Conserved Protein Domain Family
O-FucT-2

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cd11298: O-FucT-2 
GDP-fucose protein O-fucosyltransferase 2
O-FucT-2 adds O-fucose to thrombospondin type 1 repeats (TSRs), and appears conserved in bilateria. The O-fucosylation of TSRs appears to play a role in regulating secretion of metalloproteases of the ADAMTS superfamily. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.
Statistics
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PSSM-Id: 211384
Aligned: 30 rows
Threshold Bit Score: 329.231
Created: 26-Sep-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
GDP-Fucose
Feature 1:GDP-Fucose binding site [chemical binding site]
Evidence:
  • Comment:by similarity to other members of this family

cd11298 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd11298 is a member of the superfamily cl16914
Sub-family Hierarchy
cd11296O-FucT_likecd11298O-FucT-2cd11299O-FucT_plantcd11300Fut8_likecd11301Fut1_Fut2_likecd11302O-FucT-1cd11548NodZ_like
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   ####                                                                  
Q00P34         36 YLLYDVNPPEGFNLRRDVYIRMASLVKTLRkeg-----------------gdWVLVLPPWGRLYHWqssd---------- 88   Japanese medaka
XP_003387862  830 YISYTVNMGEGFNLRRDVHMRAANLVRSLRtkt----------------kydWILVLPPWPHLYHWkssv---------- 883  Amphimedon qu...
XP_001635027    3 FLIYDVNPGEGFNLRRDVYMRVANLVKLLNkk------------------qsWVLVTPPWRRLYHWrsri---------- 54   starlet sea a...
XP_002116556   42 YLIYDVNDSEGFNLRRDVYMRIANLIIQLNqrq----------------hyhWTLVLPPWKRMYHWrstps--------- 96   Trichoplax ad...
XP_002160070   50 FLIYDVNPGEGFNLRRDVYTRVANLVKSLNdkg-----------------qdWVLVVPPWMHLYHWksry---------- 102  green hydra
XP_002569587   11 YLFYDVFYGEGFNLRRDVYIRVANTVRLLRdpsqipdfalhninvknltgddWILVLPPWGPLPHWfndrsyerytnhsy 90   Schistosoma m...
XP_002258365   51 YILYDVNLGEGFNLQKEVLYRVALAVYYLNqevr---------------tqvHYLVLPPWCYLTHWgrek---------- 105  Plasmodium kn...
XP_741812      48 YLLYDVNIGEGFNLQKEVLYRMSLVIYQLNkqdk---------------eyiYYLVLPPWCYLSHWank----------- 101  Plasmodium ch...
XP_002142196   59 WILYDVKYGEGFYMQKDVFYRMALVVAHLNnmkqtkq--------ykqnnqtHVLVLPPFCNIAHWsyr----------- 119  Cryptosporidi...
Q8I360         48 YIMYDVNIGEGFNLQKEIFYRLSLVIYNLNkkdk---------------iniYYLVLPPWCYVTHWnir----------- 101  Plasmodium fa...
Feature 1                                                                                         
Q00P34         89 -idqtRIPWGEFFSITSLQAnvPVVEYEEFIAENggpfidqvlv-------lqnyaegwtdGKWEEKIDERPCFDklmys 160  Japanese medaka
XP_003387862  884 --pqdWLPWGQFFDVESLNEyvPSIELETYIEREglvideilsl-------qrlekpftdkGEWLESVTEEPCHQri--- 951  Amphimedon qu...
XP_001635027   55 --eqtGLPWRTFFDMKNLARyvPVIDFDQFLKVNggtgideiiy-------lqryaegwkdGVWEEKIDDRDCIDnpvyy 125  starlet sea a...
XP_002116556   97 -pkqfPLPWKTFFDISSLNKfiPVMEYQDYINQFgqtideiiyl--------qpypdpfegGQFVDKVEETNCQSnqkyk 167  Trichoplax ad...
XP_002160070  103 -isqhGVPWRAFFDLPSMNLyvPVIEFTDFTKVTgskkiehily--------lqrhsdnfkNGFKDLAEIESCKEremyh 173  green hydra
XP_002569587   91 fnnwsGIPWSMFFDLNSLSLfiPVMDLIEFQRSNvldsqqsllnrssnhlltvdlalqlvrGDFNRQLEQYSNDNdrkvd 170  Schistosoma m...
XP_002258365  106 --khnRIKWSVFFNMKVLQNviPVIEYTEYEKEFgphadyi-------------lsyrhfiGDWSKMNEKKSFQFldiek 170  Plasmodium kn...
XP_741812     102 --rhaNLQWDIFLNTNIIKNviPIIEFSEYKKLYgdvtdfiisf-------kyllnsqaskTKYYHGLPFDKCPIedykf 172  Plasmodium ch...
