6W6L


Conserved Protein Domain Family
CCDC47

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pfam07946: CCDC47 
PAT complex subunit CCDC47
This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.
Statistics
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PSSM-Id: 462322
Aligned: 154 rows
Threshold Bit Score: 150.026
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6W6L_7       135 SYYLEILMVTGLLAYIMNYIIGKNKNSRLAQAWFNTHRELLESNFTLVGdD-------------------GTNKEATstg 195
CDS36384     125 HYVFEMFFLAFIFLYLVNYMHGRATNSRLAAAWFAAHENLFSTNFSLVG-EdtsatpegnqeretsregeKSSLNRR--- 200
XP_003137608 119 SYQVEALVLSILAVYMLNYIFGRIKNRNIANKWFMDVTPFLEEQFTLVG-Ddg---------------tsEDLREGH--- 179
PDM67749     123 SYQVEAVVIFLLLVYLTNYLAGRAANQSIAFSWVDNHRDRLEEQFAVVG-Ddg---------------lsETPSNGQ--- 183
Q23382       103 SYQVEGIVVLIILIYMTNYLIGKTTNASIAQTIFDMCRPTLEEQFAVVG-Ddgt--------------tdLDKMIPS--- 164 Caenorhabditis ...
XP_001635664  63 GFYVEILTLAGLAAYALNFFAGRTKNSKLATAWLKSHKELLESNFHIVG-Ddg---------------qaEEPQQGI--- 123
OWR49287       7 AYWLEGVLCCLLAAYALVYAIGRAKNTTIATNFLKLHRPLLEDNFTLVG-Esg---------------sdMVPEDRG--- 67 
XP_004926303 125 AYWLEGILCCLLASYALAYAIGRAKNTSIAVNFLKLHKPLLEENFTLVG-Etga-------------evvSGADERG--- 187
XP_012063714 122 SYYLEILMITGLVVYFINYIVGRTKNAHIVEQWLIDHKQLLMDNFSLIG-Hsgk--------------snENANDNG--- 183
XP_008216919 126 SFYLEILMIAGLLVYFFNYIAGKSKNSRIAETFYNDHQGILSENFSLVG-Dtgk--------------ssDEGILNG--- 187
6W6L_7       196 kLNQENEHIYNLWCSGRVCCEGMLIQLRFLKRQDLLNVLARMM-R----------PVSDQVQIKVTMN-DEDMDTYVFAV 263
CDS36384     201 -LIRESDSLYTLWCSGRVACTGMMVELRLMKRQDLPSLFLHWLhRpksgvnaatiASDDRVVVKVVLE-DGEMDTWVMAV 278
XP_003137608 180 -IHKETDSVYTIWCSGRVGCQGILITLELLKRQDLIHVVMNFI-Rp----------KQDKVIIRIDVD-NNEMDSFVFAI 246
PDM67749     184 -LNRETDNLFSMWCSGRVGVSGCMVHIRTIKRQDLVSRIWGIFn-----------KNYDRVTLTFDVD-EGEMDSFVVAA 250
Q23382       165 -LKHDTDSTFSAWCTGRVNVNSLFLQMKMVKRQDVVSRIMEMF-Tp----------SGDKMTIKASLEtTNDTDPLIFAV 232 Caenorhabditis ...
XP_001635664 124 -MVKESESLYSLWCTGRTGCNGMLVELKLQKRHDLVNVMSYLV-Kp----------VKDSITVTVHMT-DEEMDNFVFAI 190
OWR49287      68 -WRREAEHCFTMWCSGRQCCEGMLLTLKLIKRQDLVNVLLGVV-Rp----------NPDTLLIRVELG-KDDNDPFVLCV 134
XP_004926303 188 -WRREAEHCFTMWCSGRSCCEGMLLTLKLIKRQDLVHVLLGVV-Rp----------NPDTLQIRIELG-KDDMDPFVFCI 254
XP_012063714 184 -FIRQSESQYSLYCSGRVGCDSMLIELKLIKRQDLVAVLAQLV-Rp----------QNDQIHIEVELS-KDEIDNFVLAV 250
XP_008216919 188 -PIKESESQYSIYCSGRVGCDSLLIELKLIKRQDLVAVLSQIV-Rp----------QNDQAHLRIEMS-KDETDNFVLAI 254
6W6L_7       264 GTRKALVRLQKEMQDL-SeFCSD----KpksgAKYGLPdS-LAILSEMGEVTDGMMDTKMVHFLTHYADKIESVHFSDQF 337
CDS36384     279 GVKKSIMMLAKDHFDLaT-YPAdr-rgQ----RFNGVP-EgMIVLSEIAEATATILNPTVLKVINDHQSAIEYIYISDQY 351
XP_003137608 247 GQRKSVTKAAKEKMDLsL-FTVer-kgV----DRLGLP-SsIVVYAEMFEAVNAIIDPVILSVFRKYESAIDYFHFSDQY 319
PDM67749     251 GQRKSVTRLHKELLDLsQ-YTTek-kmA----PGPSLP-PsFSLFSESSEVASCLLDNAVLTLAKKYEDNIEYIHISDQY 323
Q23382       233 GEKKIASKYFKEMLDLnS-FASErkqaA----QQFNLP-AsWQVYADQNEVVFSILDPGVVSLLKKHEDAIEFIHISDQF 306 Caenorhabditis ...
