Conserved Protein Domain Family
7tmA_OR8K-like

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cd15413: 7tmA_OR8K-like 
olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320535
Aligned: 17 rows
Threshold Bit Score: 440.605
Created: 17-Jan-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q8NH51        25 APLFALFLMIYVISVMGNLGMIVLTKLDSRLQTPMYFFLRHLAFMDLGYSTTVGPKMLVNFVVDKNIISYYFCATQLAFF 104 human
NP_001000680  29 VPLFGLFLIIYLTSLVGNLGMIILTMMDCRLQTPMYFFLRHLATTDLGYSTAVGPKMLSNFLVDQNTISFQDCAIQSAFF 108 Norway rat
XP_007519593  25 TPLFVLFLFMYMTSLMANLGLVILTRMDAKLQTPMYFFLRHLALMDFGCSTTVSPKMLVNFVVGQNKISFCLCALQLSLF 104 western Europea...
XP_007664801  25 IPLFIVLLLIYCTTVLGNLGLIFLTRTDSRLQTPMYFFLGHLALVDVGYSTAVGPQMLVNLFEERKSISFCLCTVQLCCF 104 platypus
XP_006117008  25 VPLFLLFLVIYVVTLIGNIGMIILIIVDHRLHTPMYFFLSHLAFVDLCYSSTVTPKMLVNFLAESKTISYYACATQLGCF 104 Chinese soft-sh...
XP_007664803  25 AVLFVLFLPIYVLSVTGNLGLIGLIGLSPRLHTPMYFFLSHLAFVDFCYTSSITPNMLVDLVVELKSISFLACAIQVCCF 104 platypus
NP_001000303  25 IILFMLILVVYSLTLIGNVGMISLIRMDSRLHTPMYFFLSNLAFVDLCYSSSVAPKFLEILLSNKRSISFYACATQLGFF 104 Norway rat
Q8NH85        25 APCFGVFLVIYLVTVLGNLGLITLIKIDTRLHTPMYYFLSHLAFVDLCYSSAITPKMMVNFVVERNTIPFHACATQLGCF 104 human
Q8NH10        25 MPLFVLFLSIYLFTVVGNLGLILLIRADTSLNTPMYFFLSNLAFVDFCYSSVITPKMLGNFLYKQNVISFDACATQLGCF 104 human
Q8NGG0        25 IPLFLVFLVLYVLTMAGNLGIITLTSVDSRLQNPMYFFLRHLAIINLGNSTVIAPKMLMNFLVKKKTTSFYECATQLGGF 104 human
Feature 1        #  #                                            # #####                         
Q8NH51       105 LVFIGSELFILSAMSYDLYVAICNPLLYTVIMsRRVCQVLVAIPYLYCTFISLLVTIKIFTLSFCGYNVISHFYCDSLPL 184 human
NP_001000680 109 SMFIVSEFFILSAMFYDHYVAICKPLLYTIIVsQKVCWILVTIPYLYSIIVSLLVNIKIFTLSFCGYNVINHFYCDALPL 188 Norway rat
XP_007519593 105 SFFIANEFFILSAMSYDRYVAICNPLLYAAIMsPRLCQVLTAIPYIYSTVVSLTITFEIFNQPFCGGNVIRHFYCDSVPL 184 western Europea...
XP_007664801 105 ITFIITELFLLSAMAYDRYVAICNPLLYKLIIsKKVCILLVTIPYIYSLTVALFTVVFTFRSSFCGNNVIDHFYCDSLPI 184 platypus
XP_006117008 105 LTFMITECFLLAGMAYDRYVAICNPLLYKVIMsQKVCVQLVAGPYIYSFCVALFHTILTFRLSFCSSNMINHFYCDDMPL 184 Chinese soft-sh...