XP_002142196  120 --tkrRLKWSLFFNIQQWES--PTIEYDIFSSLHqpvytddlnik------dssitaiylsFDWNDKQTKRDYNIervsl 189  Cryptosporidi...
Q8I360        102 --kgnNLRWEFFFNTDIMKKviPIIEYEEYEKLYgnysdimin---------skyildnykEKSFLILPFEECNInvnrf 170  Plasmodium fa...
Feature 1                                                                                         
Q00P34        161 kd------------------------------kqgyyrGWFWGYEETRARNVT--------CVSAQGHASIMAPVLQRNY 202  Japanese medaka
XP_003387862  952 -------------------------------------rKDLFSPLDFNVKLMS--------CLTTQGRTSSLSANNFRSF 986  Amphimedon qu...
XP_001635027  126 k-------------------------------dggkyrGYFWGMADVYARKFK--------CVSVQGTAAIMEPYLLDKI 166  starlet sea a...
XP_002116556  168 l-------------------------------mngnyyGYFFGLKGITARKLR--------CMLAQGMTSIIIPKLQQSK 208  Trichoplax ad...
XP_002160070  174 kd------------------------------gkgryrGYFWEIDGVFAEKHD--------CLSVQGHTTAIENILKTLK 215  green hydra
XP_002569587  171 fcpfelrksyrlnsvcyvarqpsrdvgdscftpdirpmELFEGNSFNLQNGILpmtasaydCITGDLEPIHLAPFLIQLI 250  Schistosoma m...
XP_002258365  171 chvenykl-----------------kknlckncdykysVVYSGNCANVKGKKTe-------CLEFFFITSYFVSSTLSDI 226  Plasmodium kn...
XP_741812     173 ktvc--------------------------nncdykysVTYSGDCTNIKGKNVi-------CYGDYIVTSYFVNSVVHKL 219  Plasmodium ch...
XP_002142196  190 nisdenstqky-----------ikcdmsslkkqynvrnTNYSGNCNYLLLEEVy-------CIHFTKILTSETLSIALKN 251  Cryptosporidi...
Q8I360        171 kqfc--------------------------kkcehkynVLYSGYCTTINTKQSe-------CYSYNMISNYFITSILENL 217  Plasmodium fa...
Feature 1                                                                                         
Q00P34        203 tvtsvml------drtetlLHDVYAgk-------dyWDTRRSMVFAKHLRLIGDEFRAKYLnstddrdltvyre------ 263  Japanese medaka
XP_003387862  987 vvmw-----------fellLHDEFGsi-------dyWNARKSMVYAQELRDIGTEFMKDHLdydpgigk----------- 1037 Amphimedon qu...
XP_001635027  167 ksrsvfi------drfeevLHIHYGqk-------dyWEARRSLVFAKHLRDEGDKFRRKVLqstdeedntlmde------ 227  starlet sea a...
XP_002116556  209 arlill-------draenlLHEAYGqv-------gyWNSRRSLVFAKHLRDEGNRYRQEILnstdeqdhivrhs------ 268  Trichoplax ad...
XP_002160070  216 arsfli-------erfealLHVNYGsv-------efWKPRRSLVFAKHLRVLGDEYRQKFLnsndkadktvyae------ 275  green hydra
XP_002569587  251 qnskkpitt-lylgsaqsiIHGHWSews-----qeyWTVRRSITIANHLRDIGDNYRETYLhsndisdrtvspsivehlg 324  Schistosoma m...
XP_002258365  227 fhydi----------dsvlIKHGSNilvsfvnelveANLEDVLPYSEDLINEGNQFVEKNFk------------------ 278  Plasmodium kn...
XP_741812     220 fyihn---------insilIKNGTVilvpfqnelfeNNVEDILLFNERLIYNGNNYIKEILk------------------ 272  Plasmodium ch...
XP_002142196  252 lfhnpiienkwkvslhsviIKFADKilvpwsyelskYNLLNSLEFSTYIENKAMEYMKLHSl------------------ 313  Cryptosporidi...
Q8I360        218 flyni----------tsvlIKQSTNilvpfvnelyqSNLEDILLFNNKLLSYGNNYISNILk------------------ 269  Plasmodium fa...
Feature 1                                # #                                                      
Q00P34        264 ---dwtrmkakpgsakGGPYLGVHLRRKDFiw------------ghREDVPSLKGAVKTILNLMkk------hmLEKVFI 322  Japanese medaka
XP_003387862 1038 --------grskpnkgGGAYLSVHLRSQDYqr------------skPHLVPSLKGLAKQLKTLKke------qkLKVVFI 1091 Amphimedon qu...
