Conserved Protein Domain Family
bHLH_TS_dAS-C_like
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cd19744: bHLH_TS_dAS-C_like 
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins and similar proteins
Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.
Links
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Statistics
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PSSM-Id: 381587
Aligned: 6 rows
Threshold Bit Score: 76.8601
Created: 6-Aug-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      #   # ### #    #                                    ####                  
P09774     84 SVARRNARERNRVKQVNNGFVNLRQHLPQtvvnsls---------nggrgssKKLSKVDTLRIAVEYIRGLQDML 149 fruit fly
P10083     25 SVIRRNARERNRVKQVNNGFSQLRQHIPAaviadlsng-----rrgigpganKKLSKVSTLKMAVEYIRRLQKVL 94  fruit fly
EFX72751   82 SVARRNARERNRVKQVNMGFAVLRQHIPTsfceastasdsgrsssgggssksRKVSKVDTLRCAVEYIRSLQEML 156 common water flea
P10084    100 SVQRRNARERNRVKQVNNSFARLRQHIPQsiitdltk--------gggrgphKKISKVDTLRIAVEYIRRLQDLV 166 fruit fly
P09775    160 AVARRNARERNRVKQVNNGFALLREKIPEevseafea-------qgagrgasKKLSKVETLRMAVEYIRSLEKLL 227 fruit fly
KRY38273   28 QVARRNARERNRVRQVNMGFVILRDHIPHyg-------------------knKKLSKVETLRAAANYIQHLQNLL 83  Trichinella spiralis

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