6ZYY,6ZYW,7KZN,6ZYW


Conserved Protein Domain Family
DHC_N2

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pfam08393: DHC_N2 
Dynein heavy chain, N-terminal region 2
Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Statistics
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PSSM-Id: 462462
Aligned: 523 rows
Threshold Bit Score: 66.8988
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6ZYY_C       1283 LEK--TDAEiknlnklynlydsvikniqqFKEKSWQD-VskdDLAKMEEDA---GKYG-EQC---S---------Rlpkd 1343 Tetrahymena t...
EAY20035      835 LSN--IKSDfdmllpawsiaveidttaqdWFGTIFKQ-L---DVQMISDTV---VEWE-NTL---KklmedieaaKnqdr 901 
EGD80062     1651 adT--ILEQidlltdcwqrmrewdarfeqWMPLPLAQ-L---DLEEMNAFV---SSFL-NAL---Thaqhtls------- 1710
XP_021335614   76 VGV--AQQRiearkglwelismsstqiqeWKLLHFRK-F---VVTKAQDVV---GSWIqKAEtfaK---------Vipf- 136 
Q57VL9        750 LRVfdvleqfwcsvfds-----------trvkdyyiiplsalNSEKTIDEVqrcRRLLhSSV---R---------Nlrg- 805  Trypanosoma b...
CAM41666      445 MNHfeiieqfwitvfes-----------tklrelyrtpvssvNANAFIERArewRRLIhSTIrnlRgy------------ 501 
Q4QIP4        778 MTHfetieqfwitvfes-----------tklrelyrtpvssvNASGFVERArewRRLIhSSIrnlRay------------ 834  Leishmania major
XP_001318628  692 FDEtkLFEGrrlsnclmklwvstkeysmenekiagTQ-IgliDTEEISKKF---EKWVgS-Indacdg------------ 754 
XP_002110236  958 LTA--ILKNidirqemwkyievsegrirdWMNTSFYK-L---DVTKLIHKV---NEWKnASVqlrN---------Qlpi- 1018
XP_027323346 2998 LEN--VGEEldpslepl-----------llkqtfkqGgV---DCIRLGEMV---IEYS-SDF---K---------Ffitt 3045 mallard
6ZYY_C       1344 l---------kewqAYRDLKNYIDslre----qlpLIISL-KKPSImPRHWEKIKEitntkl---nyenpdQF-YIEEIM 1405 Tetrahymena t...
EAY20035      902 hkkflregvhpleaPYKELQARVQyilm----hipIIRYI-CNPNYrQRHWKQISEtagfq------igpnDDyTWNWLI 970 
EGD80062     1711 -------ttfakiaTYTNKAADASll-------ldISEMV-RSPWFgQRYVRRTSVlvvln-------idvnItTYGYLH 1768
XP_021335614  137 -----------hdaLLQKNLQILQafnq----flsVLSKL-ISPTLkHKHWRNISKaigla------ydpeWKlTVADLL 194 
Q57VL9        806 ------------ypGLVCLGRQQEqvladfeslqtLLAYL-STPGLrKNHWKEIGRilqlgrk--qstqidSNvTLKQLL 870  Trypanosoma b...
CAM41666      502 -------------pALVRLGREQElalak-feeleLFLELiTTPGLrKSHWRDIAKlistqlrddillvtnMTvTVKRLL 567 
Q4QIP4        835 -------------pALVHLGREQElalak-feeleLFLELiTTPGLrKSHWRDIAKlisvqlrddvmlvtnMTvTVKRLL 900  Leishmania major
XP_001318628  755 ---------lkefqIPRNIAILVEsnvkefksyipIINAL-SSIYLrNRHWTMINDlfkld------hpldQSaTLYYLI 818 
XP_002110236 1019 -----------gdrVLDYWKKSLVdier----htpFLAKL-STKSLkARHWKDIFIgigqp------ydstWLfTTKELL 1076
XP_027323346 3046 k--------lrnphYLPELSTKVS-----------LLNFMiTPEGLe----DQLLGivvak------------------e 3084 mallard
6ZYY_C       1406 GAKLldfredIEDITESADKqLKIRTGLDEINLYWNDmq--fQFGI-WGKR--------------------Dv------- 1455 Tetrahymena t...
EAY20035      971 EFGVeqhiiaIASISKAATNeAKIEIAIAQMCDDLQKlr--fKVTK-TEHGihld------------------------- 1022
EGD80062     1769 ASKPpqrveaLEDLFVQAEEeQRREQQWKELNEKWDSmv--lPIKR-Qg------------------------------- 1814
XP_021335614  195 SKDLqrhqnkINKICLDSKAeTDMEQMFRALQRQWETae--fHHKR-F--Iiavqqqqtp--qlgdvlpqnApkhhisdg 267 
Q57VL9        871 ENGIidhldeIKLIVDPAFLdFEAEATLERMKSDAKKtrfvfEVAEgSNDAlils------------------------- 925  Trypanosoma b...
