Conserved Protein Domain Family
Dynactin_p62

?
pfam05502: Dynactin_p62 
Dynactin p62 family
Dynactin is a multi-subunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein. p62 binds directly to the Arp1 subunit of dynactin.
Statistics
?
PSSM-Id: 428497
Aligned: 25 rows
Threshold Bit Score: 623.986
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
CAL00637      57 PPEQLLYCEDCHQIKCPRCITEEIVCWYCPNCLFETPSSMVRSEGNRCARNCFNCPICTAPLGVNTLENVVt-------- 128
XP_012738764  60 PIDHLLYCEICAQIRCQRCLADEIVTWFCPNCLFEVPSSTVKSEGNRCTRSCFQCPICIAPLSLTGQGASNtll-----g 134
EKG17112      57 PLEHLLYCEDCHQIRCPRCVSEEVITWFCPSCLFEVPSSNVRSDGNRCMRSCYNCPVCTAPMIVNSLDSENekharlgeg 136
EMD60577      53 PLEHLLYCEDCLQIRCPRCVIEETLNWYCPSCLFEVPSSVVKSDGNRCTRNCFNCPVCISPMIVNLLENPDvd------- 125
XP_003835083  56 PLEHLLYCEDCQQIRCPRCVIEETLNWYCPHCLFEVPSSVVKSDGNRCTRNCFNCPICISPLIVNVLDNPDrp------- 128
GAD96698      68 PPEQLLYCEDCHQIKCPRCITEEIVCWYCPNCLFETPSSMVRSEGNRCARNCFNCPICTAPLAVTTLEN-Ta-------- 138
XP_002374707  69 PPEQLLYCEDCHQIKCPRCITEEIVCWYCPNCLFETPSSMVRSEGNRCARNCFNCPICTAPLAVTTLEN-Vt-------- 139
Q4WXU4        68 PPEQLLYCEDCHQIKCPRCITEEIVCWYCPNCLFETPSSMVRSEGNRCARNCFNCPICTAPLAVNTLEN-Va-------- 138 Aspergillus fum...
EFW20355      61 PPEHLLYCEDCHQIKCPRCITEEIVCWYCPNCLFETPSSMVKSEGNRCTRNCFNCPICTSPLAVSTVGNGDg-------- 132
EEQ84309      66 PPEHLLYCEDCHQIKCPRCITEEIVCWYCPNCLFETPSSMVRSEGNRCARNCFNCPICTSPLSVTTLGSAD--------- 136
CAL00637     129 -gGTSQQGPWVLSCGYCMWSTLDIGIKFDKPTNIRTQLSKMTEitPARSRQMSRTFgdlK-------SPLSTYssidehf 200
XP_012738764 135 gaDSSH---WVLSCASCSWSSSEIGIQFDRPNGIYNQLSRIRN--GGQVITPPKERalgKdtdrrpgERRSTLskvsehd 209
EKG17112     137 geAVQPPGPFYLACPYCQWSTLEIGVEFEKPNNISGQLARLAN--GGKTVPTLRERekaR-------DRRKEAeesg--- 204
EMD60577     126 ---hsTTDRHILACPYCHWSTVETGIEFEKHTGVYSQISRIAN--GGKPIPSIKERdkeR-------ERRKELeaqrrds 193
XP_003835083 129 ---pgTGDRHILACPYCHWSTIETGIEFEKHTGVYAQISRIAN--GGKPIPTLKERdkeR-------ERRKDHearsret 196
GAD96698     139 -aGGSHQGPWVLACQYCMWTTLDIGIKFDKPTNIRTQLAKLTE--AAGGRKTARGIsdmK-------SPLASFssatdlp 208
XP_002374707 140 -gGGSQQGPWVLSCGYCMWTTLDIGVKFDKPTNIRTQLSKMTD--SSRGRQMSKTFsdlK-------SPLSTYssiddqf 209
Q4WXU4       139 -gSEGQQGPWVLSCAYCMWSSLDIGIKFDKPTNICTQLSKMTNttTARGRQMSKSVcelK-------SPLSTYstiddqf 210 Aspergillus fum...
