1AYA,3EAC,3GQI,2PTK,1GRI,1RJA,2EYZ,3GQI,2ECD,1M61,1TCE,1H9O,2CS0,1A81,1MW4,1M61,1X6C,2YSX,3CD3,2CIA,1A81,2DLZ,2IUG,2KNO,2GE9,2C9W,1KA6,1RQQ,2EO6,3PJP,3PSK,3MAZ,1XA6,2CR4,1Y1U,3PFV,3PSK,3PJP,3QWX


Conserved Protein Domain Family
SH2
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cd00173: SH2 
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Src homology 2 (SH2) domain
In general, SH2 domains are involved in signal transduction; they bind pTyr-containing polypeptide ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites. They are present in a wide array of proteins including: adaptor proteins (Nck1, Crk, Grb2), scaffolds (Slp76, Shc, Dapp1), kinases (Src, Syk, Fps, Tec), phosphatases (Shp-1, Shp-2), transcription factors (STAT1), Ras signaling molecules (Ras-Gap), ubiquitination factors (c-Cbl), cytoskeleton regulators (Tensin), signal regulators (SAP), and phospholipid second messengers (PLCgamma), amongst others.
Links
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Statistics
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PSSM-Id: 198173
Aligned: 351 rows
Threshold Bit Score: 35.5091
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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phosphotyrosinehydrophobic
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:phosphotyrosine binding pocket [polypeptide binding site]
Evidence:
  • Structure:1AYA: The SH2 domain of mouse Syp tyrosine phosphatase binds a phosphotyrosine-containing peptide fragment of PDGFR, contacts at 4 A
  • Citation:PMID 7521735
  • Structure:3GQI: An SH2 domain of rat phospholipase C-gamma-1 binds the C-terminal phosphorylated tail of the basic fibroblast growth factor receptor 1, contacts at 4 A
  • Comment:conserved Arg forms critical H-bonds with phosphate oxygens of pTyr side chain
  • Citation:PMID 9817027
  • Citation:PMID 8181064
  • Citation:PMID 8604142
  • Citation:PMID 7521735
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                         #                                  # #       
1AYA_A       3 RWFHPNi-tGVEAENLLltr-------gvDGSFLARPSks---------npGDFTLSVRrn-----gaVTHIKIQNtgdy 60   house mouse
3MAZ_A      17 ACFYTVs--RKEATEMLqkn-------psLGNMILRPGsd----------sRNYSITIRqeid--iprIKHYKVMSvgqn 75   human
3PSK_A     112 SSEKFKsgtKKDVVKFIedysr---vnpnKSVYYFSLNhd---------npGWFYLMFKina---nskLYTWNVKLtntg 176  baker's yeast
3PJP_A     106 SNEKFKagtKKEVVKFIedysk---vnpkKSVYYFSLNye---------npGWFYLIFKlna---eskLYIWNVKLthtg 170  Candida glabrata
EGD77471    20 FWLSVDi-pRQLAEKSLttph-----lapTGSFILRRSks---------spGNYAVTVVqg-----ktIKSYEIMDlgmg 79   Salpingoeca sp. ...
EGD78242    23 SRLHPAa-aATQPQQRQfsrpqh-qlaqtDGEFELRPHsd----------gRWFALNISygs----gtITRIIEKSpegf 86   Salpingoeca sp. ...
Q8VHX6    1192 EILSDA---GVKAEVLIqn--------naDGTYHITYSpa---------fpGTYTITIKygghpipkfPTRVHVQPavdt 1251 house mouse
EFW39647    13 EGNHTAl--SQKPPKPVgsngisspstspNSSNVAVPDlsgpk---gtsslGDYVLSVSes-----grASHYIVAArgns 82   Capsaspora owcza...
EFA84528   208 SWKDFY---RYWATEYLk----------yTGWYHYSLTreeataklqnmakGTFLIRKSskp---snlVISYNVHSkkpq 271  Polysphondylium ...
EDP35640   204 PYFHDEp-iNVLTQRLTqy---------tDGCYLLRHSfv---------qsSSYTLMVNid-----qhIEKFQIKRtadg 259  agent of lymphat...

Feature 1                             
1AYA_A      61 ydlyg----gekfatlaELVQYY 79   house mouse
3MAZ_A      76 ytiele--kpvtlpnlfSVIDYF 96   human
3PSK_A     177 yflv-----nynypsviQLCNGF 194  baker's yeast
3PJP_A     171 fflv-----nynyptviQLCNGF 188  Candida glabrata
EGD77471    80 qiglg---tgqafesleTMLDFF 99   Salpingoeca sp. ATCC50818
EGD78242    87 mvlgsq--skrafptlaALIEHY 107  Salpingoeca sp. ATCC50818
Q8VHX6    1252 sgikvsgpgvephgvlrEVTTEF 1274 house mouse
EFW39647    83 yiig-----dqqfrdlpHVIEFY 100  Capsaspora owczarzaki ATCC 30864
EFA84528   272 hlllydlgphvgvflndEMGKIY 294  Polysphondylium pallidum PN500
EDP35640   260 nfeid----gqifatipDIIERY 278  agent of lymphatic filariasis

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