XP_001635664 191 VPKKTVSKMQKELQDLsF-FCPdk-ksG----AKYDLP-AsLVILSESNEVANTLLTQQVTKAISNHEDMFESLLFSDQY 263
OWR49287     135 AQKKVATRLSKEMQDLsM-FCPer-rpG----DKHGLP-GsLSVMSECAEATAALLDARVVAALTQFAAHVQYIHVSDRY 207
XP_004926303 255 AQKKIAAKLAREMHDLsV-YCGer-raG----ERLGVP-GaLSVVAECAEPGAALLDARVCAALQLHHRHLLYLHLSDKY 327
XP_012063714 251 ATKRLAMHLVRDMADIsV-YCPek-rsG----EKFGLP-SgFYVMSEIPEATAAILDTRIQQAFTKFAPYIEYIHISDQF 323
XP_008216919 255 AAKKTALHISKDMADIsV-YCPek-rpG----EKFNLP-SgFFVMSEISEATSAILDTRVLQAFNKYGQYIDYIHISDQY 327
6W6L_7       338 S------------GPkimqeegqPLKlpdtkrTLLFTFNVPGS--G-NtypkdMEALLPLMNMVIYSIDK-AkkFRLNRE 401
CDS36384     352 SgpkasmdelkppKP--------EDIq----kVLIFSFIL-------Dek--dVEAMKPLFNFVFYLTEKtRk-LRLGKE 409
XP_003137608 320 Sgykpsd-gesftRL--------PETs----rVLFFAFKMsn----------nMAEIDALLRMVFHCFEKiRr-YRLSRE 375
PDM67749     324 Sgpkppd-getltRL--------PETr----rVAVFSFILh---nQsAey--dREAEDEMIQMAFYCVDKmRr-FRLSRE 384
Q23382       307 Tgpkpae-gesytRL--------PEAq----rYMFVSLNL-----QyLgq--dEESVMEILNLVFYLIDKaRk-MKLSKD 365 Caenorhabditis ...
XP_001635664 264 VgpkqededqaaaKP--------LKPk----kVLIFNFTVASKgnT-Kvq--dMARLESMMKLVLHCIDRvRk-FRLGKE 327
OWR49287     208 Cgpkqme-etsvtKP--------PETe----rVLLASLSLSGEggG--------DEVRPLMLMIFYMLDRiKr-LRLSKE 265
XP_004926303 328 Agpkhle-etastKP--------PETe----rVMLVSLALGPDggG--------DELRPLLQLVFYILDKlKr-FKLSKE 385
XP_012063714 324 Sgrkpqe-dttqlTM--------PEVk----rILLMSLNISLKgrAsNpe--tQEKLKPLLQLAFYLIDKlRr-FKLSKE 387
XP_008216919 328 Sgpkqqe-dttqlTM--------PEVk----rVLLVGLNISIKgrInNae--sQEKIRPLLQLTFYLLDKiRr-FKLSKE 391
6W6L_7       402 GKQKADKNRARVEENFLKLTHVQRQEAAQSRREEKKRAEKERIMNEEDPEKQRRLEEAALRREQKK 467
CDS36384     410 AKAKSDRARTKVSETLLKSVQAARQEAAQNRRDEQRRAVKERIMTEEDPEKARRLEEREQKRENRK 475
XP_003137608 376 GKLKADKKRQSVQEAFLKTTHQARQEAAQARREEKTRERKQRLLEEEDPEKQRRLEKLEQKRDMKl 441
PDM67749     385 AKQKGDKRRQTAQELFQKSNHQARQEAAQARREEKTRERKQKLLEEEDPDKQRRLELLEYKKELKa 450
Q23382       366 AKVKAERRRKEFEDAFLKQTHQFRQEAAQARREEKTRERKQKLMDESDPERQKRLEAKELKREAKa 431 Caenorhabditis elegans
XP_001635664 328 ARAKADKNRRELEENLLKQTHLQRQEAAQLRREEKRRADKERMMAEDDPDRQRRLEERVNKAEAKR 393
OWR49287     266 ALSKCEKRRQKAAEAWVRGAHAARQESAALRREEKRKQEKERILAEDDPEKQRRWELKEQKRQQKR 331
XP_004926303 386 ALAKCEKRRQKVAEAWLRGAHAARQEQAALRREEKRKQEKERILAEDDPEKQRRWELKEQKRQQKR 451
XP_012063714 388 GKNKADKNRLRVEEAFLKTTHAARAEAAAQRREERRRAEQERILQEEDPDKQRKWEEKEQRRLAKK 453
XP_008216919 392 GKSKTDKNRQKVEEAFLKTTHAARAEAAAARREEKRRVEKERILQEEDPDKQRKWEEKEQRRLAKK 457
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