EFW20355     133 -nGSSQNGPWILTCSYCMWTTLDIGIKFDKPTNIRSQLSSIFK--GTDRRESIARPshmR-------SPLSSFsslqdia 202
EEQ84309     137 --NGAQNGPWILSCGYCMWTTLDIGIKFDKPTNIRAQLTSLSN--GQN-----RSSpeiK-------SPLANLtspddgt 200
CAL00637     201 pppgenkpED---SPLDq--pSAPLTPDARFHALKNFYKNQISATSsSPTDPL-GMDFGSGFSSPGALNRIMSLYTSssr 274
XP_012738764 210 tpesdageEE-----------DTDPTPEARFASLRAFYQSQMSS---HGSTERsAFTNDYSYASPNALSRIMNLYTS--- 272
EKG17112     205 -----kkpDEe--EEVDihddHSPLDYDMRFSNLSAFYKSQLQTDTm-------GGGYGGDYGSSSTLSRIMSMYSG--- 267
EMD60577     194 -rnpqassRg---SAIVhaggYEPPSRDDLFANLAAFYKAELDAQ--TPSNPLe-----MNFSSPTAYSRIMNLYST--- 259
XP_003835083 197 -glpssptDDfmtNPAD----SEPLSREDLFSNLSAFYKSQLEAQ--APSNSLfAAGD-MNFSSPSAYTRIMNLYST--- 265
GAD96698     209 -amgesedEGk--EPRPmd-eQPPLDQDARFDALKSFYRNQIAETSsSPSDPL-GTDFGAGFSSPSALNRIMSLYTSstf 283
XP_002374707 210 pspsemrgDDa--SPANeq-sSGPLNPEARFQALKGFYKSQIASTSsLPNDPL--ADFGAGFSSPGALNRIMSLYTSssr 284
Q4WXU4       211 papgesrdGQs--TPSGdq-sAAPLTSDGRFSALKAFYKDQIAATStSPTDPL-GTDFGPGFASPGALNRIMSLYAAssr 286 Aspergillus fum...
EFW20355     203 -dgpspqdEHqtqGALSed-sQSSLNHDARFAALKSFYRSQLAETTsSP-DPLiGPELGS-YSSPSALSRIMSLYASglg 278
EEQ84309     201 --gldsqdERlagTAFSee-kPATIDPESRFSALKSFYRNQLTETStSPTDPLvGPELGGFYSSPSALNRIMSLYTAgig 277
CAL00637     275 lsslyGGANKKPKTKPPVMREALTASEGLK-IPSpDAEDTLIQRMSSPdcGWDGLASIEQRGFQSPDA---RFVEDLLPL 350
XP_012738764 273 ------YPSPTTQKRMTQVREALNTSEGLHpIPDpASEAATILRLRKE--GWAGTPSTEQRAAQPFPTcdiHSTSELRPS 344
EKG17112     268 ------GSKKLKKDRPSAMREAFGSDEGFQ-VHNaSSEEETIKRMRQV--GWEGTIAPDQRRSQTQDDi--RFAADLRPV 336
EMD60577     260 ------STKKSKRNKPTPMRDAASELEGLV-THDpAAENAAIERIKRG--GWSATLSPTQKLAQLDPHv--QFDDELRPI 328
XP_003835083 266 -----TTAKKQKRNKPSPMREAASELEGLA-IHDpASDIAAIERIKRD--GWASTLSTTQKLEQINPHi--RFEDELRPV 335
GAD96698     284 g-glyGAGGKKPKSKPPVMREALTASEGLK-IPSpDFEESVIHRMSSDecGWDGLASMEQRAFQAPDA---RFVEDLRPL 358
XP_002374707 285 lgnlyGGTNKKPKSKPPVMREALTTSEGLR-VPApDAENALIRRMASDdcGWDGMASIEQRTFQSPDA---RFVEDLLPL 360
Q4WXU4       287 lsslyGSANKKPKSKPPVMREALTASEGLK-VATpGAEDAIIQRISSEvcGWDGLASIEQRMFQSPDV---RFVEDLLPL 362 Aspergillus fum...
EFW20355     279 --glhGSGAKKAKSRPPVMREALTQSEGLH-IPPaGAESATVQKMATE--GWDGLASMEQRLFQLPGT---RFVDDLCPL 350
EEQ84309     278 --nlhGAGSKKPKSKPPVMREALTPAEGLH-IPDpNTEQAIIQKMASPdcGWDGLASVEQKVSQPPST---RFVDELRPL 351
CAL00637     351 PVLLRTKRSKRCKSCKHILVKPELKPQSTRFRIRLIALSYIPLPTLRPLNPSPSpattttttTVLP--TPSSSttnp--- 425
XP_012738764 345 PYLLRTKRTKRCRTCKHIVVRPEAKVQTSRFRMKMLAASYIPTFSIRPLPT-----------PSAPaaAAGATq------ 407
EKG17112     337 PTLLRTKRAKRCRTCRHILARPETKISSSRYKIKLLALNNIPQISLKALPRHSE--------TSTPsaPSVlpfd----- 403
EMD60577     329 PTLLCTKRSKRCRSCRHILAKPESKITSTRYKIKLLALNHIPRLSVRALPP-----------PSNPpvPAFPGsvpapap 397
XP_003835083 336 PTLLCTRRTKRCRSCRQIVAKPESKITSTRYKIKILALSHIPRISIRALP------------ATNPgqPSTSVqspai-- 401
GAD96698     359 PVQLRTKRSKRCKACKHILVKPEFKPQSTRFRIRLIALSYIPLPTLRPLTPTSH--------AGIP---LSPTvapp--- 424
XP_002374707 361 PVLLRTKRSKRCKSCKHILVKPEFKPQSTRFRIRLIALSYIPLPTLKPLVPSPF--------AGLP---SVTSgaap--- 426
Q4WXU4       363 PVLLRTKRSKRCKSCKHILVKPELKPQSTRFRIRLIALSYIPLPTLRPLALGPP--------TGLPaiTPSASssap--- 431 Aspergillus fum...
