Conserved Protein Domain Family
CYP313-like

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cd11057: CYP313-like 
cytochrome P450 family 313 and similar cytochrome P450s
This subfamily is composed of insect cytochrome P450s from families 313 (CYP313) and 318 (CYP318), and similar proteins. These proteins may be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. Their specific function is yet unknown. They belong to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410680
Aligned: 26 rows
Threshold Bit Score: 509.066
Created: 31-May-2007
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #   #      #          
Q9VHP4     65 KAPFISWMGtsCFLYINdPHSVEQILNSTHCtnkgdfy-rfmssaiGDGLFTSSSPR-WHKHRRLINPAFGRQilsnFLP 142 fruit fly
Q9VGB5     65 GKTVLTWIGltPVLVTCePKILEDIFTSPNCsnrssvvdkaissclGLGLLTLKNNH-WNERRKLLLPSFKNNavlsFVP 143 fruit fly
Q9VGB3     66 GSTCLVWVGptPFVITRdPKIAEEIFLSPEClnrssifskpvnsctGDGLLSLEASK-WVDRRKNLNPAFKQNvllsFLP 144 fruit fly
Q9VG40     65 GPTIFSWLGpiPFMIVSdPQVVQDIFTSPHCvnkgiiy-kavddgaGVGLFSLKDPR-WSIHRKLLNPAFGHKvllsFLP 142 fruit fly
EDW34469   65 GPTNLTWIGsvPVLVTCePNVVQDVLTSPHCldkskiacnplrlicGPATFALNGSH-WVERRKQMNPSFRHNvlmsFLP 143 Drosophila persimilis
EDS43229   71 ELPARAWLGpfLVVAFDhPEHVAVVLNSTQCirrsfm---yrffrfDRGLLMTPDPQhWKLLRKRLNSSFSPLvlknFAP 147 southern house mos...
EDS43232   70 GAPIRFFLGpvPFVIISsPEHAQVILSSSTClakpwi----yrftpLEGIFSLPVDK-WRRHRRAIQPGFNLAvlnsFIP 144 southern house mos...
EAT48682   69 PSPFRAWMGpfLGIIFDkPQHLAVILNSQHCvqksvf---qkffrfDKGLINSDRNI-WRPQRKQLAAPFSYQvvanFAP 144 yellow fever mosquito
Q9VFJ0     66 GSTILTWMGpvPFIVTRdPKVVEDIFSSPDChnksqhivnaitscmGNGLLGKQDPH-WLDRRKHFNPSFKQDlllsFFH 144 fruit fly
Q9VGB4     66 GSTYMAWIGttPIVITRdPKIAEKVLTSPFCinrssqttnalalsmGYGLLTLQGSK-WMARRKHMNPAFKHSvllsFLP 144 fruit fly
Feature 1                                          #                                          
Q9VHP4    143 IFNAEAEVLLQKLELEgvqhgkrleiyqILKKIVLEAACQTTMGkkmnf----qhdgSLCIFKAYNGLTEVCVKRMLSpw 218 fruit fly
Q9VGB5    144 VLNNEANFLVTLLAEFvdggd--inllpELNKWSFKIAAQITMGdevrn---qanyqNGNLLESYKALNNLIPIGVVMpw 218 fruit fly
Q9VGB3    145 IFNSEAKTLVAFLDSLvgqge--kkvrdDIVRWSFRIATQTTVGtdvkk---dasfkNDSVLKSYETFMKIIVMNVLLpf 219 fruit fly
Q9VG40    143 IFNRETALLLDQLEPLqddge--kdlipLLQSFTLGIATQTTMGsdvkd---eesfrSNSLLGRYQCILETMTDMCFSpw 217 fruit fly
EDW34469  144 LFNEETKSLISLLETFvgqge--kkllpEFINWSFRTSIQSTMGsdlkd---npsimNGAIVKKISNLIEVTYHLITFpw 218 Drosophila persimilis
EDS43229  148 AFNECADKLVTSLDKYvdqg-----tfdLLPKVSEFTITATLLNlfkvdlragdnefKEKFAVNAEKLWTLVWRRIYQpw 222 southern house mos...
EDS43232  145 IFKRKIDILVEKLGREvvgggt-fdvygYVAACTLDMVYSTTLGmemni----qqqaRSAYLDVLDELFELVTKRSTNvl 219 southern house mos...
