2ASI,2APR,5RBT,1J71,3Q70,3TNE,1AVF,5MLG,4GJ5,4AA8


Conserved Protein Domain Family
Asp

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pfam00026: Asp 
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Eukaryotic aspartyl protease
Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.
Statistics
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PSSM-Id: 394983
Aligned: 24 rows
Threshold Bit Score: 267.988
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2ASI_A  19 EYAIPVSIGTPGQDFLLLFDTGSSDTWVPHKG----------------------CTk-SEG-----CVGSRF-FDPSASS 69  Rhizomucor miehei
2APR_A  16 EYYGQVTIGTPGKKFNLDFDTGSSDLWIASTL----------------------CTn---------CGSGQTkYDPNQSS 64  Rhizopus microsporus ...
5RBT_A 105 AYITPVQIGTPAQTLNLDFDTGSSDLWVFSSE----------------------TT--ASE-----VDGQTI-YTPSKST 154 chestnut blight fungus
P17946  84 EYLTPVTVGKS--TLHLDFDTGSADLWVFSDE----------------------LP--SSE-----QTGHDL-YTPSSSA 131 Aspergillus awamori
P32834  75 GYFANLTLGSNERVYSLTLDTGSPYTWVTAKNitalsaseiwsdtdgvdagrstSDirTNA-----CTNYTC-FDYSSTT 148 Schizosaccharomyces p...
P22929  74 FYLTTIEIGTPGQKLQVDVDTGSSDLWVPGQG----------------------T-----------SSLYGT-YDHTKST 119 Saccharomycopsis fibu...
P12630  44 YYATTLDIGTPSQSLTVLFDTGSADFWVMDSSnpfclpnsntssysnatyngeeVKp-SID-----CRSMST-YNEHRSS 116 Saccharomyces cerevis...
1J71_A  13 SYAADIVVGSNQQKQTVVIDTGSSDLWVVDTDa--------------------eCQvtYSGqtnnfCKQEGT-FDPSSSS 71  Candida tropicalis
3Q70_A  13 TYAADITVGSNNQKLNVIVDTGSSDLWVPDVNv--------------------dCQvtYSDqtadfCKQKGT-YDPSGSS 71  Candida albicans
3TNE_B  13 SYASKVSVGSNKQQQTVIIDTGSSDFWVVDSNa--------------------qCGk-GVD-----CKSSGT-FTPSSSS 65  Candida parapsilosis
2ASI_A  70 TFK-ATNYNL-NIT-YGTG-GANGLYFEDSIAIGDITVTKQILAYVDNVRGPTAEQSPnadifLDGLFGAA----YPDNT 141 Rhizomucor miehei
2APR_A  65 TYQ-ADGRTW-SIS-YGDGsSASGILAKDNVNLGGLLIKGQTIELAKREAAS-FASGP-----NDGLLGLG----FDTIT 131 Rhizopus microsporus ...
5RBT_A 155 TAKlLSGATW-SIS-YGDGsSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDST-----IDGLLGLA----FSTLN 223 chestnut blight fungus
P17946 132 TK--LSGYTW-DIS-YGDGsSASGDVYRDTVTVGGVTTNKQAVEAASKISSEFVQNTA-----NDGLLGLA----FSSIN 198 Aspergillus awamori
P32834 149 ARR-TNSSTIgFLAsYGDNtTVLGYNMVDNAYFAGLTLPGFEFGLATREYDSSQISV------TPGIIGLSvamtITGIS 221 Schizosaccharomyces p...
P22929 120 SYK-KDRSGF-SIS-YGDGsSARGDWAQETVSIGGASITGLEFGDATSQDV------------GQGLLGIG----LKGNE 180 Saccharomycopsis fibu...
P12630 117 TYQyLENGRF-YIT-YADGtFADGSWGTETVSINGIDIPNIQFGVAKYATTP-----------VSGVLGIG----FPRRE 179 Saccharomyces cerevis...
1J71_A  72 SAQ-NLNQDF-SIE-YGDLtSSQGSFYKDTVGFGGISIKNQQFADVTTTSV------------DQGIMGIG----FTADE 132 Candida tropicalis
3Q70_A  72 ASQ-DLNTPF-KIG-YGDGsSSQGTLYKDTVGFGGVSIKNQVLADVDSTSI------------DQGILGVG----YKTNE 132 Candida albicans
3TNE_B  66 SYK-NLGAAF-TIR-YGDGsTSQGTWGKDTVTINGVSITGQQIADVTQTSV------------DQGILGIG----YTSNE 126 Candida parapsilosis
2ASI_A 142 AME------AEYGstYNTvhvnLYKQGLISSPLFSVYMN--TNSGTGEVVFGGVNNTLLGGDIAYTDVMSr------yGG 207 Rhizomucor miehei
2APR_A 132 TVRg-----VKTP--MDN----LISQGLISRPIFGVYLGkaKNGGGGEYIFGGYDSTKFKGSLTTVPIDNs-------RG 193 Rhizopus microsporus ...
5RBT_A 224 TVSpt---qQKTF--FDN------AKASLDSPVFTADL---GYHAPGTYNFGFIDTTAYTGSITYTAVSTk-------QG 282 chestnut blight fungus
P17946 199 TVQpk---aQTTF--FDT----VKSQ--LDSPLFAVQL---KHDAPGVYDFGYIDDSKYTGSITYTDADSs-------QG 257 Aspergillus awamori
P32834 222 SDDkv--vaFTPPtiVDQ----LVSANVIDTPAFGIYLN----EDVGELIFGGYDKAKINGSVHWVNISSsd-----dST 286 Schizosaccharomyces p...
P22929 181 ASAqs---sNSFT--YDNlplkLKDQGLIDKAAYSLYLNs-EDATSGSILFGGSDSSKYSGSLATLDLVNiddegdstSG 254 Saccharomycopsis fibu...
P12630 180 SVKgy---eGAPNeyYPNfpqiLKSEKIIDVVAYSLFLNs-PDSGTGSIVFGAIDESKFSGDLFTFPMVNeyptivdaPA 255 Saccharomyces cerevis...
1J71_A 133 A--------GYNL--YDNvpvtLKKQGIINKNAYSLYLNs-EDASTGKIIFGGVDNAKYTGTLTALPVTS--------SV 193 Candida tropicalis
3Q70_A 133 AGG------S-----YDNvpvtLKKQGVIAKNAYSLYLNs-PDAATGQIIFGGVDNAKYSGSLIALPVTS--------DR 192 Candida albicans
3TNE_B 127 AVYdtsgrqTTPN--YDNvpvtLKKQGKIRTNAYSLYLNs-PSAETGTIIFGGVDNAKYSGKLVAEQVTS--------SQ 195 Candida parapsilosis
2ASI_A 208 YyfWDAPVTGITVDGSAA-----VRFSRPQAFt------IDTGTNFFIMPSSAASKIVKAALPDATETqqg---wvVPCA 273 Rhizomucor miehei
2APR_A 194 W--WGITVDRATVGTSTV-------ASSFDGI-------LDTGTTLLILPNNIAASVARAYGASDNGDgt----ytISCD 253 Rhizopus microsporus ...
5RBT_A 283 F--WEWTSTGYAVGSGTF------KSTSIDGI-------ADTGTTLLYLPATVVSAYWAQVSGAKSSSsvg--gyvFPCS 345 chestnut blight fungus
P17946 258 Y--WGFSTDGYSIGDGSS------SSSGFSAI-------ADTGTTLILLDDEIVSAYYEQVSGASGETeag--gyvFSCS 320 Aspergillus awamori
P32834 287 F--YSVNLESITVTNSTSsnnvqSSKRSSKDIevnttvtLDTGTVYIYLPEDTVESIADQYQGIVSEYgy----vvIYCD 360 Schizosaccharomyces p...
P22929 255 AvaFFVELEGIEAGSSSI------TKTTYPAL-------LDSGTTLIYAPSSIASSIGREYGTYSYSYgg----yvTSCD 317 Saccharomycopsis fibu...
P12630 256 T--LAMTIQGLGAQNKSScehetFTTTKYPVL-------LDSGTSLLNAPKVIADKMASFVNASYSEEegi---yiLDCP 323 Saccharomyces cerevis...
1J71_A 194 E--LRVHLGSINFDGTSV-------STNADVV-------LDSGTTITYFSQSTADKFARIVGA--TWDsrneiyrlPSCD 255 Candida tropicalis
3Q70_A 193 E--LRISLGSVEVSGKTI------NTDNVDVL-------LDSGTTITYLQQDLADQIIKAFNGKLTQDsngnsfyeVDCN 257 Candida albicans
3TNE_B 196 A--LTISLASVNLKGSSF-------SFGDGAL-------LDSGTTLTYFPSDFAAQLADKAGARLVQVardqylyfIDCN 259 Candida parapsilosis
2ASI_A 274 SyQNSKSTISIVMqksgsssDTIEISVPVSKML--LPVDqs--neTCMFII-LPDGGNQYIVGNLFLRFFVNVYD-FGNN 347 Rhizomucor miehei
2APR_A 254 T--SAFKPLVFSI-------NGASFQVSPDSLV--FEEFq----gQCIAGF-GYGNWGFAIIGDTFLKNNYVVFN-QGVP 316 Rhizopus microsporus ...
5RBT_A 346 A---TLPSFTFGV-------GSARIVIPGDYID--FGPIstg-ssSCFGGIqSSAGIGINIFGDVALKAAFVVFNgATTP 412 chestnut blight fungus
P17946 321 T---NPPDFTVVI-------GDYKAVVPGKYIN--YAPIstg-ssTCFGGIqSNSGLGLSILGDVFLKSQYVVFN-SEGP 386 Aspergillus awamori
P32834 361 S-FSDSDYISFNFg------SDADFHVSVNDLV--IYRQestsgdICYLAL-FEGDTSSYLLGQYFLQYVYSIYD-WDAQ 429 Schizosaccharomyces p...
P22929 318 A---TGPDFKFSF-------NGKTITVPFSNLL--FQNSeg--dsECLVGV-LSSGSNYYILGDAFLRSAYVYYD-IDNS 381 Saccharomycopsis fibu...
P12630 324 V-SVGDVEYNFDF-------GDLQISVPLSSLI--LSPEte--gsYCGFAV--QPTNDSMVLGDVFLSSAYVVFD-LDNY 388 Saccharomyces cerevis...
1J71_A 256 --LSGDAVFNFD--------QGVKITVPLSELI--LKDSds---sICYFGI---SRNDANILGDNFLRRAYIVYD-LDDK 316 Candida tropicalis
3Q70_A 258 --LSGDVVFNFS--------KNAKISVPASEFAasLQGDdgqpydKCQLLF---DVNDANILGDNFLRSAYIVYD-LDDN 323 Candida albicans
3TNE_B 260 TdTSGTTVFNFG--------NGAKITVPNTEYV--YQNGd----gTCLWGI---QPSDDTILGDNFLRHAyLLYN-LDAN 321 Candida parapsilosis
2ASI_A 348 RIGFAPL 354 Rhizomucor miehei
2APR_A 317 EVQIAPV 323 Rhizopus microsporus var. chinensis
5RBT_A 413 TLGFASK 419 chestnut blight fungus
P17946 387 KLGFAAQ 393 Aspergillus awamori
P32834 430 KIGLAAL 436 Schizosaccharomyces pombe 972h-
P22929 382 QVGIAQA 388 Saccharomycopsis fibuligera
P12630 389 KISLAQA 395 Saccharomyces cerevisiae S288C
1J71_A 317 TISLAQV 323 Candida tropicalis
3Q70_A 324 EISLAQV 330 Candida albicans
3TNE_B 322 TISIAQV 328 Candida parapsilosis
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