Conserved Protein Domain Family
RUN_RUNDC1

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cd17683: RUN_RUNDC1 
RUN domain found in RUN domain-containing protein 1 (RUNDC1) and similar proteins
RUN domain-containing protein 1 (RUNDC1) is thought to a role as p53/TP53 inhibitor and as such may have oncogenic activity. This model contains the RUN domain.
Statistics
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PSSM-Id: 439045
Aligned: 31 rows
Threshold Bit Score: 249.073
Created: 8-Mar-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q96C34       263 KEQLVEQLKTQIRDLEMFINFIQdevgsplqtggghceckaggktgngcsrtgssrtppgnsktkaedv----------- 331 human
XP_002943247 234 KEQLVEQLKTQIRDLEMFIQFIQdevgspvdcsasgtegyspntktnprnkmtpeqarqmrqt----------------- 296 western clawed ...
KPP79925     231 KEQLVEQLKTQIRDLEMFINFIQdevgnpllsdgdhgrqggvsgpnmrgtggkrkvdpeqaqkmr--------------- 295 Asian bonytongue
XP_006006019 224 KEQLVDQLKTQIRDLEMFINFIQdevgspplpqhghcscsthgkgdckhtnakmpsgnskvepeqak------------- 290 coelacanth
XP_006814724 220 KEMVIDQLKSQIGDLERFISFLQgeatspgplgnencdcavhggkgkedgvsddspeccispqihngdt----------- 288 Saccoglossus ko...
XP_012565359 219 KNEIISQVTKQISAMEKLVSFLQeyeeppttipdsvpqhiqrntapaekksvhyqtlkhsekipaphtkilqmteekrkr 298 Hydra vulgaris
XP_011668794 216 KEQVIHQLKNQIVDLERFVVYLQdeaqsplvlsaneepcecevhklappsrdidavsdggsdtqccthpggmkprkkarg 295 purple sea urchin
NP_001315281 203 KEQLVEQLKTQIRDLEMFINFIQdevgssgkaedghcecasrkdgggsfkpniwssgnrvnpedakk------------- 269 chicken
XP_002108010 197 QEQLVKQLTTQVIDLERYISYLQgdtnspgpygrftrmgmpypsqqsvsspprassrksvvsndefsydtnddlsyyad- 275 Trichoplax adha...
XP_007883011 135 KEQLVDQLKTQIRDLEMFINFLQdevgstaqiengkcscdskastsksrysnhqaadseatermr--------------- 199 elephant shark
Q96C34       332 ---------------------------------kkvretglhlmrralavlqifavsqfgcatgqipptlwqrvqadrDY 378 human
XP_002943247 297 ---------------------------------------rlhllrralavlqmfavsqfgcgtgavpanlwkqdesnrDF 337 western clawed ...
KPP79925     296 -------------------------------------etglqliqralavlqifavsqfgcaaghvpqrvwsqgngaqDY 338 Asian bonytongue
XP_006006019 291 ----------------------------------kmretslhlmrralavlqifavsqfgcatgqiprglwqqdeanqDY 336 coelacanth
XP_006814724 289 ---------------------------------dksreknirvlkraltvlqlvavtqfgcgasklrenpppdkntekGC 335 Saccoglossus ko...
XP_012565359 299 lheaslaiikkslallqifaisqfgcsakhfreymirktfaqdnspsgfskcfdevrasvdqiivlhtklinidglhpDS 378 Hydra vulgaris
XP_011668794 296 ktkeelk-------vqktfivlpgvlrilrlasrnsrsqllknekslavlqkiqishlgcgngmdkkptrrgkddigaDY 368 purple sea urchin
NP_001315281 270 -----------------------------------mretglhlmrrmlavlqifavsqfgcatgqiprslwqkdqtnkDY 314 chicken
XP_002108010 276 -----------------------sissidakrqlqastanvkepemtfvrrmlkildifgggsddlrigvkplvptkiDT 332 Trichoplax adha...
XP_007883011 200 -------------------------------------eaglnlmrralavlqifavsqfgcatgqiprglwqtdetnkDY 242 elephant shark
Q96C34       379 SPLLKRLEVSVDRVKQLALRqqphdhvitsa--------nlqdlslggkdELTMAVRKELTVAVRDLLAHGLYasspgms 450 human
XP_002943247 338 SPLIKKLEESVEKVRQLAQRnqtyehvisys--------stkelsmggkdELTIAVRKELAVAIRDLLSHGLYatsqgms 409 western clawed ...
KPP79925     339 GPLLRRLEGAVERVRQLAVSrqhsdehvvsy---------ssgtvgrgrdQLTATVRKDLAMALRDLLAHGLYspsqgms 409 Asian bonytongue
XP_006006019 337 APLLQKLESSVDKVRQLALKrqqpnehvisys-------siqdislggkdELTTAVRKELAMALRDLMSHGLYmssqgms 409 coelacanth
XP_006814724 336 EELLKRLEKAVDYVYELARVhlheappsdndyt----sdseetpwtrpldEVTIGVRRKLAPALRDLFQHGLMkmsrnrs 411 Saccoglossus ko...