XP_007664803 105 ITFINVEIFLLALMAYDRYVAICHPLLYTTVMsWKLCTQLVAGTYLYCFLVGFFHTFLTFRFSYCDSNVINHFYCDEVPL 184 platypus
NP_001000303 105 LNFLISEMFLLAVMAYDRYVAICNPLLYMVIMsQKVCLRLVVGPYFYSFAVALLHTVVTFKLIYCGPNIINHFYCDDVPL 184 Norway rat
Q8NH85       105 LTFMITECFLLASMAYDCYVAICSPLHYSTLMsRRVCIQLVAVPYIYSFLVALFHTVITFRLTYCGPNLINHFYCDDLPF 184 human
Q8NH10       105 LTFMISESLLLASMAYDRYVAICNPLLYMVVMtPGICIQLVAVPYSYSFLMALFHTILTFRLSYCHSNIVNHFYCDDMPL 184 human
Q8NGG0       105 LFFIVSEVMMLAVMAYDRYVAICNPLLYMVVVsRRLCLLLVSLTYLYGFSTAIVVSPCIFSVSYCSSNIINHFYCDIAPL 184 human
Feature 1                  #  ### ### ##                                            #  ## ##  #  
Q8NH51       185 LPLLCSNTHEIELIILIFAAIDLISSLLIVLLSYLLILVAILRMNS-AGRQKAFSTCGAHLTVVIVFYGTLLFMYVQPKS 263 human
NP_001000680 189 LSLACSNTHEIEVIILVFSAFNLLLSLLKVIGSYLLILKAILSINSaEGKRKAFSTCGSHLTVVIVFYGTLIFMYLQPAS 268 Norway rat
XP_007519593 185 ISLFCSGRREIEMIIMIFGSFNLLCSVPIVLVSYLFISVAILRMKSaEGRRKAFSTCGSHLTVVTLFYGTLIFMYLKPNS 264 western Europea...
XP_007664801 185 LALSCSDTRVVEYFILGDSTFNLIFSLLVVLVSYIFIISNILKIRSaQGRCKVFSTCGSHLMGVTVFYGTLIFMYMRPQA 264 platypus
XP_006117008 185 LALSCSNTYLKQVLIFAFAGFDMIASSLIVLISYLFIFSTILRIRSaEGRHKAFSTCASHITAVTIFYGTLIYMYLQPSS 264 Chinese soft-sh...
XP_007664803 185 LALSCSDTRIKERLIFAFAGFNTLGSLLIVLISYIFILLAILRIRSsEGRYKAFSTCASHLTSVTIFYGTIIFMYLQPKS 264 platypus
NP_001000303 185 MALACSDTSLKEILIFIFAGFNMISSLTTVLISYLYIVAAILRIRStEGRYKAFSTCASHLTAVTIFYGTLIFMYLQPKS 264 Norway rat
Q8NH85       185 LALSCSDTHMKEILIFAFAGFDMISSSSIVLTSYIFIIAAILRIRStQGQHKAISTCGSHMVTVTIFYGTLIFMYLQPKS 264 human
Q8NH10       185 LRLTCSDTRFKQLWIFACAGIMFISSLLIVFVSYMFIISAILRMHSaEGRQKAFSTCGSHMLAVTIFYGTLIFMYLQPSS 264 human
Q8NGG0       185 LALSCSDTYIPETIVFISAATNLVFSMITVLVSYFNIVLSILRIRSpEGRKKAFSTCASHMIAVTVFYGTMLFMYLQPQT 264 human
Feature 1           ## ###  #  ##                       
Q8NH51       264 SHSFDTDKVASIFYTLVIPMLNPLIYSLRNKDVKYALRR 302 human
NP_001000680 269 THSIDSNKVTSIFYTQVIPMLNPLIYSLRNKDVKDALKK 307 Norway rat
XP_007519593 265 SHSLETDKVTSIFYTLIIPVLNPLIYSLRNKDVKHALQR 303 western European hedgehog
XP_007664801 265 SHSFETDKMASLFYTQVIPMLNPLIYSLRNREVKEALER 303 platypus
XP_006117008 265 NHSLDTDKVASVFYTVVIPMLNPLIYSLRNREVKDALRK 303 Chinese soft-shelled turtle
XP_007664803 265 NHSLDTDKIASVFYTIVIPMLNPLIYSLRNQEVKGALKK 303 platypus
NP_001000303 265 SHSLDTDKMASVFYTIVIPMLNPMIYSLRNQEVKSALRK 303 Norway rat
Q8NH85       265 NHSLDTDKMASVFYTVVIPMLNPLIYSLRNKEVKDASKK 303 human
Q8NH10       265 SHALDTDKMASVFYTVIIPMLNPLIYSLQNKEVKEALKK 303 human
Q8NGG0       265 NHSLDTDKMASVFYTLVIPMLNPLIYSLRNNDVNVALKK 303 human

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