Conserved Protein Domain Family
bHLH_TS_HAND

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cd11466: bHLH_TS_HAND 
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein (HAND) family
The HAND family includes two bHLH transcription factors, HAND1 and HAND2. HAND1, also termed Class A basic helix-loop-helix protein 27 (bHLHa27), or extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND), plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.
Statistics
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PSSM-Id: 381472
Aligned: 13 rows
Threshold Bit Score: 93.6246
Created: 12-Sep-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #   # ### #    #                 ####                  
O96004        95 RKGSGPKKERRRTESINSAFAELRECIPNVPaDTKLSKIKTLRLATSYIAYLMDVL 150 human
NP_001071729   3 FQRNVRQKEKKRTECINKAFSDLRKCIPNVPsDTKLSKIKTLHLASSYIAYLSDIL 58  Ciona intestinalis
PFX22642      31 PRGSANRKERKRTLTMNTAFAELRDHIPNVPpDTKLSKIKTLRLAISYIKFLMEIL 86  Stylophora pistillata
P61296       100 RRGTANRKERRRTQSINSAFAELRECIPNVPaDTKLSKIKTLRLATSYIAYLMDLL 155 human
AEL13770     112 PRGSANKKERRRTQSINSAFAELRDRIPNVPaDTKLSKIKTLRLATSYIAYLMDVL 167 Florida lancelet
ELU12749     108 KPGNNNKKERRRTHSINSAFASLRGCIPNVPsDTKLSKIKTLRLATSYIAYLMDVL 163 Capitella teleta
NP_609370     59 KRNTANKKERRRTQSINNAFSYLREKIPNVPtDTKLSKIKTLKLAILYINYLVNVL 114 fruit fly
XP_013402923  88 RRVSANKKERRRTLSINTAFADLRGCIPNVPsDTKLSKIKTLRLATSYIAYLMDIL 143 Lingula anatina
XP_023330366  96 KIVGSNKKERRRTQSINAAFSSLRDCIPNVPcDTKLSKIKTLRLATSYIDYLLNVL 151 Eurytemora affinis
KPP58716     130 CDGKRGRKERRRTQSINSAFADLRERIPHVPaDTKLSKIKTLRLAASYISHLMDLL 185 Asian bonytongue
XP_011665162 223 EAVVGNRKERRRTQSINTAFADLRECIPNVPaDTKLSKIKTLRLATSYIAYLTDMV 278 purple sea urchin
AGD79968      84 RRCSANKKERRRTQSINSAFADLRDCIPNVPtDTKLSKIKTLRLATSYISYLMDLL 139 Saccoglossus kowalevskii
KOF83310      89 RRVTANKKERRRTQSINMAFAQLRGCIPNVPsDTKLSKIKTLRLATSYIAYLMDVL 144 Octopus bimaculoides

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