5NPV


Conserved Protein Domain Family
APG5

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pfam04106: APG5 
Autophagy protein Apg5
Apg5 is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway.
Statistics
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PSSM-Id: 461175
Aligned: 135 rows
Threshold Bit Score: 106.51
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5NPV_A                    86 WHYPIGLLFDLLas----------------------------------------------------------ssALPWNI 107
Q54GT9                    80 WHLPIGVLYDTIvgnnncnnsnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnniimeqpY--WNI 157 Dic...
EGC33469                  80 WHVPIGVLYDTLvlsksg--------------------------------------------------gvieqpY--WNI 107
EFA82416                 102 WHIPIGVLFDMLvatpd----------------------------------------------------ttasqI--WNI 127
XP_004367116              81 WHLPIGVLFDVLvgses--------------------------------------------------------gtqiWNL 104
XP_004987834             109 WHVPVGVLFDALtgdi-------------------------------------------------------ddvgRPWEI 133
WGS:AAFB:cds.EHI_022880A  81 WYFPIGVIFDALhn-----------------------------------------------------------gsLPMEI 101
XP_002638926              78 MYIPVGVIYDQLnqkn-------------------------------------------------------lesEGILEI 102
EGT38992                  78 MYVPIGVIYDQAki----------------------------------------------------------eaESILEI 99 
3_pfamImport               1 MYAPVGVLYDLQnl----------------------------------------------------------erDQILEI 22 
5NPV_A                   108 TVHFKSF-PEK-DLLHCPSKDAIEAHFMSCMKEADALKHKS-QVINEMQKKDHKQ----LWMGLQND--------RFDQF 172
Q54GT9                   158 VVHFQSY-PDR-ILLRCPNIESVRTYYKNVLKEANFIKQGDiTKINNLNINQSND----LWDGLKSH--------DYDKF 223 Dic...
EGC33469                 108 VVHFQSY-PDK-ILLKCPNIEAVRTYYKNVLKEATFIKQGDiNKFNNLTINQSND----LWDGLKNH--------DYDKF 173
EFA82416                 128 TVHFQSF-PEK-VLLRCSNEDAIRTYYKNVLKEANYIKQGDiNKLNNLSINQTNE----LWDGLKLH--------DYEKF 193
XP_004367116             105 TVHFQSF-PEK-ILLRCPNEESVETYYKNVLKEANYIKQGDiNKLNNLNINQSNE----LWDGLRQHifpffhvdDYDKF 178
XP_004987834             134 TVHTKNF-PAK-ALLPYSTIEDLQRHFLCRLKEACFIKQGT----LNLDELGDVQtlkrLWSGLLYD--------NYNDF 199
WGS:AAFB:cds.EHI_022880A 102 TIGIS---QNQsTFQPYENEETIKNYHIQQLKESVYLRYGSiQTIRQLAVESITP----LWEFHAQN--------KLEEY 166
XP_002638926             103 HVRTSQPaPLD-FQMV--SVDSMRAMFCQTVKEADYLKTKA-EVTSSLMKEDMPQ----LWQSVVNN--------NFDEY 166
EGT38992                 100 SVKTTPP-PAN-FQMV--DQETMKAMFMQNIKQADYLKTEA-AVTQAMMKDELPQ----LWRSVVNN--------NFDEF 162
3_pfamImport              23 TVKTSSP-PPG-FVPI--DRNAMEAIFMQSIKEADYLKTKA-ATTNNMQKEEYAQ----LWRSVTNN--------NFDEY 85 
5NPV_A                   173 WAINRKLMEYPaeE------NGFRYIPFRIYQ--TTTeRp-------FIQKLFRpvaad--gqlhTLGDLLKEV-CPSAI 234
Q54GT9                   224 WSVNKKLIPNS--N------KEYKNIPIRLII--NYK-P--------PIQELIPvfden--lvelTLENLFSRIpYES-F 281 Dic...