EFW20355     351 PAFLRTKRSKRCKACKHILVKPEFKPQSTRFRIRLIAISYIPLTNLRPIVPLP---------PTPPvnl----------- 410
EEQ84309     352 PVLLRTKRSKRCKACKHILVKPEFKPQSTRFRIRLIALSYIPLTIMRPLPPFPA--------SSPPvnl----------- 412
CAL00637     426 -----------nldaLSPLRPIQLLLTLKNHMFDPVRVTLATPSVTPGRVASKVTILCPQFDIGAN----SDVWDEALQg 490
XP_012738764 408 --------------lLQPGTTHQFVLTVRNPLYERVRVTLAAAAKTPGRVAHGVTLLCPQFEVGASreayADMLDEALS- 472
EKG17112     404 ------------ynkLQPFMANHFILTIRNPLFDPIRVTLATPAITPGRIASKVTVLCPEFEVGAN----TDVWDEALTg 467
EMD60577     398 qsaqpqpqlpfnynaLRPGIPAHFLLHLSNPLFDPIRVTLATSSTTPGRVSSRVTILCPEFEVGAN----TDVWDDALS- 472
XP_003835083 402 -----------nytaLRSGVATHFLLTLSNPLFDPIRVTLATSSLTPGKVQSRVTILCPQFDIGKN----TDVWDDALS- 465
GAD96698     425 -----------dldaLPPLRPIQYLLTLKNHMFDPVRATLATPSLTPGRVATKVTILCPQFDIGAN----SDVWDEALQ- 488
XP_002374707 427 -----------nldaLSPLKTVQLQLTLKNHMFDPVRVTLATPSVTPGRVASKVTILCPQFDIGAN----SDVWDEALQg 491
Q4WXU4       432 -----------nldaLPPLKPFQLLLTLKNHMFDPVRVTLATPSVTPGRVATKVTILCPQFDIGAN----SDVWDEALQg 496 Aspergillus fum...
EFW20355     411 -------------daLEPLKPVQLLLTLKNHMFDPIRVTLATPSVTPGRVASRVTILCPEFEVGAN----TDVWDEALQ- 472
EEQ84309     413 -------------daLEPGRPVQFLITLKNHMFDPIRITLATPSVTPGRVESKVTMLCPQFEVGAN----SDVWDEALA- 474
CAL00637     491 tsatttttaAAGTgtdpRGSRSGglg-vyEKVAEAGKVWDKGRNWTTVVLEVVPGTLp---gDSDPNQQLQPDE 560
XP_012738764 473 ------------------GGEANa----gTGEGEAGKVYERARNAVGVVVEVVPGV---------EEGFRDARS 515
EKG17112     468 s------gaTQRKsqppSSIELGas--npATQAEAGKVWERGRNWTSVILEVVPDKAdp----aDLEGGLDEDE 529
EMD60577     473 ----------SSPapmpRRSTINa----eTGQIEAGKIWDKGRNWTSVAIEVIPGFLde---vNGEEEELEPDD 529
XP_003835083 466 ----------STVaperRGSLLNa-----DGQIEAGKVWDKGRNWTTVAIEVVPGFLkpttgFGSVEEELDEDD 524
GAD96698     489 ----------ASTaa-dRSSRAAlagfgtEKVAEAGKVWDKGRNWTTVVLEIVPGTLp---gEGDKSDdnnnrh 548
XP_002374707 492 s----------tApgdaRASRSGtlg-stEKVAEAGKVWDKGRNWTTVVLEVVPGTLpg--gGATGRNRMKQHY 552
Q4WXU4       497 t----------tTggdnRSSRSGgmnlgyEKVAEAGKVWDKGRNWTTVVLEVVPGTLp---gGSLGTRRRQSLG 557 Aspergillus fumigatus
EFW20355     473 ----------SSSapdpRSSRSGv-----EKVAEAGKVWDKGRNWSTVAMEVVPGSL-----ADLGESGLTEDE 526
EEQ84309     475 ----------SSAaqdpRSSRSGl-----DKVAEAGKIWDKGRNWTTVAMEVVPGSL-----PDLAPGEEDEDE 528
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap