6TTW,7O29


Conserved Protein Domain Family
MT-A70

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pfam05063: MT-A70 
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MT-A70
MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m6A methyl-transferase (MTase), an enzyme that sequence-specifically methylates adenines in pre-mRNAs.
Statistics
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PSSM-Id: 368270
Aligned: 9 rows
Threshold Bit Score: 206.901
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6TTW_B 186 FDVILLEPPLEEYY--RETgi---tANEKCWTWDDIMKLEIDEIAAP-RSFIFLWCGSGEGLDL--GRVCLRKWGYRRCE 257 human
Q09800 234 PKCIIIDPPWPNKSvaRSS------VYKVNRNLGYLKALPIQESLSK-TGVVAVWCTNKEKYVNfvKKVLFKKWNLTLVS 306 Schizosaccharomyces p...
Q09956 185 FDLIIADPPWFSKSvkRK--------RTYQMDEEVLDCLDIPVILTH-DALIAFWITNRIGIEEe-MIERFDKWGMEVVA 254 Caenorhabditis elegans
Q9VER8 155 YDLIVLDPPWRNKYirRLKrak-peLGYSMLSNEQLSHIPLSKLTHP-RSLVAIWCTNSTLHQLalEQQLLPSWNLRLLH 232 fruit fly
Q9KIW1  10 YQCIIIDPPWFYRLrsKDKthr-nrIPYQPMRTPEILALPIPDLCDAgGCVLWLWFTNNHMIEA---AQCLQRWGFDLKT 85  Nostoc sp. PCC 7120
Q9VLP7 158 FDVILIEPPLEEYAraAPSvatvggAPRVFWNWDDILNLDVGEIAAH-RSFVFLWCGSSEGLDM--GRNCLKKWGFRRCE 234 fruit fly
P41833 342 FSVVIADPAWNIHMn----------LPYGTCNDIELLGLPLHELQDEg--IIFLWVTGRAIELG---KESLNNWGYNVIN 406 Saccharomyces cerevis...
7O29_A  55 FAVVMADPPWDIHMe----------LPYGTLTDDEMRRLNIPVLQDDg--FLFLWVTGRAMELG---RECLNLWGYERVD 119 human
O82486 476 FGVVMADPPWDIHMe----------LPYGTMADDEMRTLNVPSLQTDg--LIFLWVTGRAMELG---RECLELWGYKRVE 540 thale cress
6TTW_B 258 DICWIKTN-KNNPGKtkTLDPKavFQRTKEHCLMGIKGTVKRSTDGDFIha-----nvDIDLIITeePEIGNIEKPVEIF 331 human
Q09800 307 TWTWLKITaFGEPLF--DVYSN--MRKPWEQLLIGVTSEYTSVYSDKIP---------PTFTIIG--IPDYHSRKPSLKP 371 Schizosaccharomyces p...
Q09956 255 TWKLLKITtQGDPVYdfD---NqkHKVPFESLMLAKKKDSMRKFe------------lPENFVFAsvPMSVHSHKPP-LL 318 Caenorhabditis elegans
Q9VER8 233 KLRWYKLStDHELIAp--PQSDltQKQPYEMLYVACRSDASENYGKd----------iQQTELIFsvPSIVHSHKPPLLS 300 fruit fly
Q9KIW1  86 ILTWGKVTkDGTKTH---LGVGhwLRNSTEHCALAVRGNVKAFAGQTSTtggtptltnQSTILHS--PRREHSRKPPEFF 160 Nostoc sp. PCC 7120
Q9VLP7 235 DICWIRTN-INKPGHskQLEPKavFQRTKEHCLMGIKGTVRRSTDGDFIha-----nvDIDLIISeeEEFGSFEKPIEIF 308 fruit fly
P41833 407 EVSWIKTNqLGRTIV--TGRTGhwLNHSKEHLLVGLKGNPK------WInk-----hiDVDLIVS--MTRETSRKPDELY 471 Saccharomyces cerevis...
7O29_A 120 EIIWVKTNqLQRIIR--TGRTGhwLNHGKEHCLVGVKGNPQ------GFnq-----glDCDVIVA--EVRSTSHKPDEIY 184 human
O82486 541 EIIWVKTNqLQRIIR--TGRTGhwLNHSKEHCLVGIKGNP-------EVnr-----niDTDVIVA--EVRETSRKPDEMY 604 thale cress
6TTW_B 332 HIIEHFC----LGRR-RLHLFGRDstIRPGWLTVGPT 363 human
Q09800 372 FISRWFNcsanESLP-VLEIFGRS--LTPNWITWGRE 405 Schizosaccharomyces pombe 972h-
Q09956 319 DLLRHFGi---EFTE-PLELFARS--LLPSTHSVGYE 349 Caenorhabditis elegans
Q9VER8 301 WLREHLLldkdQLEPnCLELFARY--LHPHFTSIGLE 335 fruit fly
Q9KIW1 161 ELVEKLC----PDMT-KLEIFARE--SRDGWDCWGDQ 190 Nostoc sp. PCC 7120
Q9VLP7 309 HIIEHFC----LGRR-RLHLFGRDssIRPGWLTVGPE 340 fruit fly
P41833 472 GIAERLAg---THAR-KLEIFGRDhnTRPGWFTIGNQ 504 Saccharomyces cerevisiae S288C
7O29_A 185 GMIERLS----PGTR-KIELFGRPhnVQPNWITLGNQ 216 human
O82486 605 AMLERIM----PRAR-KLELFARMhnAHAGWLSLGNQ 636 thale cress
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