EGC33469                 174 WSVNKKFAPNS--Y------KEYKNIPIRLII--NYK-P--------PVQELIPvydgenstteiTLENLFSKIpYDSVs 234
EFA82416                 194 WSINKMFYPG----------NGYKHIPYRIIQ--NNK-A--------PLQDLISpinen--gqetTLESLFSKIafnnsn 250
XP_004367116             179 WSINKLFYNVN--VggsstgIGYKHIPVRLIQ--NNR-P--------YVQNLIApynes--gaelTLSDYFSKIpFYSIF 243
XP_004987834             200 QDVNQHLMSTP--Dn-----NWFKQFPFCLYMtaRTG-DtgpweitqMVREPFGvadde--gmplTLSDLLSVL-LGGGF 268
WGS:AAFB:cds.EHI_022880A 167 EQLLNPILITG--E-------NWQNIPIHWYF--GSQ-RrytdcipvIINDHLT-----------TLIEGLQVF-LKERD 222
XP_002638926             167 WGMIQKLMDPK--Dg-----KDFLHVPLRVYVkn-----------qpFKQALITvkhpd--gslrTIGDAVSEIlqlsts 226
EGT38992                 163 WAMNRKLMETD---------KEFKYVPIRVYPgdd----------kpFKQSQIKtkkpd--gsyiTVGEAVGELlqpssy 221
3_pfamImport              86 WTIIQKLMEEK--Dg-----KEFDHIPLRVCMkn-----------kpFKQILISskdks--gsliTIGDAIAQVledsav 145
5NPV_A                   235 --DPEdge--------------------------------------------------------kknQVMIHGIEPMLET 256
Q54GT9                   282 snFLNynnnnnnnninnnspplspnsnnnnnnnnvdnsienslnqtnvesaepefsnllqyikatnaEYKIQGIQPSLKS 361 Dic...
EGC33469                 235 slfnyisnsnntgnlspplspsdrnsaevd-------nniensinqsslppsaeysnllqfmkacgiKYRIQGIEPPLDS 307
EFA82416                 251 nsssnnnnnnnnsnnnsnnnnnidt------------snetqqstttlsssstnsttllqvlnsgsiRYSIQGIEPPLNS 318
XP_004367116             244 igGATepssssptttntgelstss------------------------sstsmaytnllqyikagagKYLIQGVEPPLES 299
XP_004987834             269 tyTNAtattdvdadadddddnggddgddddd-----------gtedkdkkvvmtagedndggekqqvSVIVQGVEPPLDT 337
WGS:AAFB:cds.EHI_022880A 223 inDNDppslqllkt--------------------------------------------nsfeqcpnlCIVIQGITIPLDT 258
XP_002638926             227 seastptse-------------------------------------------ssatssseasspddrRLISHGIDVPRHT 263
EGT38992                 222 stpsssess--------------------------------------------tptstsectilkerRLISHGIVIPYHT 257
3_pfamImport             146 -------------------------------------------------------------adpsdfRITSHGIDVPPHT 164
5NPV_A                   257 PLQWLSEHLSYPDNFLHISII 277
Q54GT9                   362 SAVWLYEHFGHPDNFLYIVLI 382 Dictyostelium discoideum
EGC33469                 308 SAVWLYEYFSHPDNFIYITLF 328
EFA82416                 319 SLIWLGDYFSHPDNFLYIVLa 339
XP_004367116             300 SFLWLGEYFSHPDNFLYITLI 320
XP_004987834             338 PLQWLAAHMSHADNFCHVIVR 358
WGS:AAFB:cds.EHI_022880A 259 PLLWLALNLSHSDLFLHVIIR 279
XP_002638926             264 PLIFAAKNLSYPDNFVHIVIA 284
EGT38992                 258 PLIFAAKNLSYPDNFVHIVIA 278
3_pfamImport             165 PLIFAAKNMAYPDNFVHIVVV 185
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