Conserved Protein Domain Family
RING-HC_MKRN
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cd16521: RING-HC_MKRN 
RING finger, HC subclass, found in the makorin (MKRN) proteins
The MKRN protein subfamily includes ribonucleoproteins that are characterized by a variety of zinc-finger motifs, including typical arrays of one to four C3H1-type zinc fingers and a C3HC4-type RING-HC finger. Another motif rich in Cys and His residues (CH), with so far unknown function, is also generally present in MKRN proteins. MKRN proteins may have E3 ubiquitin ligase activity.
Links
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Statistics
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PSSM-Id: 438184
Aligned: 27 rows
Threshold Bit Score: 69.6142
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #                    # #  #  #                     #  # 
Q9UHC7       279 MVCGICMEVvyekanpserrFGILSNCNHTYCLKCIRKWRsakqf----eskiiKSCPECR 335  human
XP_002109897  68 VSCSICMEDvtakssrterrFGILVNCNHPFCINCIRQWRsstsy----dntiiRACPICR 124  Trichoplax adhaerens
KJE89566     425 VECSICLEVvlskpdpaerkFGILPGCTHPFCLTCIRNWRgstms-----gsviRACPICR 480  Capsaspora owczarzaki ATCC 30864
EFN60083     187 VECSICLEAvlskaapgerkFGLLTGCDHPFCLRCIRSWRqntdgsv-didtalRTCPVCR 246  Chlorella variabilis
EFJ19697     173 IECSVCLERvlskpsmsdrkFGILSGCDHPFCIACIRDWRggtrpgm-dletivRACPICR 232  Selaginella moellendorffii
Q6IDS6       168 IECSVCLDRilskatpgerkFGLLTECDHPFCIQCIRNWRssapvsgmdvnstlRACPICR 228  thale cress
EDO30911     216 VTCAVCLDVvmskpkqserrFGILPNCIHAFCLECIRKWRkasha----ekkvvRACPICR 272  starlet sea anemone
EAL66590     773 LECGICYDSivek----grrFGLLSHCDHVFCLDCIRMWRgtnngaptnnnnavRLCPLCR 829  Dictyostelium discoideum AX4
EER05851     149 VLCAICDDDvvas----gkrFGLLENCDHPFCLECIREWRdqkdtq---drenlRLCPLCR 202  Perkinsus marinus ATCC 50983
EME28819     232 AKCGICLDYprks----gkyFGLLENCDHVFCLECIRQWRqhsid----fgqvvRFCPLCR 284  Galdieria sulphuraria

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