CAM41666      568 DAGLldhivpLAQIVSQARCdYDVENELEEMRSYAKRth--fALENsAVHD--------------------Dl------- 618 
Q4QIP4        901 DAGLldhivpLAQIVSQARCdYEVENELEEMRSYAKRth--lVLENtAAKN--------------------Dl------- 951  Leishmania major
XP_001318628  819 DIIVlnkekeIMDIVKIAENeYILEDFLDGIIASFYDwtfsitl------------------------------------ 862 
XP_002110236 1077 SFDLelhtslINSVVARADAeFALEGSFQQICKVWEDkk--lQLTK-HIPIvqvsnvnqtpmstdsnvneiAkqdsrmdd 1153
XP_027323346 3085 rpeLee--erNILILQSAANkKNLKEIERKILETLQSse--gNILE-D-------------------------------- 3127 mallard
6ZYY_C       1456 -PcmlngliVGTILER--L-------EEDQ-------LQLSTFNSQRHV-TpF-KAEVENLIRTFSDVNDTLDMWVKVQK 1516 Tetrahymena t...
EAY20035     1023 ------dpaTALL-----LlakhqqiMQEIfvppyiqPFISKVKEYELL-----AANTRQILKQSIETEERINELQPAME 1086
EGD80062     1815 ---------STLLGRDayLlenvsalRDEIvhaemvlLNLSRSDASPEL-----KSKARALHEKITTFEQRLSQWEDCER 1880
XP_021335614  268 gTfti--tgIETLLAH--S-------KESV-------LILSDMLRSPYVdE-F-QKDVEHWLLFLQELDELLDIFERYQQ 327 
Q57VL9        926 ------prcRTSISSQ--L-------EAFS-------HELSALRQVEHLsQ-YtISSVMEFDSVVQRMKETLLTWEDVEK 982  Trypanosoma b...
CAM41666      619 -NtpplkgnRHEMVCR--I-------EECM-------LKCRAMRRRPNLgP-SvLRAVDEWVDACEKSREVLLAWDNVKM 680 
Q4QIP4        952 -SalllqepQREMMYR--I-------EEYV-------LKCRAMRRRPNLgP-SvLKSLDEWVDACEKSRGVLLAWDQVKG 1013 Leishmania major
XP_001318628  863 ---fncsnfIKEGISR--L-------QDQM-------RDLRKVKKSNFKnL-F-LQKIEKHENFVTQMQDFVTLLRKIYN 921 
XP_002110236 1154 dAlvl--mgVEELKVQ--L-------EDHQ-------ITLRGMLVSSHLaD-L-RYQVEAWSTMLQQLNEIIDSWSNCQQ 1213
XP_027323346 3128 ----------ESAIEI--L-------DSAK-------IMANEITKKQQV--------AEKTELKIAESREGYRPIAKHSS 3173 mallard
6ZYY_C       1517 L--W-------TSLEPVFTGg----D-IARQMPLQAK---QFQGIDKNWMk---IMEKA-VETkkvip----------cc 1565 Tetrahymena t...
EAY20035     1087 StdL-------KTQHSKMTNff---edKVKDFSNFAT---NFKLSATFHM----IL------S----------------- 1126
EGD80062     1881 A--W-------SRVHAPMTAgl---nnNSEEFAHAVT---IYKSTMRQWR----ALCQLgYRS----------------- 1924
XP_021335614  328 K--W-------IFISRTFNE-----N--VHQKFELQE---RFHPADKLFRe---IIEIT-VNDphvcsfvhlstrtefsd 384 
Q57VL9        983 E--WkevlpfgITLETTTDEdfiglT--PRDLKLLRE---KVSSTSDTFKs---LAATLrkaqyt------------lft 1040 Trypanosoma b...
CAM41666      681 R--W-------MRLRACVSSlrsavSeGICSAEEARTitqKLTTASAAFKgmgaILRkpqfsl---------------yt 736 
Q4QIP4       1014 R--W-------VNLRACLSSlrsavAeGICSAEEARLitkSLTMASDAFKelcaILRkpqfsl---------------yt 1069 Leishmania major
XP_001318628  922 L--Y-------LYQNDFMEA--------EDTISHQYSfylTFGDIKSNLTd---LLSKCtcc------------------ 963 
XP_002110236 1214 K--W-------LLLYNVFQR-----KrIKTDLSKQYQ---EFEKINSGYKd---FLRSV-VENpkvlnlvnrrrsqkahk 1272
XP_027323346 3174 V--L------------FF---------SIADLANIDP---MYQYSLSWFVn---LFINS--------------------- 3203 mallard
6ZYY_C       1566 qndM--LKDF-LPDLNRKLEDCQKMLEA---YLEGKRKKFP----RFYFVSNPTLLKILSQg-SEp-tSIQEDFEk-LFD 1632 Tetrahymena t...