EAT48682  145 SFNEYAEEQLKYLDRFvgaea--fdmlpKLSFYVLSSTLANLFKvqlhs----hdydFMEKKDFHFRMWINIFRRVYKpw 218 yellow fever mosquito
Q9VFJ0    145 IFDAETKVLMNLLDTYvdkge--idvvpEMLRWSFKIAAQTTMGsevkh---dehfkNGSLVESFESLISHSTLNILMpl 219 fruit fly
Q9VGB4    145 IFNAETDLLVSVFDSFvgqge--kdvlsDLIRWSFAIATQTTLGtdvtk---ddnfeNDAILKTYQSMLRLTIINIFVpf 219 fruit fly
Feature 1                                                                                     
Q9VHP4    219 lypdliyrrsglfrlQQKVVGILFGFIEQLLEPIVSVVaansnpdqqrsememrgKSKAIFIEQVREHVErgq-lsWQDV 297 fruit fly
Q9VGB5    219 lrnkylgklfsyekrRLEAATQSNAFIKDIIDKKLSSTd---------------nSSEPALIDRILNLVRige-lsYDDV 282 fruit fly
Q9VGB3    220 thnkifstlggfetqKALAKSNVNKMIGTIVDKKLMTKpes-----------gsqPEITSVINKAIELHRnge-msREEV 287 fruit fly
Q9VG40    218 lnsrfcrqlagkeshYYQAKTEIRQFIRKIIERKLAEDemgal-------psiqsNDKNLFLNLVTDLMRrgv-ftLKNV 289 fruit fly
EDW34469  219 lqnraistlfgfekrKSEAMIHLNASLQSILQEKLKTQades---------keslASRNIVINRAIDFLRsgd-fsYEDV 288 Drosophila persimilis
EDS43229  223 lhldffyqftdrfqeEKQRIRMIRDFTHEISNARDSTRinnnsql----ptqedpPNAEVLIDRLERMAFdtqeidQETF 298 southern house mos...
EDS43232  220 lhpqwayrltsyyrrECRARQIFCAPSTEVLQRNPILArspse--------fsdvSKPQILIDQLYDLSLkdptfdRDAI 291 southern house mos...
EAT48682  219 lisefiyrltpaykmELQQVGKLRALSEEHVAFIQSIVearkvlqqkshpgddhnASSEVLIERLERLTYqtgemtNEEM 298 yellow fever mosquito
Q9VFJ0    220 vqnrmiskicgydklRADNFSRIQKMLDNVVNKKVNPLpkt-----------dsdPESNIVINRAMELYRkgd-itYMDV 287 fruit fly
Q9VGB4    220 vqnkivsklfglewlRRRDASAINKMINNILDKKLNSNpen-----------yceSELKTVIHRAIELFRnde-msLMEL 287 fruit fly
Feature 1          ##  ##  ##  #                                                    #        #
Q9VHP4    298 RDEANVTIAATFETTSTALYFTILCLAMHPCYQEKLHKELVTELPpsgdin--leqlqRLEYTEMVINEAMRLFAPVPMV 375 fruit fly
Q9VGB5    283 MGEFSNIIFAASDTLSITVNNVLILMAMFPKYQDNVFEELAEVFPsggefeashadleKLVKLDRVLHETMRLIPAVPLL 362 fruit fly
Q9VGB3    288 QSECCSFVVAAFETTGDTVYHALILLAMFPEHQDTVYQELKELFPvagdfevtyddlqRMVFLERVVNETLRLIPSVPFT 367 fruit fly
Q9VG40    290 EDESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPntgdfdvsyadtqQMVYLDLILNESMRVIPPVPVV 369 fruit fly
EDW34469  289 KSECILTIVAGFETSAITVFNTLILLAMFPEYQDTAFEELKDVFPnvgdfevsyddlqKLVYMDRVLNESLRLLPPLPLI 368 Drosophila persimilis
EDS43229  299 LSNIDTFMFASNDTTSNVMSTTLLMLAMHPEIQERVFAEVSQVTAtssfip--qealsKLVYLEMVIKETMRLVPVGSIL 376 southern house mos...
EDS43232  292 EKELNTMIFGGNETTAITMSNALLLIAMHPEVQNKLIVEITQVLGesfani-tieqlqQLTYMEAVLKEAMRLYPITTIL 370 southern house mos...
