Conserved Protein Domain Family
bHLH_E-protein_Da_like
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cd11467: bHLH_E-protein_Da_like 
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein daughterless (Da) and similar proteins
Da is a nuclear bHLH transcription factor that is a sole E protein ortholog essential for both neurogenesis and sex determination in Drosophila. Da is expressed in a broad range of tissues and is involved in diverse developmental processes such as oogenesis, sex determination and neurogenesis depending on its bHLH-binding partners. Da and achaete-scute complex (AS-C) form heterodimers that act as transcriptional activators of neural cell fates and are involved in sex determination.
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Statistics
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PSSM-Id: 381473
Aligned: 6 rows
Threshold Bit Score: 128.994
Created: 3-Oct-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on structure evidence that Mus musculus E47 (2QL2)-NeuroD1 complex binds DNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #   # ### #    #                    ##                              
118249       554 ERRQANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACL 623 fruit fly
EFX66883     585 ERRQANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMQLEQQVRERNLNPKAACL 654 common water flea
XP_023324914 236 ERRSSNNARERIRIRDINDALKELGTICMSHLKSDKPQTKLGILNVAVDVIMNLEQQVRERNLNPKVACL 305 Eurytemora affinis
XP_018022806 468 ERRHANNARERIRIRDINDALKELGRMCMTHLKSDKPQTKLGILNMAVDVIMSLEQQVRERNLNPKAACL 537 Hyalella azteca
OXU18495     222 ERRQANNARERIRIRDINEALKELGRMCMAHMKSEKPQTKLGILNMAVEVIMALEQQVRERNLNPKAACL 291 Trichomalopsis sarcophagae
XP_019770980 447 ERRQANNARERIRIRDINEALKELGRMCMAHLKTDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACL 516 mountain pine beetle

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