EAY20035     1127 ---NqsTADEcN-SIAQDLVKVRDQLQD---VLEMKRKAFP----RFRLLSDSQLIQVISNg-ETp-sKIPTIFSl-MYP 1192
EGD80062     1925 ---EhvLRDLcSPEVGQRLAEYHHQFQEcysLLIATVDAYSvtctRLYMLTPPEVLQLVGQa-RSl-hSIKPLICk-CFS 1998
XP_021335614  385 tlqGqsLRAA-FLNGLTTMEEISNHFLN---VLESARSQFP----RLYCLSDGELIKLLSLqlPAp-sSLLQLIQk-CFT 454 
Q57VL9       1041 ammQenIQDQ-VTLARTILGDVRKILAS---SLDAKREVFP----RFYLMDDESLLSFLSVhnAT---KLKRHLTt-LYS 1108 Trypanosoma b...
CAM41666      737 ammQdtIQDF-LLTIKSEVDDADEVLRG---VTERRRALFP----RFRFLPDSELIEFQSVqsAHsfvHLFQY----LYP 804 
Q4QIP4       1070 ammQdtIQDF-LLTIKSEVDDAAELLRG---MTERRRALFP----RFRFLPDSELMGFQSVqsAHsfaHIFQY----LYP 1137 Leishmania major
XP_001318628  964 -vlSisMTEK-LEVIYDKIRELKEKIYP---YLQNRRKEYY----RLQYLANSELFNYISSt-KNp-eRFSEQVKs-LFP 1031
XP_002110236 1273 dvhGenLLQL-LFNYSDTQDQIIKHLYF---LLEEARNEFP----RFYFISNHQLLDIMSYa-DNp-sALAQFVNh-CFP 1341
XP_027323346 3204 -------------------------------------------------IHDSNKSKILe---KRl-rYLTDHFTynLYC 3230 mallard
6ZYY_C       1633 AITKVTFESakdkkn-----------palkqiTQIQ-QVIGRNEENISLTG------Yyvkceg---niedwLKKLEQNM 1691 Tetrahymena t...
EAY20035     1193 SIASAVFESn----------------------TYCL-GFNSQGGEYFEFIqkvritp---------eciegwFIAFDQQI 1240
EGD80062     1999 DVSDLLLAEg----------------------RKID-GLLAPSGETIRFAqsivatgpthlwlpqlfsemqdFVKFDils 2055
XP_021335614  455 GVKQLDVQVegnvcsthd------ltaltnerMLVH-GIYGEFDEYVPFICplksnlNpv----------awLGLFEQKL 517 
Q57VL9       1109 RVCDVNLEG-----------------------NVVT-SFITTDGSVLR--Td-----Tpielsp--lpveqwMKTFDRTL 1155 Trypanosoma b...
CAM41666      805 RITDVEVV------------------------DRIVtAVVATDGARLPLSSplaltkDtpd---------awIQRFDHAV 851 
Q4QIP4       1138 GITDVEVI------------------------DGVAtAVVAADGARLPLSSplaltkDtpd---------awIQCFDRAV 1184 Leishmania major
XP_001318628 1032 SLDGMIIEN-----------------------NKII-GVIGKNSEQLRLNpieydi----------kdvpllLKTIEMKI 1077
XP_002110236 1342 GILSLKLILpeqtisvmrnttneinaafnahlLQVS-ALEGNLDEVVELTTrikaesQph----------kwFAAVETGM 1410
XP_027323346 3231 NVCRSLF-----------------------------------EKDKLLFSf---------------------LLCCNLLM 3254 mallard
6ZYY_C       1692 QQTLKDI-ASAA 1702 Tetrahymena thermophila SB210
EAY20035     1241 TNTLKTL-GRKI 1251
EGD80062     2056 aherldrlwsev 2067
XP_021335614  518 NQAVKLR-FVKC 528 
Q57VL9       1156 RSSLLNE-IKMS 1166 Trypanosoma brucei
CAM41666      852 RASLVAA-VKEC 862 
Q4QIP4       1185 RASLVAA-VKEC 1195 Leishmania major
XP_001318628 1078 EEKLTKTvIDIA 1089
XP_002110236 1411 KESLAII-LQDC 1421
XP_027323346 3255 AKNEIER-QEFM 3265 mallard
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