Conserved Protein Domain Family
pyrF_sub2

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TIGR02127: pyrF_sub2 
orotidine 5'-phosphate decarboxylase, subfamily 2
This model represents orotidine 5'-monophosphate decarboxylase, the PyrF protein of pyrimidine nucleotide biosynthesis. See TIGR01740 for a related but distinct subfamily of the same enzyme. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]
Statistics
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PSSM-Id: 273987
Aligned: 9 rows
Threshold Bit Score: 296.626
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAD77710       4 FATQLNAAILRTGSVTCVGLDPRLEQLPKPLRDSVSekrkdsv---aaaytqfCCEIIDAVAGLVPCVKPQAAFFEQLGP 80  Rhodopirellula ...
Q9RSC5         5 FAQAVTERTLSRRTRLCVGLDPRLGEYRDVAQLRQN-----------------TLDVLEASAPYAACVKPQLAFFEALGL 67  Deinococcus rad...
P77898         4 FGLRLAEAK-ARRGPLCLGIDPHPELLRGWDLATTAdgl-----------aafCDICVRAFAD-FAVVKPQVAFFESYGA 70  Mycobacterium t...
CAD67076       4 FGDRLQNAF-TDFGHLCVGIDPHEWILEQWGLPNSPaga-----------qefALRILDLSSEHVGLYKVQVAFYERFGS 71  Tropheryma whip...
P24220         7 FAHRFSQLA-EQRSPFCLGIDPSRDLLTRWGLPDNArgl-----------rdfCERVADAAGSSVAVVKPQSAFFERHGP 74  Myxococcus xant...
P58883         2 FVDRLIESVKAKKTPVVVGLDPRIEMIPDFIKEEAFrrkgngvegiaeamylfNKGIIDAVYDLIPAVKIQVAFYEAYGI 81  Caldanaerobacte...
BAA31359       5 FFDMLNER--AKSTLLCIGLDSRAKTAAEAKKEC--------------------MRLIDATAEYAAAYKPNAAFFEFFGG 62  Trypanosoma cruzi
Q9P9M3         3 FVEELGARIEAADSVVSVGLDPDMERLPEDVQDAELprw------------afNRRIIDATHEHAAVFKPNAAFYE--DS 68  Halobacterium s...
WP_000509034   7 FQSKFLTRSQSLKSLLCVGLDPDFDKLPEIVKRSPEplv------------qfCKEIIDATASYAVAYKPNIAFFEVFGS 74  Leptospira inte...
CAD77710      81 AGMVSLGEVISHANQAG--LIVITDGKRNDIGSTATAYADAYLGSAEpdrspwgsDALTVSPYLGRDSLEPFVEVCDRRA 158 Rhodopirellula ...
Q9RSC5        68 PGFTLLEEVCAAARTLG--LPVLLDGKRGDIGTTAAAYAQGWLGGTHa------gDALTVNPFLGFQTLTPFVQAARENG 139 Deinococcus rad...
P77898        71 AGFAVLERTIAELRAAD--VLVLADAKRGDIGATMSAYATAWVGdsp-----laaDAVTASPYLGFGSLRPLLEVAAAHG 143 Mycobacterium t...
CAD67076      72 KGIFALEEVISAIRSTG--ALVIADGKRGDISSTMSGYAKAWLCRdsr----lfsDALTVSPYVGLGSFKGSIDIARQNG 145 Tropheryma whip...
P24220        75 EGLQVLQELMRRFKSVG--TLTLLDVKRGDIGSTMEAYAETVFGEgsa----yeaDAATFTAYLGLGALLKTLERARASG 148 Myxococcus xant...
P58883        82 EGFKAFFRTAEYAKSLG--LIVIADVKRGDIQDVAKMYSKAYLQNPLf-------DAITVNPYMGEDSMVPYLEDVEKFG 152 Caldanaerobacte...
BAA31359      63 EGWKALQQVIAHVPAN---IPVVLDAKRGDIADTAEAYAKSAFEHLKa-------HAITTSPYMGGDSLSPFLQYTS--- 129 Trypanosoma cruzi
Q9P9M3        69 DGWRALRETVAYAHGKG--VPVLLDAKRADIGNTARQYAEILA-Hv---------DAITVNPYLGEDALQPFLTQDE--- 133 Halobacterium s...