XP_012565359 379 EDELNVSMLSTAEKRAAWRHsssmsrsrtdsitssissisvkppeveiqnQLIRIVRGNLTSALKEILQHGLCvsfsnat 458 Hydra vulgaris
XP_011668794 369 YDLLQALDKATEQVIELAKKkqiqdeldkdyyd----sdssdspvsrpldEVTIAVRRELAPALRALFEHGLVrmstsqa 444 purple sea urchin
NP_001315281 315 SPLIKKLELSVDRVRQLALKhqqddhvisss--------dlqdislggrdELTLAVRKELTIALRDLMAHGLCassqgms 386 chicken
XP_002108010 333 RYTISKLDEAVDRIIAVKCQmvergelqks----------ldlitsnspnELFKIISRHFTNNFTLLLQHGLCettetsl 402 Trichoplax adha...
XP_007883011 243 SPLLLKLEAAVNKVKQLTLSrpqggeehvis---------sqdlclsgkdSLTLAVRKELCVALRELLAHGLYassqgms 313 elephant shark
Q96C34       451 lvmapi-acllpafssapeaMHPWELFVKYYHAKNGrayvesparklsqs-falpvtggtvvtpKQSLLTAIHMVLTEHD 528 human
XP_002943247 410 lvlapi-aclipvfstspptMHPWELFVKYYNEQNGkafvesparklsqs-fslpvsgnskvtpKQSLLTAIHTVLTEHD 487 western clawed ...
KPP79925     410 lvlapi--acllpfspgpqaLHPWELFLKYYHSKNGqafvesparqlsqsfglpvgagpvtitpKQSLLWAVHSVLRDHD 487 Asian bonytongue
XP_006006019 410 lvlapi--scllpfssspqtMHPWDLFVKYYNTKNGrafvesparklsqs-falpvtggavvtpKQSLLTAVNTVLTEHD 486 coelacanth
XP_006814724 412 vmlpis--clvpraskvstkIHAWEVLVEYYEMKNGlrytssparklsqs-fkldiiggaaitgKQTLLTAIDSVRASHE 488 Saccoglossus ko...
XP_012565359 459 lstkal-vgcmssqsieglsLHIWEYFNKFYQLKQGdifntqpsmmlse--afamdvgctqqtpKQSLLTVLHRIKTTHE 535 Hydra vulgaris
XP_011668794 445 lmtpit--aclapqrsavpnVHAWEVFSKYFEIKKGkqfaesparrlsqa-fdldivggtaitsRQTLLAAIDHVEATHQ 521 purple sea urchin
NP_001315281 387 lvlapi-aclipaftsspqtMHPWELFVEYYKTKNGqafvesparklsqs-falpvsggvtitpKQSLLTAVHTVLTEHN 464 chicken
XP_002108010 403 lapmscfafmksnnedtsnaMHPWQLFVRFYNSRHGsnynenparrlshs-fgndavgiksnsvKQTFLATVYDIISSPE 481 Trichoplax adha...
XP_007883011 314 lvlapi-acllpsfttspqtIHPWQLFVKYYHSRNGrafvesparklsqs-fslpvggggsitpKQSLLSAVHTVLTEHG 391 elephant shark
Q96C34       529 PFKRsaDSELKALVCMALNEQrLVSWVNLICKSgsLIEPHYQPWSYMAhtGFESALNLLSRLsSLKFSLP 598 human
XP_002943247 488 PFKRgaDSEFKALICMALNEQrLVSWLNLLCKSgvLIQTHYQPWSYMAssGFESALNILSRLsTLKFSLP 557 western clawed frog
KPP79925     488 PYKRgaDSEFKALVCMALNEQrLVSWVNLLCKSgtLVQQHYQPWSYMAqtGFEGALRTLGRLsHLKFSLP 557 Asian bonytongue
XP_006006019 487 PFKRsaDSEFKALVCMALNEQrLVSWVNLICKSgvLVQNHYQPWSYMVqtGFESALNILSRLsNLQFSLP 556 coelacanth
XP_006814724 489 PLKRslDSQFKAFVCEGLNEHkLATWCRLLARTpsIIDMHYTSWSYMQktGFEKAIQQLDRLtPLNFYLP 558 Saccoglossus kowalevskii
XP_012565359 536 PRKRsfDAMFKALISAALNRGrLAQWIRLVIRCpeLVDNHYERWSYVIrtGFDEVLTTLEKLsSLTFFLP 605 Hydra vulgaris
XP_011668794 522 PLRRsnEARFKAFVCQALNEQkLASWCRLVCRThtLMDSFYQSSSYMLrsGFDGGIQILDKLsDIKFCLP 591 purple sea urchin
NP_001315281 465 PFKRsaDSELKALVCMALNEQrLVSWVNLICKSgaLVQSHYHPWSYMVntGFESALNILSRLsSLKFSLP 534 chicken
XP_002108010 482 VRYKtdDFKLRALIFAGLHSQkLTQWCKLISSSrnLMEAHYQSWAYVAngGFSEIIDVIEKLsPLKFDLP 551 Trichoplax adhaerens
XP_007883011 392 PYKRsaDSEFKALVCMALNEQrLVSWVNLICKSgtLLQRHYQPWSYMActGFESSLNILSQLsNLHFNLP 461 elephant shark
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