Conserved Protein Domain Family
Adaptin_binding

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pfam10199: Adaptin_binding 
Alpha and gamma adaptin binding protein p34
p34 is a protein involved in membrane trafficking. It is known to interact with both alpha and gamma adaptin. It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane.
Statistics
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PSSM-Id: 462994
Aligned: 27 rows
Threshold Bit Score: 48.6566
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011388736 277 DKDGIE--RIREALMNHMWNGLirkdqtaslsnrnasletgpalfassdahpsfsdsavgrfkgdeedtdpaeaiqdsae 354
XP_001323164 135 EEQQPAgtRIMESLELVDWPIK---------------------------------------------------------- 156
A0C1I4       172 ETLGFP--RIIEIMECNTWTYMrpk------------------------------------------------------- 194 Paramecium tetr...
Q22XW2       202 ETDGIA--RIIDILESNVWTDSemfkvekkqnleqqhtklnihiptyeknkdirekyek--------------------- 258 Tetrahymena the...
XP_001613715 275 EQEDDE--RLVEALHCHMWKGLqikrdhliiqhrgdfpmg---------------------------------------- 312
A5DMM1       176 DKLGID--RLVELFDTHDWSDIetse------------------------------------------------------ 199 Meyerozyma guil...
XP_001524423 218 EKQGKE--RVREVMESHDWPNIdpasfpnvqds----------------------------------------------- 248
Q6FWX8       184 ECKGMA--RLKEIIDTHPWTDCk--------------------------------------------------------- 204 Nakaseomyces gl...
Q6BHQ2       183 DKIGQD--RLLEIIETHEWSQMdlkq------------------------------------------------------ 206 Debaryomyces ha...
XP_001383879 144 EKIGTD--RLVELIETHEWTHMdl-------------------------------------------------------- 165
XP_011388736 355 salepsslrhhlatigdsfsdntgfpmldsnahadasdldeqlaklflsandgaraadlAQLEAFLESQDPSWPASTPPP 434
XP_001323164 157 -----------------------------------------------------------MSAGKPRMEQRIEQMVALLKS 177
A0C1I4       195 --------------------------------------------------------sqeKKENTGKTKVSEKQTQGLDQL 218 Paramecium tetr...
Q22XW2       259 ----------------------ygnnnddeeeeeinlekqnnilkvnkneeiekqelkdKKQEVKEVNSNQEQKQQMEID 316 Tetrahymena the...
XP_001613715 313 ------------------------------------------eafkgdeaarkgektpqKDEASPNGEKTPQKDEAAPNG 350
A5DMM1       200 --------------------------------------------------------ddgFAARKRKMAESMCQRLLDDDE 223 Meyerozyma guil...
XP_001524423 249 ------------------------------------------------kmkeernrakiKALEDPLVKKQPQQEDLRVEE 280
Q6FWX8       205 ----------------------------------------------------------vVLKNKESTSDKVNKP------ 220 Nakaseomyces gl...
Q6BHQ2       207 -------------------------------------------------------grdqDAYDETKRNKMSDMTKGLLDG 231 Debaryomyces ha...
XP_001383879     --------------------------------------------------------------------------------    
XP_011388736 435 KSaadpesadarfdddfddflpfqsalsdatqstsqnasadvddlptmddisqmqnhlfgglaaARIEanppgaatrsns 514
XP_001323164 178 ND--------------------------------------------------------------PECE------------ 183
A0C1I4       219 E---------------------------------------------------------------FEDD------------ 223 Paramecium tetr...
Q22XW2       317 NKkqeeqqlskeneqlnnndtnkninsnqipeqkednktkeqeenkskdsknkqnkqnikydndDDEEiqen-------- 388 Tetrahymena the...
XP_001613715 351 ENppqrdapatsgaakidl----------------------------sgtlansaktpegqkeeLFME------------ 390
A5DMM1       224 KDmssen-----------------------------------------------------gvndVNVE------------ 238 Meyerozyma guil...
XP_001524423 281 NEneeenelyanrevynndndky---------------------ddqnddknddkndnkndnsnNNED------------ 327
Q6FWX8           --------------------------------------------------------------------------------     Nakaseomyces gl...
Q6BHQ2       232 QDeqegdd---------------------------------------------------gdetqSKLI------------ 248 Debaryomyces ha...
XP_001383879     --------------------------------------------------------------------------------    
XP_011388736 515 tygDLASQLQQLQMHAQRVRN--ITDa-----DQRRKEAALVALA 552
XP_001323164 184 ---NFDQALSIMMELKDQIPK--LPD------AERHKYAAAVALA 217
A0C1I4       224 ---QFAQLMHDMTKIRTSK----MTD------EERREKAANLMNQ 255 Paramecium tetraurelia
Q22XW2       389 tlnDFVKILSQMKGLKDNSQQ--LPD------EKRKENAEKFILN 425 Tetrahymena thermophila SB210
XP_001613715 391 ---NFNKIVEKIRVAKMENKN--CSNh-----AARRKKAEEIIFE 425
A5DMM1       239 ---EFENVIEKLKQARIKAES--MEG------AERNEYAQQVMED 272 Meyerozyma guilliermondii ATCC 6260
XP_001524423 328 ---NLEYLLTRLVLARQKAET--LSG------EERERYAAECVDD 361
Q6FWX8       221 ---DLEYLIDTLKKAKIHYQK--LSNgsdgfsEEAEQFALQMATD 260 Nakaseomyces glabratus CBS 138
Q6BHQ2       249 ---DLDDVLTKVQQAKQNVNNndMDD------AQKEAYVNKVVKD 284 Debaryomyces hansenii
XP_001383879 166 --vSVNYQTNKTNRAKEMTKG--LLD----------------VEE 190
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