XP_001635027  228 ---dwrknkkqegvakGGPYIGVHLRRADFly------------ahPDKVPSLDNVAKQLKKFLkk------ekLEKVFL 286  starlet sea a...
XP_002116556  269 ---dwrllnvkkskkrGGNYLAVHLRRRDFlq------------grKNDIPSLEEAVLQIKSAMkk------tnLSKVFL 327  Trichoplax ad...
XP_002160070  276 ---dwrdqhpqegsalGGPYIAVHMRRGDFsy------------arKETVPTIEQYAQNAENMLkk------ykLKNIYL 334  green hydra
XP_002569587  325 pgsnwlrsqwplspalGGPYVAVHWRRGDFvttstsattttttvttTSRSPNSVLAAQQILNAVkifnqyedhyIDTIYL 404  Schistosoma m...
XP_002258365  279 ---------------sNNNYISCHLRYTDFrk------------isTYDVSPIEISLLKLLYIMfl------rkSSIIFV 325  Plasmodium kn...
XP_741812     273 ----------------SNNYISCHLRYTDFkk------------itSYDVPSVQLAIFKLLYIMfm------nsKDKIFI 318  Plasmodium ch...
XP_002142196  314 ---------------dSQKFIGIHIRRGDFvy------------fhKDEIPSFRNISLRISELMke------lnISKVVI 360  Cryptosporidi...
Q8I360        270 ----------------TNHYISSHLRYTDFky------------isRYNVPPIHIALLKLLYIMfi------nnCRIIFI 315  Plasmodium fa...
Feature 1         ###                                         #                  ###              
Q00P34        323 ATDAdgeELKELKAML-------PRMVRFEPSredlellKDGGVAIIDQWICSHARFFIGTSVSTFSFRIHEEREILGFD 395  Japanese medaka
XP_003387862 1092 ASDAgisGIKKLRKLIg------GKVVWFEPDsdiihryGDGGVAIIDQWIAAHSKFFVGTTESTFSFRIREDRQFLRFS 1165 Amphimedon qu...
XP_001635027  287 STDAdqsGKCNVDYLKs-----kLPIVKYDPPqrilekfGDGGVAIIDQWICAHARFFIGTCESTFSFRIYEERDILGFH 361  starlet sea a...
XP_002116556  328 ATDAeesGLNSIRDQMei----mLCYVTTTPDriq--qfGDGGIAIIDQWICAHAKYFIGSKESTFSFRIYEERELMGFK 401  Trichoplax ad...
XP_002160070  335 STDAtdeEIEEFKSNVf------GKVFIYPRPrefiekyKDGGVAIIDQWIAAHARYFIGTCSSTFSFRIYEERDILGFS 408  green hydra
XP_002569587  405 ATDAdkkELENLKSLLy-----pLQIFHFEPTefewisyGPGGSAIIDQWICAHARYFIGTSSSTFTFRIIEERSIMGFL 479  Schistosoma m...
XP_002258365  326 STDEkkqVKKVIDRQFsq---ykNFFFFYENEk-----lHTGQVAIIDQWICIRSGTFVGNIFSRFSMHIKWERSLIGKG 397  Plasmodium kn...
XP_741812     319 STDEkksVQYIINKHFkq---fkHFFYFYENKdn----yHEGQVAIIEQWICDNSSIFVGNIFSRFTMHIMWERYLITKG 391  Plasmodium ch...
XP_002142196  361 STDAennDLKKMKTILgsivdinLHFLGDIPNlt---hkEDGLIAAIHQYIILQSNYFVGTKESRFTSSIRWQRIVNGKS 437  Cryptosporidi...
Q8I360        316 ASDEkveIQKVINKDFhq---ykKHFYFYNNQnn----lHEGEFSIIEQWICTRSYIFIGNIFSRFTMNINWERHLINKG 388  Plasmodium fa...
Feature 1                    
Q00P34        396 PKTTYNRFCGD 406  Japanese medaka
XP_003387862 1166 VDSTFNQLCGN 1176 Amphimedon queenslandica
XP_001635027  362 GDQTFNCLCGD 372  starlet sea anemone
XP_002116556  402 SKMTYNQLCNH 412  Trichoplax adhaerens
XP_002160070  409 GETTHNCFCAK 419  green hydra
XP_002569587  480 SNTTLNNLCPN 490  Schistosoma mansoni
XP_002258365  398 GQDHNLDLCGY 408  Plasmodium knowlesi strain H
XP_741812     392 KENQNLDLCGY 402  Plasmodium chabaudi chabaudi
XP_002142196  438 LDSSTEYFCSN 448  Cryptosporidium muris RN66
Q8I360        389 QINQNIDLCSY 399  Plasmodium falciparum 3D7

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