Conserved Protein Domain Family
RFX_DNA_binding

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pfam02257: RFX_DNA_binding 
RFX DNA-binding domain
RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD).
Statistics
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PSSM-Id: 460512
Aligned: 65 rows
Threshold Bit Score: 95.3093
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_017947767  520 EKFGCQWLNAHFEVCPD---SSVSRSEMYSEYLSTCSKLARgGILTSSGFYKCLRSVFANHNIKRVEdpnNNGQAH-IHV 595 
XP_004995448  292 DEDTVTWLRANFELKTG---FTVERRLVYKAYCRHMQSMMQ-EPCNAAGFGKVIRGVFPGVTSRRLG---SRGHSK-YHY 363 
XP_016292049  125 DKWARMWLTCNYTLKSSi-qISIPRTILHESYRRACDSFGL-EPLQAASFGKVLRSQFPDVAQRRLG---GRGKTR-FHY 198 
XP_002111154  454 ENFAHAWLNATYDCCTG---GYVPRSGMYSDYLATCNRLSItGIVNSTTFSRLIHEVFPSAEIKRV----TYGNTNqYFY 526 
XP_002416101  386 EAFAGTWVRAMYEPAPPg--CSVARNDIYAEYVTFCSKAGRkSVISASVFANCVKAVYSQTGIRRVDn--ANGMMS-FHH 460 
EEN42662      127 ETFTCSWLNSLYEVDSE---GSVARIDLYADYLSSCSKLARvGILTSTHFYRCVKTLFPNTGSKRVD---TNGQVV-YHI 199 
XP_008257582  521 EKFACQWLNAHFEINLD---CSVSRAEMYSEYLSTCSKLARgGILTSTGFYKCLRTVFPNHTVRRVEdssSSGQAH-IHV 596 
XP_015208422  522 EKFTTQWLNAHFEVHSD---SSVSRSEMYSEYLATCSKMARgGILTSTGFYKCLRSIFPNHTVKRMEdpkTNGQAH-IHV 597 
XP_026690016   72 ATITTEWLTKNFEENSL---TSVPRSIMFDEYQKFCRDSNT-KPFNQAVFGKIVRACFPNLTTRRLG---VRGQSR-YHY 143 
EOR02939       60 AQVAREWLLDNFAECEGcedSSVPRQQVYASYTSFCVSHNT-PPAACRIFGKIVRKLFPHVFIRRLG---SRAVSI-YHY 134 
XP_017947767  596 AGVRRRA 602 
XP_004995448  364 EGLRIKP 370 
XP_016292049  199 CGFGTSN 205 
XP_002111154  527 TGVRKRA 533 
XP_002416101  461 DGLRKRL 467 
EEN42662      200 SGIKKRA 206 
XP_008257582  597 VGVRRRA 603 
XP_015208422  598 VGIRRRS 604 
XP_026690016  144 AGLSVKL 150 
EOR02939      135 CGITHRS 141 
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