1MKX,1AUT,1BRU,1EKB,1A0L,1PPG,1C1M,1FUJ,1EX3,1TGB,1NPM,1PYT,1A5I,1BIT,1PFX,1KIG,1BUI,1TON,1PYT,1EJN,1FDP,1KLT,1AZZ,1TRY,1AU8,2HLC,1AE5,1SGT


Conserved Protein Domain Family
Tryp_SPc

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cd00190: Tryp_SPc 
Click on image for an interactive view with Cn3D
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.
Statistics
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PSSM-Id: 238113
Aligned: 177 rows
Threshold Bit Score: 124.696
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:catalytic triad for serine proteases
  • Citation:PMID 8140095

cd00190 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00190 is a member of the superfamily cl21584
cd00190 Sequence Cluster
476147246306610790121572759273886727388691AZZ A283333228332842HLC A43299013443223536991595778455812463064211657660952623531591176131TRY 107211410786911364301SGT 116038824630984618581906316136424164428113360535476993123228171778517177821717788171778917177867311011717791171779226716116986682671601698666464953464943211806425072482765010108569912565691894737189473514809111PPG E1FUJ A1AE5 1FDP A228614317080371KLT 17089574002361AU8 A1215833123249170804612158533344661708047170803512158123674931TGB 1BIT 1364314649651NPM A273792117108781TON 13463851251731251741251702851459119586391448039144771341291148372114118211411611382711698981MKX K1AUT C1PFX C1KIG H119760249985911976573878591152041152051235085853981352202205530320553052133785246309624631001777334103071858490839156427500230107895454251712968827388632443296108513286073510851315490031709248225339311910313458727388652133693181755473209132326314285238175121761A5I A1371111EJN A547643135240747585021040111161331BRU P1PYT D135477913361721PYT C1C1M A1EX3 A170619072922475121781BUI A123115113067613997511231161A0L A1364232734092259950428332771EKB B12305711976233343771132086225760751119974356267512176
Sub-family Hierarchy
cd00190Tryp_SPc
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                         #                           
1MKX_K     50 IVEGQDaev----glSPWQVMLFrks-----pqeLLCGASLISd-RWVLTAAHCLlyppwdknftvddLLVRIGKHSRtr 119 Bos taurus
1BUI_A     21 VVGGCVahp----hsWPWQVSLRtrf------gmHFCGGTLISp-EWVLTAAHCLeksp-----rpssYKVILGAHQEvn 84  human
1644281    27 IVGGEEaia----heFPYQISLQwnynndeqdpfHFCGGSLIAe-KFVLTAGHCVpsais----pdgfPEAVAGEHDFsq 97  African malaria mo...
1336053    26 IVGGDEaea----heFPYQISLQwnfndgqtetmHFCGASVLNe-NFVLTAAHCKtays-----ntgfIEVVAAEHDVav 95  yellow fever mosquito
117613      1 IVGGTDapr----gkYPYQVSLRap--------kHFCGGSISK--RYVLTAAHCLvgks------khqVTVHAGSVLLnk 60  European hornet
2765010    32 IIGGTEani----snFPWQVSVEsa-------gdHTCGGSLISp-DWVLTFSLCLdgfs-----gvfeHLLQFVSLRAgt 94  Schistocerca gregaria
2326314   335 INEDFRaey----geFPWMVALFqlp-----eqrYCCNGALIDp-KAILTTAHCVtncgg----raanIMVRFGEWNMss 400 African malaria mo...
2833332    33 VVGGEVakn----gsAPYQVSLQvpg------wgHNCGGSLLNd-RWVLTAAHCLvgha------pgdLMVLVGTNSLke 95  African malaria mo...
2833284    50 IVGGSVase----gqFPHQVALLrg-------naLTCGGSLIEs-RWVLTAAHCVyn---------gaLVVPASSIVVva 108 African malaria mo...
476147     51 IVGGREvddydedtgVHFIAKLFlpd-----gngFYCSGSVISksGHVLTRAGCEpr---------vnDVVRLGGSRLyn 116 Porphyra purpurea
Feature 1                                   #                                                 
