Conserved Protein Domain Family
IFTAP

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pfam17722: IFTAP 
Intraflagellar transport-associated protein
Intraflagellar transport-associated protein (IFTAP, C11ORF74) interacts with the IFT-A complex and is accumulated at the distal tip in the absence of an IFT-A subunit IFT139. In IFTAP-knockout (KO) cells, the BBSome components cannot enter cilia. However, IFTAP-KO mice demonstrated no obvious anatomical abnormalities associated with ciliary dysfunctions.
Statistics
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PSSM-Id: 465470
Aligned: 12 rows
Threshold Bit Score: 297.833
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003781594   1 MPAPVS-GLERMDKDRLIEEVLDRFVNCHEQTYEEFLSTFTHLSKEYDVTKsGAF-GSDSSEKIFTSRKSTHKNEPNDHH 78 
XP_013215071   1 MPSQKS-GLEIMDEDQLMEEVLDKFVNCHEQTYEEFRSTFTHLSKEDNVTKrGAL-GTDASGKIFTSVKFTHKNEPNDHH 78 
XP_005001023   1 MPSKIL-GLEIMDKDPLMEEVLDKFINSHEQTYEEFLSTFTHLSKEDIMTKrGAL-GLAAS-NTFMSVEFTHKNEPHDHC 77 
XP_014320828   1 MPAKIP-ELETMDEDQIIKEVLDKFVNCHEQTYEEFLSTFTHLSKEDKVTQrGLF-GTRSSEDIFISVQLTHENEPNDHR 78 
XP_001488034   1 MPSQIS-ELQIMDEDGLIEEVLDKFVNCHEQTYEEFLSTFPHLSKEDNVTKrEAF-GTDSSENILTSIKFPHENEPNDHH 78 
XP_004756061   1 MPAQIS-DLEIMDEDQLIEEVLDKFVNCHEQTYEEFLSTFTHLSKEDNVTKrGAF-GTDSSENVFPSVKFAHENEPNDHH 78 
XP_008268048   1 MPAQTS-DLKIMDEDRVIEEVLDKFVNSHEQTYEEFLSTFTYLSKEDNGITrGAF-GTSSSEKLPS-VKCTHENEPNDHH 77 
XP_007497398   1 MSLQLL-ELRIMDENQLIEQVLDQFIHRHEQTYEEFLNTFTYLSKD------HKS-STDSSRDIFSTVLFPHDQPIRNEH 72 
XP_014343651   1 MPIVLS--TSCNMEEGLIQDALDRFCSSHEQTYAEFLNTFTHLTKEDVEKKrGPT-GAVESADEVSSGNTSMAAVGSAGQ 77 
NP_001273177   1 MGEQLV-----------NNCILDQFINSHEQSYEEFLSTFTYLLKEDERKTiQG--RKKSLRKSFSASEISNGNKQDGLP 67 
XP_019332751  23 GYDCLTvRVVIMEKQPL-NSILDQFINSHEQTYEEFLGTFTYLLKDEVEKKsQES-EVDSLEKTFSVLELPNRNKESVLP 100
EDL79620       1 MPAQIPrRPEIMSEDQLMKEVLDKFVNCHEQTYEEFLSTFTHLSKEDNVAK-GGAhGMNLSENTLTAEKWNHKIESNGHH 79  Norway rat
XP_003781594  79 -V------RN---KTIFLHTSS-QC--SE--E------------------------EQIDNFLDLEDLDVDEELQPQTCK 119
XP_013215071  79 -L------RN---TTVFHQTSS-QC--SE--EeqivmdegqkvgsflqgdlnragkIKVDNFLDLEDFDMDEEIEPQMSK 143
XP_005001023  78 -L------GH---TSTSLRTSS-QC--LE--EeqivldegqkvgnffqgdlnragrVKVDNFLDLEDLDAD-EDTPQMSR 141
XP_014320828  79 -L------RS---KAIFFRTSS-QS--SG--EeqivldegqqvgisfqgdpnwagkVKVDNFLEVEDLDMDEEIKPQMSK 143
XP_001488034  79 -L------RN---KAIFLRTLP-QC--SE--EeqivmdegqkvgssfqgdlsragkVKVDNFLDLEDLDTDEEIRPQMPT 143
XP_004756061  79 -L------RN---KAVFLHTSS-QC--SE--DeqividegqkvgssfqgdlnragkVKVDNFLDLEDLDVDEETQPQMSK 143
