Conserved Protein Domain Family
T-box_TBX20-like

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cd20193: T-box_TBX20-like 
DNA-binding domain of T-box transcription factor 20 and related T-box proteins
TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.
Statistics
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PSSM-Id: 410319
Aligned: 19 rows
Threshold Bit Score: 388.326
Created: 8-Mar-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
DNA binding
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on related T-box transcription factors bound with DNA
  • Comment:T-box monomers dimerize upon DNA binding; some form weak dimers, others tight dimers, some may bind as non-associating monomers where the dimer is kept in register by the DNA

cd20193 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd20193 is a member of the superfamily cl00145
cd20193 Sequence Cluster
Sub-family Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   ##                                    #              
Q9UMR3       100 IACSLEtKELWDKFHELgTEMIITKsGRRMFPTIRVSFSGVDPe----AKYIVLMDIVPVDnKRYRYAY-HRSSWLVAGK 174 human
Q94890       277 VQCHLEtKELWDKFHELgTEMIITKsGRRMFPTVRVSFSGPLRqiqpaDRYAVLLDVVPLDsRRYRYAY-HRSSWLVAGK 355 fruit fly
EFX72115      57 VDCHLEtKELWDKFNELgTEMIITKtGRRMFPTVRVTFSGAQSr----VRYYVLLDVVPVDsKRYRYAY-HRSSWLVAGK 131 common water flea
EKC38761      89 VECRLEtKDLWDKFHELgTEMIITKtGRRMFPTFRVSFTGIDPe----WRYMVLMDIVPVDnKRYRYAY-HRSSWLVAGK 163 Pacific oyster
KFM66498     172 VDCLLEnKDLWDKFHELgTEMIITKtGRRMFPTVRVSFSGAEVh----TKYSVYMDIVPVDnKRYRYAY-HRSSWLVAGK 246 Stegodyphus mim...
XP_013390983 143 VHCRLEtKDLWAKFHELgTEMIITKsGRRMFPTLRVSFSGLESd----AKYAVLMDVTPVDgKRYRYAY-HRSSWLVAGK 217 Lingula anatina
PFX15629      88 ITATLEsRDLWDRFNELgTEMIITKsGRRMFPTLRISLNGVSLg----ANYMVLMDIVPVDdKRYRYAY-HRSTWLVAGK 162 Stylophora pist...
NP_001027590 108 LKCILEtKDLWGKFHELgTEMIITKsGRRMFPTVRVSFCKGDAn----EKYIVVMDIVPVDnKRYRYAY-HRSSWLVAGK 182 vase tunicate
XP_009023093   7 VQCRLEtKDLWDKFFELgTEMIITKsGRRMFPTLRVSFSNLVAdl-erCKFNVLMDIVPVDnKRYRLYAyHRSSWLVAGK 85  Helobdella robusta
PIK58688      89 VQCHLEiRELWERFHELgTEMIITKsGRRMFPALRVSFSGLDPk----SRYIILLDILPVDnKRYRYAY-HRSSWLVAGK 163 Japanese sea cu...
Feature 1                                        #  #            ##                              
Q9UMR3       175 ADPplPARLYVHpDSPFTGEQLLKQMVSFEKvKLTNNelDQHGHIILNSMHKYQPRVHIIKKKdhtasl---lnlkseEF 251 human
Q94890       356 ADPppPSRIYAHpDCPLSPEALRKQVVSFEKvKLTNNemDKSGQVVLNSMHRYQPRIHLVRLShgqsipgspkelqdmDH 435 fruit fly
EFX72115     132 ADPpaPARLYTHpDSPFTPDQLRKQVISFEKvKLTNNemDKQGQIVLNSMHRYQPRVHLVRRMegdttrp-ivdlereQF 210 common water flea
EKC38761     164 ADPplPTRLYMHpDSPFTGEQLQKQTVSFEKlKLTNNmlDKNGHIILNSMHKYQPRIHIVKKKessgnqp-issldaeEF 242 Pacific oyster
KFM66498     247 ADPpsPSRLYLHpDSPFTGEQLKKQVVSFEKvKLTNNemDKQGHIVLNSMHRYQPRIHLVRKSgsttlss-paeleneEF 325 Stegodyphus mim...
XP_013390983 218 ADPplPSRLHIHpDSTFSGEQLHKQTVSFEKvKLTNNmmDKTGHIVLNSMHKYQPRIHLVKLAdttptni--tsldheEH 295 Lingula anatina
PFX15629     163 ADPpaPVRLYMHpDSPFTGEQLLKQIISFEKvKLTNNttDQNGHIVLNSMHKYQPRVHIVRKRdhtasv---vdlhskEA 239 Stylophora pist...
NP_001027590 183 ADPplQPRLYVHpDSPLSGAQVCKQMCSFEKlKLTNNelDQNSHVILNSMHKYQPRIHVIRKDrddtdl---snltkeQY 259 vase tunicate
XP_009023093  86 ADPplPTRLYMHpDSPFTYEQLTKQTVSFEKiKLTNNmlDKTGHIILNSMHKYQPRIRLVLREnlmnd------asteCS 159 Helobdella robusta
PIK58688     164 ADPpiKNRLYLHpDSPYTGEHLSKQMISFEKvKLTNNalDNQGHIILNSMHRYQPRVHLVKAAradpqdl--ekylylTY 241 Japanese sea cu...
Feature 1                     ####    #  ##  #######   
Q9UMR3       252 RTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 289 human
Q94890       436 KTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 473 fruit fly
EFX72115     211 RTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 248 common water flea
EKC38761     243 KTFIFPETVFIAVTAYQNQLITKLKIDSNPFAKGFRDS 280 Pacific oyster
KFM66498     326 RTYIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 363 Stegodyphus mimosarum
XP_013390983 296 RTFVFPETMFIAVTAYQNQLITKLKIESNPFAKGFRDS 333 Lingula anatina
PFX15629     240 KTFDFPETSFIAVTAYQNQLITRLKIDSNPFAKGFRDS 277 Stylophora pistillata
NP_001027590 260 KTFIFPETQFTAVTAYQNQLITRLKIDSNPFAKGFRDS 297 vase tunicate
XP_009023093 160 KIFVFPETIFIAVTAYQNQLITKLKIDSNPFAKGFRDS 197 Helobdella robusta
PIK58688     242 QDIAFRETAFTAVTAYQNQLITRLKIDSNPFAKGFRDS 279 Japanese sea cucumber

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