EAT48682  299 MDNIDTFLFAAVDTTTSTMASTLLMMAIHPEVQERVYQEVSQVVPndyia---iedlpNLVYLERVMKETMRLIPIAGML 375 yellow fever mosquito
Q9VFJ0    288 KSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPdaghfgitypdmqKLDYLERVIKETLRLIPAIPIT 367 fruit fly
Q9VGB4    288 GAECSSMVLAAFETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPlakgievthtdlqQLVYLDRVLNETLRLMPSVPFS 367 fruit fly
Feature 1      #                          #                                    ###   #####  ##
Q9VHP4    376 LRSADQDIQLKrgdgEFLIPRGTQIGIDIYNMQRDERVWgPLSRTYNPDAHFgldspqrHAFAFVPFTKGLRMCIGYRYA 455 fruit fly
Q9VGB5    363 IRQTSHSIQLSn---GFYIPEGVTLMIDIFHTHRNKDIWgPQANAFNPDNFLpenkrarPPYSYLPFSKGKKTCLGWKLS 439 fruit fly
Q9VGB3    368 PRETIRDFRLSs---GVVIPKGVGIGIDIFATHRNRDHWgTDPSSFNPDHFLpdnvrdrHPYAYIPFSKGRRNCIGWKYG 444 fruit fly
Q9VG40    370 SRQTSQDLKLSn---GIVVPKGVQIAIDIYHMHRSKKIWgPDAETFNPDHFLphniqdkHPYAYIPFTKGIRNCIGWRYA 446 fruit fly
EDW34469  369 PREVTEDLKLSn---GILIPKGVTVAIDIFHTHRNKDFWgLEADTFNPDNFLpehiqerHPYVFIPFNRGKRNCAGRKYA 445 Drosophila persimilis
EDS43229  377 GRICEKELTVD----QWTIPAGTEVVIPIFKMHRNKAVWgERSEEFDPDNFLpercaqrHPYAYIPFSGGIRNCIGMKYA 452 southern house mos...
EDS43232  371 GRKTGADLQLG----EYRIPAGVNLAIDVFSIHRSAEHWgLNADLFVPERFLtg---khHPYAFLGFSAGPRNCIGIRYA 443 southern house mos...
EAT48682  376 NRVCEKELQVG----EWTIPVGATIGIPVLKVHRDRAIWgERSDEFDPDNFLpekvaqrHPYAYIPFSAGIRNCVGMRYA 451 yellow fever mosquito
Q9VFJ0    368 ARETKNDVRLSn---GVLIPKGVVIGIDMFHTHRNPEVWgPDADNFNPDNFLaenmeqkHPYAYIPFARGKRNCIGSKYA 444 fruit fly
Q9VGB4    368 SRETLEDLRLSn---GVVIPKGMTISIDIFNTQRNTDYWgSEAAQFNPENFLpekihdrHPYAFIPFSKGKRNCIGWRYG 444 fruit fly
Feature 1                                                
Q9VHP4    456 QMLMKLLLARIFRSYRistearLEELLVKGNIslKLKDYPLCR 498 fruit fly
Q9VGB5    440 LISAKLALAKILRNYMlsttflYKDLRFIDNTtmKLAEQPLLA 482 fruit fly
Q9VGB3    445 LMSSKLALSKILRNCKvstsfrYEDLEFVDNIgmELAQSPGLE 487 fruit fly
Q9VG40    447 LISAKVTLAKLLRNYRfktsfpFENLYFVEDItmKLKSVPLLE 489 fruit fly
EDW34469  446 EISIKIALAKILRNFRlstsfrFEDLSFVDNIvlEFKEQPLLE 488 Drosophila persimilis
EDS43229  453 YMSLKIVLAKLIARYRfrtelkLEQLKFEPSLilLIVNKHMVR 495 southern house mosquito
EDS43232  444 WISMKMTLAHVLRRFEletplrLQDIRIKASMtlKVIGGHIIS 486 southern house mosquito
EAT48682  452 NVSMKVLLAKLVKRFRfktdlrMKDLKFEAAFlmMLANKHMMR 494 yellow fever mosquito
Q9VFJ0    445 MMSSKFALCRILRNYKiststlYKDLVYVDNMtmKLAEYPRLK 487 fruit fly
Q9VGB4    445 LMSSKLALVKILRNYKlktsfpYENLEFVDHMviKLAQSPQLA 487 fruit fly

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