5KET


Conserved Protein Domain Family
AKR_AKR1I_CgAKR1

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cd19155: AKR_AKR1I_CgAKR1 
Click on image for an interactive view with Cn3D
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins
Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Statistics
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PSSM-Id: 381381
Aligned: 4 rows
Threshold Bit Score: 542.117
Created: 17-Apr-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:5KET: Coptotermes gestroi aldo-keto reductase in complex with cofactor NADP; contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      ###                      #    #                            #   
5KET_A     11 LSSVTFHNGRKMPVVGLGTWqsppeEVTAAIDVALEVGYRHIDTAFMYqNEAAIGKTLKKWFDSGklKREDVFIVTKLPp 90  Coptotermes gestroi
EFX80600    5 QDHITFWNGEKMPIVGLGTWlsskeEIQTAVNSALEAGYRHIDTAYVYlNEGAIGEVLQEWIQSGkiKREELFIVTKLPm 84  common water flea
NP_649757   4 TKFLTFNNGEKMPVIGIGTWqasdeEIETAIDAALEAGYRHIDTAPVYgNEKAIGRVLKRWLDAGkvKREELFIVTKVPp 83  fruit fly
EEC17634    7 RNCVLMNNGVWIPMLGLATCqgepsVIEKAVETAITAGYRHIDTAYNTrNEAAIGNALRKLIASGrvKREELFIVTKLPr 86  black-legged tick
Feature 1                                  #                                                  
5KET_A     91 igNRAESVEKFLTKSLEALqLDYVDLYLIHLPVgfqykgddnlwprgeageflidtSTDLISLWKAMEAQVDAGRTRSVG 170 Coptotermes gestroi
EFX80600   85 tgNRSENVEKFLRKSLENLrLDYVDLYLIHAPVgligkddndifplnadgsvvldmTTDLVDIWKSMENQVDSGLTKSIG 164 common water flea
NP_649757  84 vsNRPHEVEPTIKKSLEDLqLDYVDLYLVHTPFtininedgsfk-ldkeglmevdvTTNHAAIWVAMEALVEKGLTKSIG 162 fruit fly
EEC17634   87 ggNRREKVKKCLLASLKKLqVNFVDLYLIHFPVhslseeldsg----ptqehkqayQTDILDTWKGMEDAANQGLTRSIG 162 black-legged tick
Feature 1      ##                    #                         #######                        
5KET_A    171 LSNFNSRQIARIVKsaRIRPANLQVELNVYfqQRELVAFCRALdITVCAYAPIGSPglanvikargaevpesakfdpLTD 250 Coptotermes gestroi
EFX80600  165 VSNFNEEQLGRIINnaRIKPANIQVELHTQfqQKSLRDFCQKHgITLCAYAPLGSPgrnafytglg-idspisipdlMQH 243 common water flea
NP_649757 163 VSNFSKDQVARLLKncKIRPANNQIEHHVYlqQRDLVDFCKSEnITVTAYSPLGSKgiakfnaga---givrdlpdlMDI 239 fruit fly
EEC17634  163 LCNFNREQMSRILAvaAIKPANLQVECHAYlnQKDLQQFCSTHsISFTAYAPLGSPaahhasptts--spsgsssklLQD 240 black-legged tick
Feature 1                   #              ######  #  ##                           #
5KET_A    251 PVVLKIAEHHKKTPAQVLLRHCMQRDIVVIPKSTNAGRIKENFQvFDFELSKAEVDELDSLDKRAAGRRF 320 Coptotermes gestroi
EFX80600  244 PAVARIAKKHNKSNAQVLLKYLMELGIAVIPKSVNPGRILANFQvFDFNLSPIDMAKLRELDLGEAGRTF 313 common water flea
NP_649757 240 PEVKEIAASHGKTPAQVLLRWIIDTGVSAIPKSTNPARLKQNLDvFDFELTAEEVAKLSSLDQNIRICDF 309 fruit fly
EEC17634  241 SVLKAIAERHGKSPAQVLIRWLLQRGVVVLPRSTNAAHIHENFQvFDFELTEADMRLVSGLNKNIRLFTF 310 black-legged tick

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