Conserved Protein Domain Family
ASKHA_NBD_NTPDase3
?
cd24112: ASKHA_NBD_NTPDase3 
nucleotide-binding domain (NBD) of ectonucleoside triphosphate diphosphohydrolase 3 (NTPDase3) and similar proteins
NTPDase3 (EC 3.6.1.5), also called CD39 antigen-like 3 (CD39L3), Ecto-ATP diphosphohydrolase 3, Ecto-ATPDase 3, Ecto-ATPase 3, Ecto-apyrase 3, or HB6, has a threefold preference for the hydrolysis of ATP over ADP.
Links
?
Statistics
?
PSSM-Id: 466962
Aligned: 6 rows
Threshold Bit Score: 735.808
Created: 26-Jan-2023
Updated: 27-Apr-2023
Structure
?
Aligned Rows:
Download Cn3D
 
Feature 1:putative catalytic site [active site]
Evidence:
  • Comment:The carboxylate group of E165 in NTPDase2 (3CJ1) serves as a catalytic base and activates a water molecule, which is well positioned for nucleophilic attack on the terminal phosphate.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
O75355        57 YGIVLDAGSSRTTVYVYQWpaekenntGVVSQTFKCSVKGSGissy---gnnpQDVPRAFEECMQKVKGQvpshlhgsTP 133 human
NP_001308493  41 YGIVLDAGSSRTTVYVYEWpaekendtGVVSQTFKCDVKGPGissy---ehntGALAKPLDECLNKVKERipvhlhksTS 117 chicken
AAH73611      70 YGIVLDAGSSRTTVYVYQWpaekenntGVVSQALKCNVKGRGissy---ahepEKSPKNIDDCIKKVKEVipanqhnsTP 146 African clawed ...
NP_001077050  40 YGIVLDAGSSRTTVYLYEWpaekenntGVVSQTTKCQVQGPGisdlgldrdqdQNTWYSLKECMKKMTEAipshqhnsTP 119 zebrafish
XP_014343044  41 YGIVIDAGSSRTTVYVYSWpaekenntGVVKEAYKCNVTGPGissy---asnpPKAARSLEACMNETKKIipvplhkdSP 117 coelacanth
XP_007896326  40 YGIILDAGSSRTTAFVYQWpaekkhntGLVTEKYHCRIEGPGiaty---kenpKQAAIAILDCLNRTLKIipkerystTQ 116 elephant shark

Feature 1                                                        #                               
O75355       134 IHLGATAGMRLLRLqnetAANEVLESIQSYFKsqpFDFRGAQIIsGQEEGVYGWITANYLMGnfleknlwhmwvhphgve 213 human
NP_001308493 118 LYLGATAGMRLLRLqnetAANEVLASIQNYFRaqpFQFRGAHIItGPEEGVYGWITANYLMGnflernlwrawvhpyrre 197 chicken
AAH73611     147 AYLGATAGMRLLKLknesAARGVLASIHDYFQtqpFDFRGANIIsGQEEGLYGWITVNYLMGnflekniwrawvrpdgae 226 African clawed ...
NP_001077050 120 VFLGATAGMRLLHMtnegRSNDVLTQMKNYLSslpFKFQNASIIsGQEEGLYGWITVNYLKGnfleknlwnawvhphgak 199 zebrafish
XP_014343044 118 VYLGATAGMRLLKLqnetAANAVLSSIEDYFKflpFDFRSARIItEQEEGVFAWITANYFLDnfleknvwnawvrrdgse 197 coelacanth
XP_007896326 117 VCLAATAGMRLLELqdkpAAQRILSEIEALFKtlpFNFGRVHILtGREEAIYAWISANYLKGnlvkrnnkq-yrhpfivr 195 elephant shark