1MKX_K    120 ye--rkveKISMLDKIYIHpRYnwkenldRDIALLKLkrPIELsdyiHPVCLPDkqtaaklLHagFKGRVTGWGNRretw 197 Bos taurus
1BUI_A     85 le---phvQEIEVSRLFLEpTR-------KDIALLKLssPAVItdkvIPACLPSpn---yvVAdrTECFITGWGETqgt- 150 human
1644281    98 yd---agvQRRRIAEMYVHeDYegs-vgpNDIAIFRVdkPFHLnrniQLVSLPEp-----nAIptGETTISGWGSTsfsf 168 African malaria mo...
1336053    96 ae---gseQRRLVAEFIVHeDYqgg-vspDDIAVIRVdkPFELndkvKAVKLPKq-----lEQfdGDVTLSGWGSVsttv 166 yellow fever mosquito
117613     61 ------eeAVYNAEELIVNkNYnsi-rliNDIGLIRVskDISYtqlvQPVKLPVsn----tIKagDPVVLTGWGRIyvn- 128 European hornet
2765010    95 stk-gsggVVLLAAEMYEHpLYipl-tvdYDVALIKVngSFALgpnvQAVSLPEqg---ydPPvgLPVTITGWGYNvtd- 168 Schistocerca gregaria
2326314   401 themaiprEDIGVKSVHQHpRYsps-allNNIAVLELahPVQYqatiQPVCLPSan---qpLRamENMIATGWGRVmeen 476 African malaria mo...
2833332    96 ------ggELLKVDKLLYHsRYnlp-rfhNDIGLVRLeqPVQFselvQSVEYSEk-----aVPanATVRLTGWGRTsan- 162 African malaria mo...
2833284   109 gsvslsngVRRAVARVITHeRYgn---fkNDVALLQLqlSLPSsayiRPIALRTs-----sVPagSEVVISGWGVCtkv- 179 African malaria mo...
476147    117 -------gVVARVAKVSIHpKYdpa-gevADVAVLKLkgVSESrl-lRAGVVPVfln--rvWDnpHGMYFTGYGATdkaa 185 Porphyra purpurea
Feature 1                                                                         #           
1MKX_K    198 ttsvaevqPSVLQVVNLPLVERpVCkastr------------iritdNMFCAGYkpgegkrGDACEGDSGGPFVMKspy- 264 Bos taurus
1BUI_A    151 ------fgAGLLKEAQLPVIENkVCnryefl----------ngrvqsTELCAGHla---ggTDSCQGDSGGPLVCFek-- 209 human
1644281   169 ----epsyPNILMKTTLPIMDLeVCrkiyft-----------etvadSNICAGTme---gtSSVCSGDSGGPLVQIdd-- 228 African malaria mo...
1336053   167 ----fpdyPDKLRKVVLPLVDYeQCdtlwgn----------dsalakSNVCAGPid---gsKSACSADSGGPLVKQsg-- 227 yellow fever mosquito
117613    129 -----gpiPNNLQQITLSIVNQqTCkfkhw-------------gltdSQICTFTkl----gEGACDGDSGGPLVAN---- 182 European hornet
2765010   169 -----gslSSVLQKVDVNIVDRaVCqatyvi-----------rnvtaRMVCAGEl-----lRGSCDGDFGXPLVSG---- 223 Schistocerca gregaria
2326314   477 -----appTQILKRLDLQRMEPsICrealrrvrr-----pypfildsSFVCSTTnhg--dqERPCDGDAGAPVVVElpgt 544 African malaria mo...
2833332   163 -----gpsPTLLQSLNVVTLSNeDCnkkggd----------pgytdvGHLCTLTkt----gEGACNGDSGGPLVYE---- 219 African malaria mo...
2833284   180 -----apyQTCFDTTVLPVVADqQCrdpt--------------gistGLICFTSpv----nNGACNGDSGGPAILN---- 232 African malaria mo...
476147    186 ----qsagSLTLKRAYLPVAPWwNCrritdtvvvpglsrpglpispaAQVCLRGgr---gaGALCERDPGGPMYRVsthr 258 Porphyra purpurea
Feature 1                                                   
1MKX_K    265 -nnrWYQMGIVSWGEg------CdrdgKYGFYTh-VFRLKKWIQKV 302 Bos taurus
1BUI_A    210 --dkYILQGVTSWGLg------CarpnKPGVYVr-VSRFVTWIEGV 246 human
1644281   229 ---eIVQVGIVSWGGi-----pCggykNPGVFVr-VSYFIDWINDK 265 African malaria mosquito
1336053   228 --eeVIQVGVVSWGAv-----pCgsprRPTVFAg-VSHYVDWIEQQ 265 yellow fever mosquito
117613    183 ----GVQIGIVSYGHp------Cav-gSPNVFTr-VYSFLDWIQKN 216 European hornet
2765010   224 ----STQVGVLSWTLf-----pCe--lGLDVYAn-VVSFRSWISEV 257 Schistocerca gregaria
2326314   545 -tnrYYLHGLVSWGYg------ChqkqIPYTVLtkVVHFREWIDRI 583 African malaria mosquito
2833332   220 ----GKLVGVVNFGVp------Cal-gYPDGFAr-VSYYHDWVRTT 253 African malaria mosquito
2833284   233 ----NQLVGRPNFIIn-----yCgs-aSPDGYAk-VSDFVTWIQTT 267 African malaria mosquito
476147    259 gvkiYTLYAVSSYWIglgadnrCpr-aMPNVGSk-VAFYYSWIQNQ 302 Porphyra purpurea

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