-SNDSDDAETTDDP----DHSDESHHSDESH--QVHFPTDIPTIAVFTPFIPTESANDGRGDR 155 cattle
NP_999188     84 QTDDVDDDDdEDHVDSR-DTDSEEADHADDA----DRSDESHHSDESDelVTDFPTDTPATDV-TPAVPTGDPNDGRGDS 157 pig
NP_776612     84 QTDDLDDDD-DNSQDVN-SNDSDDAETTDDP----DHSDESHHSDESD--EVDFPTDIPTIAVFTPFIPTESANDGRGDS 155 cattle
P31097        84 HMDDIDEDEdDDHVDNRdSNESDDADHPDDS----HHSDESHQSDESDe-VTVYPTEDAATTVFTEVVPTVETYDGRGDS 158 rabbit
NP_001191130 100 H------MDdDDDDDDD-DGDHAESEDSVDS----DESDESHHSDESD--ETV--TASTQADTFTPIVPTVDVPNGRGDS 164 house mouse
NP_037013     84 H-------MdDDDDDDD-DGDHAESEDSVNS----DESDESHHSDESD----ESFTASTQADVLTPIAPTVDVPDGRGDS 147 Norway rat
P23498        97 AVDD-DDDDd---------NDSN------DT----DESDE----VVTD-----FPTEAP----VTPFNRG-D-NAGRGDS 141 chicken
NP_001035147 163 VVYGL-RSKSKKFRRPDIQYPD--ATDEDITSHMESEelngaykaipvaqdlnapsdwdsRGKDSYETSQLDDQSAETHS 239 human
P31098       156 CGLRT-EVKIIEVPPINVQSPD--ATEEDFTSHIESE-----------------------RCMSTKKTSRLTDHSKETNR 209 cattle
NP_999188    158 VVYGL-RSKSKKFRRSEAQQLD--ATEEDLTSHVESEetdgtpkailvaqrlhvasdldsQEKDSQETSQPDDRSVETRS 234 pig
NP_776612    156 VAYGL-KSRSKKFRRSNVQSPD--ATEEDFTSHIESEemhd----------------------apkKTSQLTDHSKETNS 210 cattle
P31097       159 VAYRLkRSKSKMFHVSNAQYPG--ASEEDLSSHVDSEdlddtpraipvaqhlnvpsdwdsQEKDSHDVSQVDDHSVETQS 236 rabbit
NP_001191130 165 LAYGL-RSKSRSFQVSDEQYPD--ATDEDLTSHMKSGeskesldvipvaqllsmpsdqdnNGKGSHESSQLDEPSLETHR 241 house mouse
NP_037013    148 LAYGL-RSKSRSFPVSDEQYPD--ATDEDLTSRMKSQesdeaikvipvaqrlsvpsdqdsNGKTSHESSQLDEPSVETHS 224 Norway rat
P23498       142 VAYGF-RAKAHVVKASKLRKAArkLIEDDATAEVGDSq---------------------lAGLWLPKESREQD-SRELAQ 198 chicken
NP_001035147 240 HKQSRLY-------------------KRKANDeSNEHSDVIDSQELSKVSrefhsHEFHSHEDMLVVDPKSKEEdKHLKF 300 human
P31098       210 CELSKEL-------------------MPKAKD-KNKHSNLIESQENSKLS-----QEFHSLEDKLDLDHKSEED-KHLKI 263 cattle
NP_999188    235 QEQSKEY-------------------TIKTYDgSNEHSNVIESQENPKVS-----QEFHSHEDKLVPDSKSEED-KHLKL 289 pig
NP_776612    211 SELSKEL-------------------TPKAKD-KNKHSNLIESQENSKLS-----QEFHSLEDKLDLDHKSEED-KHLKI 264 cattle
P31097       237 HEQARQY-------------------KREANDnSVEHSHSIDSQESSKVSqesqsREFRSHEDKLAIEPKSEEDeEHRQL 297 rabbit
NP_001191130 242 LEHSKE-----------------------SQE-SADQSDVIDSQASSKASlehqsHKFHSHKDKLVLDPKSKEDdRYLKF 297 house mouse
NP_037013    225 LEQSKEYkqrashesteqsdaidsaeKPDAID-SAERSDAIDSQASSKASlehqsHEFHSHEDKLVLDPKSKEDdRYLKF 303 Norway rat
P23498       199 HQSVEND-------------------SRPRFD--SPEVGGGDSKASAGVDs----RESLASRSAVDTSNQTLESaEDAED 253 chicken
NP_001035147 301 RISHELDSASSEVN 314 human
P31098       264 RISHELDSASSEVN 277 cattle
NP_999188    290 RVSHELESASSEIN 303 pig
NP_776612    265 RISHELDSASSEVN 278 cattle
P31097       298 RVSHELDSTSSEIN 311 rabbit
NP_001191130 298 RISHELESSSSEVN 311 house mouse
NP_037013    304 RISHELESSSSEVN 317 Norway rat
P23498       254 RHSIENNEVTR--- 264 chicken
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