Feature 1                                                                                        
O75355       214 tTGALDLGGASTQISFVagekmdlntsDIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQnsptknhLTNPCYPRD 293 human
NP_001308493 198 tMGALDLGGASTQISFIpedsq-enfnNTMQVKLYGYDYNVYTHSFQCYGRDEAEKRLLALLLQksstnssVDNPCYPRN 276 chicken
AAH73611     227 tTGALDLGGASTQISFLpekse-qnpnSTVEVTLYGYLYNVYTHSFQCYGRDEAEKRFLASLAQdpk-lkfYENPCYPRN 304 African clawed ...
NP_001077050 200 tVGSLDLGGASTQIAFAtsdd--akgeDIIKVSLYGYEYNIYTHSFLCYGKNEAEKRVLAKLAKepinwanVKHPCFPTG 277 zebrafish
XP_014343044 198 tVGALDLGGASTQIAFIpkept-eglnSTVMVTLYGYQYEVYTHSFQCYGKNEIEKRFLAILVQtslsvsmVDNPCYPRG 276 coelacanth
XP_007896326 196 tSGALDLGGASTQIAFTprril-nklaTPAKVMLYGHKYVIYTQSFECYGKDEAERRYLVNIYQaseskwpYQSPCWPSG 274 elephant shark

Feature 1                                                                                        
O75355       294 YSISFTmghvfDSLCTVDQRPesynpnDVITFEGTGdPSLCKEKVAsifdfkaCHDQETCSFDGVYQPkiKGPFVAFAGF 373 human
NP_001308493 277 YKTALTvkyfcGSLCTQSLRPtnyypdQSVIYHGTGdPGLCQEMVSllfnfstCRSQEDCPFNGIHQPkvKGNFVAFSGF 356 chicken
AAH73611     305 YTVNLSmehtfGSMCTAHFRPanydpnRLITFKGTAdPVLCSEKVSslfdftsCQGKENCSFDGIYQPkvKGNFSAFAGL 384 African clawed ...
NP_001077050 278 YNTSIPaeeifGSECTKNNVPsrydpkRSITFFGQSnPEQCKALVRsifdltsCQGTENCSFDGVYQPplNGDFTAYAGF 357 zebrafish
XP_014343044 277 YHVSFMmgnifQSLCTESQRPekynpeQTVTFVGTGdPAVCKEKVSlvfnfpsCDRKENCSFDGVYQPsiNGKFVAFAGF 356 coelacanth
XP_007896326 275 YNETVSmkdlfGSLCTASKKPanykpdDEITFTGTGnPAKCQELVYllfdfkaCAGKHYCSFSGIYQPtvRGKFMAFSAF 354 elephant shark

Feature 1                                                                                        
O75355       374 YYTASALNLsgsfsLDTFNSSTWNFCsqNWSQLPLLLpkfdevYARSYCFSANYIYHLFVNGykfteetWPQIHFEKEVG 453 human
NP_001308493 357 YYTINALNLtghftLTDFNSSMWFFCsqSWAQLQFMLpkseeiYARSYCFSANFIYYLLVRGynfdagnWPQIHFQKEVG 436 chicken
AAH73611     385 YYTTSALNLtgyfqLNQFNSSMTSFCakEWSQLPHILhrfeetYARSYCFSANFIYYLLVRGykfdnetWLHINFQKEVG 464 African clawed ...
NP_001077050 358 YWTALALKVngsnsMEKFNTNMKLFCsnDWKNLKQNYenk-dsHLKSFCYSANYVHTILADGykfntdnWENLEFSKEVN 436 zebrafish
XP_014343044 357 YYITEALNLtgkfpLDTFNSTVWSFCsqNWIKLQAILpnaeekYIRSYCFAANYIYNLLVRGykfdsetWPQISFQRNAG 436 coelacanth
XP_007896326 355 YYTKRALKLptsftLTTFTETLWSFCtkSWAELKVMLpkdkdrYRKGYCFSGNYMRTLLISGykfkpasWKRISFNKKVD 434 elephant shark

Feature 1                       
O75355       454 nssiaWSLGYMLSLT 468 human
NP_001308493 437 nssiaWSLGYMLSLT 451 chicken
AAH73611     465 nssiaWSLGYMLTLT 479 African clawed frog
NP_001077050 437 ntsiaWSLGYMLALS 451 zebrafish
XP_014343044 437 nnsitWSLGYMLNLT 451 coelacanth
XP_007896326 435 gnevnWSLGYMLNVT 449 elephant shark

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap