5U0S,5OQM,6XP5


Conserved Protein Domain Family
Med14

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pfam08638: Med14 
Mediator complex subunit MED14
Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.
Statistics
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PSSM-Id: 462543
Aligned: 129 rows
Threshold Bit Score: 109.511
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5U0S_N         13 FYPLPEIVETFSHHVLQELVSLAEVLPSMS----NVEKKKKILDWLLRSRAFTMRLLVLARW--VHLSPSVHRCIDVVAF 86   fission yeast
Q03570        104 TIPLNVLLDFAIQHVYHEITVLAELMQRKTndqgEQERKMSLVHFAHATRSQFLKLVALVKW--IRISKRMDVCYSIDYL 181  Caenorhabditi...
ESN95203       19 VVPLSTLMEFLIQRTYHELSILSELLLGKN----DLERKIEICQFANRTKQTFVRLLALVKW--TNSANKVDKCARIFSF 92  
XP_002932839   38 GYRLSTLIEFLLQRTYQELNVLADLLPRKS----DMERKIEIVQFASRTRQLFVRLLALVKW--ANNAGKVEKCAMISNF 111 
EEN49348       15 SISLGMLVDFIIQRTYHDLTVLSELLPRKT----DMERKIAIVQFAHRTRQLFVRLLALVKW--ANSAAKVDKCAMISAF 88  
XP_003244766   22 SLSLSVLIDFIVQRTYHELTVLAELLPRKP----DMERKIEIYKFSNRTRQLFVRLLALVKW--ANSASKVDKSTQIMGF 95  
EDW30113       30 TMSMSMLIDFIIQRTYHELTVLAELLPRKT----DMERKIEIYNYAARTRHLFTRLNALVKW--GNSVSKVDKSSQIMSF 103 
XP_015794906   18 TMSLSRLVDFTVQRTYHELLILTDLLPQKS----DIERKIEIISFANRTRQLFIRLLALVKW--AGSASKVEKCSTIVAF 91  
EDO35223       10 KINLSMLIDFLLQKTYHELTVLSELLPRKP----DIERKIEIVQFASRTRQQFVRLLALVKW--AGGAKGVAKCQAISTF 83  
CBJ25901       20 TLLASELCLRQTDRAFHDIRRLANILSRVN----HDSRREDLLDYIRSNRARFLKAYAIISWlsGNHGELVANASNALAE 95  
5U0S_N         87 LQGQKFCFQNLVHVL-QDIRYQLSFARLRNSDLVTALDILSTGTSLRLanaPTSKly---mlSESPL--STKQILQTLHA 160  fission yeast
Q03570        182 LDLQSQYFIDTADRLvAMTRGDLELARLPEYHIAPAIDVLVLGTYNRM---PSKIkea--fiPPAKI--TPREQKLVTSR 254  Caenorhabditi...
ESN95203       93 LQQQQLLFVETADCLaRMARETLVHARLPSFSLPCAIDVLMTGTYPRL---PFCIkek--ivPPEPL--PPLEKKRVLTK 165 
XP_002932839  112 LDQQTILFVDTADRLaSLARDALVHARLPSFAIPYAIDVLTTGSYPRL---PTCIrdk--iiPPDPI--TKNEKQTTLHQ 184 
EEN49348       89 LDQQAMIFVDTADMLyRMVRE-LVHARLPSFNIPHAVDVLTTGTYPRL---PKCIrdr--ivPPDPI--TPAERKATLLR 160 
XP_003244766   96 LDKQSLLFIDTADMLsRVARETVVSARLPNFHIPSAVEVLTTGTFSRL---PACIrer--ivPPDKI--TPAEKRETLLQ 168 
EDW30113      104 LDKQNMLFVETADMLaRMSRETLVRARLPNFHIPAAVEVLTTGTYNRL---PTCIrer--ivPADAI--TPAEKKQTLLR 176 
XP_015794906   92 LNKQAMFFIETADSLaKMARENLVQARLPALQLPAAVEVLTLGSYTRL---PTCIrdr--ivPPDSI--TPAEKKATLQR 164 
EDO35223       84 LDQQSMVFVDTADMLaRMARETLVQARLPTFCLPAAVDVLTTGTYQRL---PTCIrdk--ivPPDPL--SLSEKNKTLQR 156 
CBJ25901       96 ARSQREQIDACQDQF-FFMHGGLFGARQRLYDVPVAVDVLIGGRYPHL---PKGIeycggdiDPRPIfeLPANREEIVLR 171 
5U0S_N        161 LNMLIRIRLSl-YEIIPTPFQHFTIANGRCTFTVPNEFSVSLTTNS 205  fission yeast
Q03570        255 LNQLIESRLSrlSSGIPPNIKEIHINNGLATLLVPGEFEIKITLLG 300  Caenorhabditis elegans
ESN95203      166 LTQVIEYRIV--MNDLPHSMCKPVIENGRVKFTVDHEFEVFLTLMG 209 
XP_002932839  185 LNQILRHRLV--TTDLPPQLANLTVANGRVKFRVEGEFEATLTVMG 228 
EEN49348      161 LNQIIQHRLV--TTDLPPQLGNLTIANGRVKFQVSHEFEATLTLMG 204 
XP_003244766  169 LNRVIQHRMV--CSNLINEMSCKKVANGRVTFRVENEFQVSLTLMG 212 
EDW30113      177 LNQVIQHRLV--TGKLLPQMREFRIKNGRVTFEVKHEFSVALTVMG 220 
XP_015794906  165 LNQIIQQRLV--ISNLSPQMKNFKIDHGRVIFHVNHEFEMALTLMG 208 
EDO35223      157 LNEVIQHRLV--LARIPPQMASLKIADGCVTFHVDNEFEVSLTLMG 200 
CBJ25901      172 VDRAIRLALLr-RGGVPNQFTSHTVKNGVLTLTVNGEFELMVTLQA 216 
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