Conserved Protein Domain Family
CD34_antigen

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pfam06365: CD34_antigen 
CD34/Podocalyxin family
This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.
Statistics
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PSSM-Id: 461884
Aligned: 15 rows
Threshold Bit Score: 157.215
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_017740628 329 ILNMTENIDCEVFRQHRGPQLLALVEEVLPRHgsGHHGAWHISLSKPSEKEQHLLMTLVGEQgvvPTQDVLSMLGDIRRS 408
Q28270       196 CLELNETSSCEDFKKDNEEKLTQVLCEKEPAE--AGAGVCSLLLAQSEVRPHCLLLVLANKT---ELFSKLQLLRKHQSD 270 dog
XP_015203509 346 ILNMSENVDCDTFRVESGDRLLEMLESAFSRKmnSPQGSWFISLTKPNRQDKQLLMTLASEQgviPTKEVLSMLGEIRRS 425
XP_005992594 352 ILNVSHNMDCEDFRLQNGARFLSLVGRAFSRRteRPQESWRILLSKPNEDDSRLLMTLTGEQgviPVKDLLAAMRDINRD 431
XP_019475522 442 ILNMSDNIDCEEFRLERGPQLLALVEDAFSRHadGLQDHWMISLSKPNENDKHLLMTLAGEQgviPTKDVLMALGDVKRS 521
NP_001258823 373 ILNLKEEKTCDDWKKASNEAFFEVFCSGRRHAfnSTRDRCTVKLAS--SNHRRWAVHVIVHRv-lDPAAVFEELKEKRNE 449
XP_007504399 391 ILKMTNFTMCDSPKDSRNHPLYVALCRAGKVNfnKDRDVCHVQLVPQPEKQEVAILNVSVQTh-lQPKELFEVLKKRWDD 469
XP_021586049 355 ILNLTETSPCAKSP-PADDKLITQLCQAVKATfnPAQDSCTVQLAPIQESQAVALKKITIQTn-lLPENVYALLKDKWDD 432
XP_010588581 193 CLEQNETSRCEDFKKDKGEDLVQILCDEKEQ---AGAEVCSLLLAQSEIKPQCLMLFLPNRT---ELPSKLQFMEKHRFD 266
XP_003474706 195 CLELNKTSSCEDFKKNTGEDLIQILCGKEEAEptAGTATCSLLLAQSEVQPQCLLLVFANST---ELSGKISLLKKHKSD 271
XP_017740628 409 LEEIGIQNYSttsscqARASQVRSDYGTLFVVLVVIGAICIIIIALGLLYncWQRRLPKLKHVSH-GEELRFVENGChDN 487
Q28270       271 LKKLGIRDFT------EQDVGSHQSYSRKTLIALVTSGILLAVLGTTGYF--LMNRRSWSPTGERlGEDPYYTENGG-GQ 341 dog
XP_015203509 426 LYEIGIQNYTsvtscqSQPSQTRSDYGKLFVVLVIIGSVCVVIIVSGLIYicWQRRLPKLKNMSH-GEELHFVENGChDN 504
XP_005992594 432 LQEVGIQNFTaaaacqSKVNPSRSDYGKLFVVLVIIGSICVIIIVVGLVYicWQRRLPKLKAMSH-GEELHFVENGChDN 510
XP_019475522 522 LAEIGIQNYStttscqSHPNQTRSDYGKLFVVLVIIGSICAIIIVLGLIYncWQRRLPKMKNMSH-GEELRFVENGChDN 600
NP_001258823 450 LEKLGITNVTylnqemEEE--IKDQFSTPLIITIVT--LAGSLLLIAAIYgcCHQRFSQKKSQQRlTEELQTMENGYhDN 525
XP_007504399 470 LKALGVSNMTygkeslDKD--EEDRFSLPLIITIVC--MAAFLLLVAALYgcFHQRFSQRKDQQRlTEELQTVENGYhDN 545
XP_021586049 433 LREVGVSHMQlgdegpPEE--AEDRFSMPLIITIVC--MASFLLLVAALYgcCHQRLSQRKDQQRlTEELQTVENGYhDN 508
XP_010588581 267 LQKLGIRDFT------EENVLSHQSHSRKTLIAVVTSGILLAILGTTGYF--LMNRRSWNPAGERlGEEPYHSESGG-GQ 337
XP_003474706 272 LEKLGIHSFR------EQDIGSHQSYSRKTLIAVVTSGILLAILGTTGYF--LMNRRSWSPAGERlGEDPYCTENSG-GQ 342
XP_017740628 488 PtLDVASDSQSEMQEKhPSLNGGGALNGP--GSWGalmgGKRDPEDSDVFEEDTHL 541
Q28270       342 G-YSSGPGVSPEAQGK-ASVNRGPQENGT--GQAT----SRNGHSARQHMVADTEL 389 dog
XP_015203509 505 PtLDVASDSQSEMQEKkPSVNGV-AVDGG--GSWHvl-vNKSAKEDAENLEEDTHL 556
XP_005992594 511 PtLDVTIDSQSEMQEKqQSVNGG-ALDGP--DSWSvl-vNRRAVDEAETLEEDTHL 562
XP_019475522 601 PtLDVASDSQSEMQEKkPSVNGGNTINGP--DSWDvl-iNKQASEDVDVFEEDTHL 653
NP_001258823 526 PtLEVME-TGSEMQEK------KVNLNGElgDSWIvp-lDTIMKEDLE--EEDTHL 571
XP_007504399 546 PtLEVME-TSSEMQEK-----KVANLNGElgDSWIvp-lDNLTKDDLDQEEEDTHL 594
XP_021586049 509 PtLEVME-TSSEMQEK-----KVVNLNGElgDSWIvp-lDNLTKDDLD--EEDTHL 555
XP_010588581 338 G-YSSSPGASPEAQGK-AIVNQGAQENGT--GQAT----SRNGHSARQHVVADTEL 385
XP_003474706 343 G-YSSGPGASSEAQGK-ASVNRGAQENGT--GQAT----SRNGHSARQH-VADTEL 389
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