WP_000509034  75 SGIRQFEKVIGHLKSNYpqIPIVADVKRGDLDNTARQYAKYYFGDLQv-------DSLTLSPYMGLDSIRPFLEYQD--- 144 Leptospira inte...
CAD77710     159 AGIFVLVKTSNPGGGYLQDLSVDGk-----------------TIYQSVAELVTELNKSRLDadgygPVGAVVGATYPEQL 221 Rhodopirellula ...
Q9RSC5       140 GAIFVLVKTSNPDQQDLQGQGVSE------------------RIAVEIARLGDEEGLGDGDy---aSVGAVVGATHPGDL 198 Deinococcus rad...
P77898       144 RGVFVLAATSNPEGAAVQN-AAADg----------------rSVAQLVVDQVGAANEAAGPgp--gSIGVVVGATAP-QA 203 Mycobacterium t...
CAD67076     146 AGLFFLAATSEMHAFPIQSAILQDrqgtfgessgsilscsdiTVASYIFESIGTLVGNPSDc---sSFGVVLSATS--DL 220 Tropheryma whip...
P24220       149 AAAFLVVRSSNPEGTSLQMSRGEDg----------------rTVAEALADGLRAFNEKPGQda-apVAGAVMGATLP-DS 210 Myxococcus xant...
P58883       153 KGIFVLVKTSNRSSKDVQDIETKKg----------------gYVYQEVAKMISRLSKVIVGkygysSIGAVVGATYPFEA 216 Caldanaerobacte...
BAA31359     130 KGVFVLCKTSNKGSNEIQCLRVNGr-----------------RLYESVAEHAETVWNYNK------NVGLVVGATDPIAL 186 Trypanosoma cruzi
Q9P9M3       134 AGVFVLCRTSNEGGMDFQHLELAAyd---------------rRLYEHVAERAAEWNAQYG------DVGLVVGATAPDEL 192 Halobacterium s...
WP_000509034 145 YLIFWLCLTSNPDSAQFQKKRFSEtg---------------rTLYEEVVYVANLVAIS--------NLGFVVGATSPSEL 201 Leptospira inte...
CAD77710     222 VELRKA------MPHSILLVPGFGAQG-GSADDVRAAMDANGAGAVVNSSRHIVFAHKR-EEFSVAAD 281 Rhodopirellula baltica SH 1
Q9RSC5       199 ATFRAL------MPKALLLLPGLGAQG-AQARDLAGAFHAGGTGALASASRAVQYARGL-DVGAAREA 258 Deinococcus radiodurans R1
P77898       204 PDLS--------AFTGPVLVPGVGVQG-GRPEALGGLGGAASSQLLPAVAREVLRAGPG-VPELRAAG 261 Mycobacterium tuberculosis
CAD67076     221 LSLGIGcnlsefSRVMPILAPGFGYQG-VELKDSRKRFGSLISNLIISESRSLLASGPRrFSALVNTR 287 Tropheryma whipplei TW08/27
P24220       211 DRGVIEr-----LGGALLLTPGIGAQG-AGFDDLKRLFAGREAQVIPTATRSVLEAGPD-TAALRQAL 271 Myxococcus xanthus DK 1622
P58883       217 KILREE------MPRCYFLVPGYGAQG-ATAEDVVNCFDEEGYGAIINSSRGVIYAYR--SDFWKEAY 275 Caldanaerobacter subterrane...
BAA31359     187 SRVRVR------APTLWFLVPGIGAQGgDLKAALNAGLRADGSGLLINVSRAVARAKDP-RAAAKKLC 247 Trypanosoma cruzi
Q9P9M3       193 QAIRER------VPELPFLVPGVGAQGgDAEAAVEYGLNDDGVG-LVNSTRGVIFAGEH-GSAWAAAA 252 Halobacterium sp. NRC-1
WP_000509034 202 ETLRTQ------NPNRIFLIPGFGAQG----AKLENLLPVCGRNSLINSSRGIHFASNG-SDFAVRAG 258 Leptospira interrogans
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