XP_008268048  78 hL------GS---KTIFLRTSS-QC--LE--Eqivveegqkvvs-flqgdlnragkVKVDPLLDLEDLDVDEEIKPRMSK 142
XP_007497398  73 -LpvgpvaPQpeeEEVIPWASPfVCglSQdhEpeividegqkvgissqgdlhragkVKVDNFLDLEDFDRDEETGHKQSP 151
XP_014343651  78 -------------STALL--PA-QN--SE--DeqlvleeglktgsfkegdlhllgkIKVDNYMDCEDVESDEDVALESLR 137
NP_001273177  68 -E------RS---KEKLVSFPP-QT--PN--EnktvineswksggsdgnglslserAQVDHHL---ETDIDGEPHSA--- 126
XP_019332751 101 -A------RS---KESSVSLSS-QP--LE--EdqvvmseglkvgfskncdlslarrVKVDNYLALEDFDTDEESGQEKCI 165
EDL79620      80 -F------RN---RTIFLHDSS-EC--SE--EdqividegqkvgssfqgdmtragkVKVDNFLDLEDVDTEEESKPQMNK 144 Norway rat
XP_003781594 120 -EMLLLPGEAEQSISPCISSYHPSV-----D-RRLTGEVKPESTGKGAA------RQMEE--V-PGDEVQPFSLDEEFDY 183
XP_013215071 144 -DFLLLPGQVEEDVSTSVCSFIPSV-----D-KPLAAEGKPKPTVKRTE------KQAEE--I-FGDEVQPFSLDEEFDY 207
XP_005001023 142 -DLLLLPGEADEDISSTVPSYLPSV-----H-QPLTAEVKPKPTIKGKE-------PNEE--V-LGDEVQPFSLDEDFDY 204
XP_014320828 144 aDLPLLPGEVE-DVSTHIPSGIPPAadippAaQPLTPAVVPRPTVERAD------RQKDE--I-LGDEVQPFILDEEFDY 213
XP_001488034 144 -DLLLLPGEVEPDASASAPSHVPSV-----A-QPLPPGGKPTPARKGAD------KQREE--M-LGDEVQPFSLDEEFDY 207
XP_004756061 144 -DLLLLPGEVEEDFYPRVPSYIPSV-----A-QPFAPGVKPGPAGRGAD------KQTEE--T-LGDEVQPFSLDEEFDY 207
XP_008268048 143 -DLLLLPGEVEQDVQA----SVPSM-----D-QPLSPHVKPRPTVKGTDveeiprAEVQSssLdEGDEVQTFCLDEEFDY 211
XP_007497398 152 -ELMLLPGEVEDEAHFSVSSYVPSF-----D-QHSCPEPKTQPAEQPAY------RHLKE--V-SGDEVQPFSLDEEFDY 215
XP_014343651 138 -GAGLLPGETEHEVPL----YTPSV-----L-QHTQLSLRTDSGARQPQ------EEPET--V-RTDEVQPFSLDEGFDY 197
NP_001273177 127 -GSFVLPGEVEEIGTC----CTPPL-----E-KPVQRKLKTSSVQQPLD------NKAEE--L-LGDDVQPFLLDEEFDY 186
XP_019332751 166 -GSLVLPGEVEQTVAG----YTPYF-----D-HTIHLKVKVLPVTQPSN------NKTQEfqL-LGDEVYPFSLDEDFDY 227
EDL79620     145 -DWMALPGEVEQGISISAPAYVPAV-----G-LPLTSEGKPTPAVGRTQ------TQTEE--I-LGDEVQPFFLDEDFDY 208 Norway rat
XP_003781594 184 DSVVLTPKFSLAEIETLKE-LSA-RKRKD 210
XP_013215071 208 DNVALTPKFTAAEMETIRE-LLK-QERKN 234
XP_005001023 205 DNVTLTPKFTSAEIETMKL-LLK-QERNN 231
XP_014320828 214 DTVMLTPKFTPAEVEAIKEqLSK-HKREN 241
XP_001488034 208 DAVTLTPKFTPAEMDAIKE-LSA-RKGEN 234
XP_004756061 208 DAVMLTPKFTPAEIDAITQ-LSK-QERSP 234
XP_008268048 212 DSVTLTPKFTPAEIESIKE-LSK-QRTEN 238
XP_007497398 216 DTVTLTPKFSNAEMKTILE-MSS-RSRLN 242
XP_014343651 198 DNVPFSLKYSRAELALLKG-PPGgRGTSV 225
NP_001273177 187 DNVALTPKFSEAELMPMKE-LSE-EKKRG 213
XP_019332751 228 DNVALTPKFSEAEMKSMID-LSE-QKKRR 254
EDL79620     209 DNVTLTPKFTAGEIATIQE-LAK-QKRVD 235 Norway rat
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