Conserved Protein Domain Family
Musclin

?
pfam11037: Musclin 
Insulin-resistance promoting peptide in skeletal muscle
Musclin is a muscle derived secretory peptide which induces insulin resistance in vitro. It encodes a 130 amino acid sequence including a NH(2) terminal 30 amino acid signal sequence. Musclin expression level is tightly regulated by nutritional changes.
Statistics
?
PSSM-Id: 463211
Aligned: 10 rows
Threshold Bit Score: 189.586
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
ABQ40394       1 MLQFQLVVVHLALVITLLQWHSSSVLLAEAAPEPLEPSAALGMAAHPTASEEKSASSLAAKLLLLDELVSLENEVTETKK 80 
XP_006637936   1 MLGCRCILLPCLFAVTLLHWSKGILQLAEGAPEFLDSSLVEAADSRSLSSDEKSSNDLAAKLLLLDELVNLENDVIETKK 80 
XP_005992527   1 MLECKLIFLHCLLAVTLLQWSGEKFLLAEGAPESFDSSMLSEID----SSEEKSSSDLTAKLLLLDELVSLENDVIETKR 76 
XP_001512349   1 MLESRLVIVHFIFAVILMPWSAGTALLVDAEPESFD-SVAEAMQSHSASSEEKSSTDLETKLLLLDELVSLENDVIETKK 79 
XP_012402138   1 MLDWRFVATHLILAIFLMQWSTGKGPGVEAAPEQAINSIAENAQSHIENTEEKSATELTQKLLFLDELVSLENDVIETKK 80 
XP_019695536   1 MLDGRLANAHFILAVTLMLWSSGKVRSMDVATEAFD-SGVIDVQSPPTVREEKSATNLAAKLLLLDELVSLENDVIETKK 79 
ABQ53647       1 MMDWRLASVHFILAVTLMLWSSGKVLSMDVTTKAFD-SELIDVEPPPTMTEEKSATDLAAKLLLLDELVSLENDVIETKK 79 
XP_004834833   1 MLDWGPAGAHFILAL-LVLWSSGKVLSVDATTEAFD-SVITDVQSPPTARREKSATDLAAKLLLLDELVSLENDVIETKK 78 
P61364         1 MLDWRLASTHFILAMIVMLWGSGKAFSVDLASQEFG---TASLQSPPTAREEKSATELSAKLLRLDDLVSLENDVFETKK 77  house mouse
XP_017949518  44 MLEWHCVSVSLLLAVSFVQWTSTEAAPAEPSTESLDTAVVLDGSSHSVSSEEKSAADLAAKILLLDELVSLENDVIETKK 123 tropical clawed...
ABQ40394      81 KRSFPGFGSPIDRISATSVDAKGKQRKVVELPKRRFGVPLDRIGVSRLGNTKG 133
XP_006637936  81 KRSFPGFGSPLDRLSVNNMELKGKQRKVVDLPRRRLNVPIDRIAMNRIPNSRG 133
XP_005992527  77 KRSFPGFGSPVDRLSVSSMDLKNKPRKVVEPPKRRFGVPIDRIGTNRLANSRG 129
XP_001512349  80 KRSFPGFGSPLDRLSAGSVDVKGKQRKVVELPKRRFGVPVDRIGANRLANTRG 132
XP_012402138  81 KRSFPVFGAPLDRLSAGSFNVKGKQRKTVDLPKRRFGVPIDRIGSNRLANTRG 133
XP_019695536  80 KRSFSGFGSPLDRLSAGSVDHKGKQRKVVDHPKRRFGIPVDRIGGNRLSNSRG 132
ABQ53647      80 KRSFSGFGSPLDRLSAGSPDHKGKQRKVVDHPKKRFGIPVDRIGRNRLPNSRG 132
XP_004834833  79 KRSFPGFGSPIDRLSAGSVDHKSKQRKAAHHSKRRFGIPVDRIGRNRLSNSRG 131
P61364        78 KRSFSGFGSPLDRLSAGSVEHRGKQRKAVDHSKKRFGIPMDRIGRNRLSSSRG 130 house mouse
XP_017949518 124 KRSFPGFGSPLDRLSAGTTEFKGKQRKVVELPKRRFGIPLDRIGMNRLANTRG 176 tropical clawed frog
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap