1ZEB_A 34 KNLIIFLGDGMGVSTVTAARILKGQ-KKDK-LGPEIPLAMDRFPYVALS-K-TYNVDKHVPDSGATATAYLCGVKGNFQT 109 human Q24238 85 RNIIIFIGDGMGISTISAGRIYKGQyLKHG-YGEEETLVFDDFPNTGMA-K-TYNVDKQVPDSAGTATAIFSGSKTHYGA 161 fruit fly AAA30380 52 KNVIMFLGDGMGVSTVTAARILKGQ-LHHS-PGEETKLEMDKFPYVALS-K-TYNTNAQVPDSAGTATAYLCGVKANEGT 127 cattle EAW70991 71 KNLIIFLGDGMGVSTVTAARILKGQ-KKDK-LGPEIPLAMDRFPYVALS-K-TYNVDKHVPDSGATATAYLCGVKGNFQT 146 human NP_001037536 75 KNVVMFLGDGMSVPTLAAARTLLGQ-RRGQ-TGEEASLHFEQFPTLGLA-K-TYCVNAQVPDSSCTATAYLCGVKANQGT 150 domestic silkworm AAA18323 50 RNVIVMIGDGMGTPYIRAYRSMKN--NGDT-PNNPKLTEFDRNLTGMMMtH-PDDPDYNITDSAAAGTALATGVKTYNNA 125 Bacillus subtil... YP_004206516 44 KNVIVLIGDGMGVSYTSAYRYLKD---NKK-TKVVEPTAFDQYLVGQQTtY-PDDPEQNVTDSAAAATAMSAGIKTYNNA 118 Bacillus subtil... AAO17062 158 KNIILLIGDGMGDSEITAARNYAEG-AGGFfKGIDALPLTGQYTHYALN-KkTGKPDY-VTDSAASATAWSTGVKTYNGA 234 synthetic const... EGA62791 66 KNVIFFVTDGMGPASLSMARSFNQH--VND-LPIDDILTLDEHFIGS-S-R-TRSSDSLVTDSAAGATAFACALKSYNGA 139 Saccharomyces c... YP_001827450 42 RSVILLIGDGMGDAEITAARNYSVG-AAGR-LAMDTLDASGRRTTYAVD-E-RGRPVY-VTDSAAGATAWATGRRTVNGR 116 Streptomyces gr... Q94581 59 KNVILFLGDGMGVSTVTAGRILKGQ-IRGE-SGEETKLAMEQFPHAALS-K-TYSVNKQVADSASTATAYLCGVKTNYYT 134 Halocynthia ror... 3BDH_A 44 KNIILLIGDGMGDSEITAARNYAEG-AGGFfKGIDALPLTGQYTHYALN-KkTGKPDY-VTDSAASATAWSTGVKTYNGA 120 Escherichia coli
1ZEB_A 110 IGLSAaarfnqcnttR----------GNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWY----SDADVP 175 human Q24238 162 IGMDA----------Trskk---ngqQGRVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWE----CDTEVP 224 fruit fly AAA30380 128 VGVSAatqrsq----------cnttqGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWY----SDNEMP 193 cattle EAW70991 147 IGLSAaarfnq----------cnttrGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWY----SDADVP 212 human NP_001037536 151 PGVTAavprhdc--------eastdvTKRVQSIAEWALADGRDVGIVTTTRITHASPAGTFAKVANRNWE----NDNDVK 218 domestic silkworm AAA18323 126 IGVDKn--------------------GKKVKSVLEEAKQQGKSTGLVATSEINHATPAAYGAHNESRK------NMDQIA 179 Bacillus subtil... YP_004206516 119 IAVDNd--------------------GSEAKTVLEAAKEKGKATGLVATSEITHATPASFGSHDHSRK------NMNSIA 172 Bacillus subtil... AAO17062 235 LGVDIh--------------------EKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYgpsaTSEKCP 294 synthetic const... EGA62791 140 IGVDPh--------------------HRPCGTVLEAAKLAGYLTGLVVTTRITDATPASFSSHVDYRW------QEDLIA 193 Saccharomyces c... YP_001827450 117 VSKSHd-------------------tDRPMPTLLELARDRGYATGSVTTASVADATPAALTAHVTDRSCKgp-aDMAACP 176 Streptomyces gr... Q94581 135 IGLNA----------KvvynncqsskGNEVDSILVDSFKAGKSTGIVTTTQLGHATPGGAYAHSASRKWI----NDADLP 200 Halocynthia ror... 3BDH_A 121 LGVDI----------H----------EKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYgpsaTSEKCP 180 Escherichia coli
1ZEB_A 176 ASAR-Qe-G-CQDIATQLIS----N--MdIDVILGGGRKYMFRMGTPDP-----Eypd---dySQGGTRLDGKNLVQEWl 238 human Q24238 225 AESV-G--F-HVDIARQLVEnapgN--R-FNVILGGGMSPMGILNASEV-----KttifegptETICTRGDNRNLPAEWl 292 fruit fly AAA30380 194 PEAL-Sq-G-CKDIAYQLMY----NikD-IEVIMGGGRKYMFPKNRTDVeyeldE--------KARGTRLDGLNLIDIWk 257 cattle EAW70991 213 ASAR-Qe-G-CQDIATQLIS----N--MdIDVILGGGRKYMFRMGTPDP-----Eypd---dySQGGTRLDGKNLVQEWl 275 human NP_001037536 219 QEGH-DvnR-CPDIAHQLIKmapgN--K-FKVIFGGGRREFLPTTQVDE-----E--------GTRGLRTDGRNLIEEWq 280 domestic silkworm AAA18323 180 NSYM------DDKIKGK-------H--K-IDVLLGGGKSYF---------------------------NRKNRNLTKEF- 215 Bacillus subtil... YP_004206516 173 DDYF------DEMVNGK-------H--K-IDVLLGGGKSNF---------------------------DRKDRNLIKEF- 208 Bacillus subtil... AAO17062 295 GNAL-Ek-GgKGSITEQLLN----A--R-ADVTLGGGAKTFAETATAGE--------------------WQGKTLREQA- 344 synthetic const... EGA62791 194 THQL----G-EYPLGR-----------V-VDLLMGGGRSHFYPQGEKAS-----Py-------GHHGARKDGRDLIDEA- 243 Saccharomyces c... YP_001827450 177 ADTRaGg-G-EGSIAEQTVA----A--R-PDVLLGGGADHFAQTVTDGP--------------------FRGRTVTQQA- 226 Streptomyces gr... Q94581 201 DEAK-En-E-CRDITRQFYDn--sH--M-ITVALAGGRADMIPVTSRDP-----Ey------sDQSGKREDGMNLINMWk 261 Halocynthia ror... 3BDH_A 181 GNAL-Ek-GgKGSITEQLLN----A--R-ADVTLGGGAKTFAETATAGE--------------------WQGKTLREQA- 230 Escherichia coli
1ZEB_A 239 ----aKRQGARYVWNRTELMq---AS-LDPSVTHLMGLFEP--------------------GDMK--------------- 275 human Q24238 293 ahhanDTVPPALVHNRKDLL----NV-NVKKVDHLMGLFRN--------------------NHIT--------------- 332 fruit fly AAA30380 258 sf-kpKHKHSHYVWNRTDLL----AL-DPHSVDYLLGLFEP--------------------GDMQ--------------- 296 cattle EAW70991 276 ----aKRQGARYVWNRTELMq---AS-LDPSVTHLMGLFEP--------------------GDMK--------------- 312 human NP_001037536 281 ndkesQKVSYKYLWNRQELL----KL-GSSPPDYLLGLFEG--------------------SHLQ--------------- 320 domestic silkworm AAA18323 216 -----KQAGYSYVTTKQALK----K----NKDQQVLGLFAD--------------------GGLA--------------- 247 Bacillus subtil... YP_004206516 209 -----KKAGYSYVDDRKDML----K----NKDSQVLGLFAD--------------------GGLP--------------- 240 Bacillus subtil... AAO17062 345 -----QARGYQLVSDAASLN----SVtEANQQKPLLGLFAD--------------------GNMPvrwlgpkatyhgnid 395 synthetic const... EGA62791 244 -----QSNGWQYVGDRKNFDsllkSH-GENVTLPFLGLFAD--------------------NDIP--------------- 282 Saccharomyces c... YP_001827450 227 -----RAAGYQVVRDRTQLA----A---ARPGRPVLGLFAPeyvpvewtgppaapggtapqRCAT--------------- 279 Streptomyces gr... Q94581 262 kkmhdNGFEPAYVWNKTEFR----NV-NVEKTDRLLGLFEP--------------------MNMQ--------------- 301 Halocynthia ror... 3BDH_A 231 -----QARGYQLVSDAASLN----SVtEANQQKPLLGLFAD--------------------GNMPvrwlgpkatyhgnid 281 Escherichia coli
1ZEB_A 276 -------YEIHR-D---STlDPSLMEMTEAALRLLS------RN-------PRGFFLFVEGGRIDHGHHESRAYRALTET 331 human Q24238 333 -------YSIAR-E---AG-EPSLQEMTETALGILE------RGd-----eSNGFVLLVEGGRIDQGHHMNYARAALHEL 389 fruit fly AAA30380 297 -------YELNRnN---AT-DPSLSEMVEMAIRILN------KN-------PKGFFLLVEGGRIDHGHHEGKAKQALHEA 352 cattle EAW70991 313 -------YEIHR-D---STlDPSLMEMTEAALRLLS------RN-------PRGFFLFVEGGRIDHGHHESRAYRALTET 368 human NP_001037536 321 -------YHLEG-De--ST-EPTLAELTDVAIRVLS------RN-------ERGFFLFVEGGRIDHAHHDNYAHLALDET 376 domestic silkworm AAA18323 248 -------KALDR-D---SK-TPSLKDMTVSAIDRLN------QN-------KKGFFLMVEGSQIDWAAHDNDTVGAMSEV 302 Bacillus subtil... YP_004206516 241 -------KKIDR-T---KD-IPSLKDMTNTAIKKLN------KD-------KDGFFLMVEGSQIDWAGHDNDIVGAMSEM 295 Bacillus subtil... AAO17062 396 kpavtctPNPQR-N---DS-VPTLAQMTDKAIELLS------KN-------EKGFFLQVEGASIDKQDHAANPCGQIGET 457 synthetic const... EGA62791 283 -------FEIDR-De--KE-YPSLKEQVKVALGALEkasnedKD-------SNGFFLMVEGSRIDHAGHQNDPASQVREV 344 Saccharomyces c... YP_001827450 280 -------RNPGR-P---AG-TPDLAESTRAALDLLT------ARahhrgapGRGFFLQVEGASIDDRAHEADPCGQLGET 341 Streptomyces gr... Q94581 302 -------YDANR-LkdgSG-EPSLAEMTEKAIQILQ------KN-------TNGYFLLVEGGRIDHGHHSNAAYLALHDV 359 Halocynthia ror... 3BDH_A 282 kpavtctPNPQR-N---DS-VPTLAQMTDKAIELLS------KN-------EKGFFLQVEGASIDKQDHAANPCGQIGET 343 Escherichia coli
1ZEB_A 332 IMFDDAIERAGQLTS--EEDTLSLVTADHSHVFSFGGYPLRGS-SIFGLAPGk-----ARDRKAYTvLLYGNGPGYVL-- 401 human Q24238 390 YEFDLAIQAAVNNTD--PDETLILVTADHSHAVTFNGYALRGA-DILGTANSh----eKNDPMFYEtISYANGPGYWD-- 460 fruit fly AAA30380 353 VEMDQAIGQAGAMTSv-ED-TLTVVTADHSHVFTFGGYTPRGN-SIFGLAPmv----sDTDKKPFTaILYGNGPGYKVv- 424 cattle EAW70991 369 IMFDDAIERAGQLTS--EEDTLSLVTADHSHVFSFGGYPLRGS-SIFGLAPg-----kARDRKAYTvLLYGNGPGYVL-- 438 human NP_001037536 377 IEMDRAVKVATDALK--EDESLVVVTADHTHVMSFNGYSPRGT-DVLGTVRs-----lDSNRMPFMvLSYTNGPGARI-- 446 domestic silkworm AAA18323 303 KDFEQAYKAAIEFAKk-DKHTLVIATADHTTGGFTIGANGEK---NWHAEPi-----lSAKKTPEF-MAKKISEGKPV-- 370 Bacillus subtil... YP_004206516 296 EDFEQAYKAAIDFAKk-DKHTLVVATADHSTGGYSIGADGIYN---WFSEPi-----kAAKRTPDF-MAEKIADGADVek 365 Bacillus subtil... AAO17062 458 VDLDEAVQRALEFAKk-EGNTLVIVTADHAHA-------------SQIVAP-------DTKAPGLT-QALNTKDGAVM-- 513 synthetic const... EGA62791 345 LAFDEAFQYVLEFAEnsDTETVLVSTSDHETGGLVTSRQVTASyPQYVWYPqv---laNATHSGEF-LKRKLVDFVHEh- 419 Saccharomyces c... YP_001827450 342 LAFDRAVAAALDHAEr-HPRTLVIVTADHGHA-------------TQILPH-------DARPAGLS-ATLVTDEGGVM-- 397 Streptomyces gr... Q94581 360 VAFDDAIEKAVEMTS--EDDTLIIATADHSHVFTMGGYSDRGN-DIFGIAPSgnspdlAEDNKPYTtLLYGNGPGYNG-- 434 Halocynthia ror... 3BDH_A 344 VDLDEAVQRALEFAKk-EGNTLVIVTADHAHA-------------SQIVAP-------DTKAPGLT-QALNTKDGAVM-- 399 Escherichia coli
1ZEB_A 402 -K--------------D--GARPDV--TESESGSPEYRQQSAVPLDEET----------------------------HAG 434 human Q24238 461 -Hlands-----rpqnSsnMWMPLKhfTAEERAAPTYRHLATVPRKDET----------------------------HGG 506 fruit fly AAA30380 425 ------------------gGERENV--SMVDYAHNNYQAQSAVPLRHET----------------------------HGG 456 cattle EAW70991 439 -K--------------D--GARPDV--TESESGSPEYRQQSAVPLDEET----------------------------HAG 471 human NP_001037536 447 ----------------QqnGVRPDVt-TDANFGALRWRTHTDVPLDSET----------------------------HGG 481 domestic silkworm AAA18323 371 -K--------------DvlARYANLkvTSEEIKSVEAAAQADKSKGASKaiikifntr----------snsgwtstdHTG 425 Bacillus subtil... YP_004206516 366 tL--------------KtyIDQKKLalTKAEIQSVEEAAKSKEVLDIDNaienifnkr----------shtgwttggHTG 421 Bacillus subtil... AAO17062 514 ---------------------------------VMSYGNS---EEDSQE----------------------------HTG 529 synthetic const... EGA62791 420 kG--------------AssKIENFIkhEILEKDLGIYDYTDSDLETLIHlddnanaiqdklndmvsfraqigwtthgHSA 485 Saccharomyces c... YP_001827450 398 ---------------------------------QLGYG--TALPGETQE----------------------------HTG 414 Streptomyces gr... Q94581 435 -HyridsrnyvfpilnRsqAKRKNL--TKIDTTRPDYVQQTAVPTDSET----------------------------HGG 483 Halocynthia ror... 3BDH_A 400 ---------------------------------VMSYGNS---EEDSQE----------------------------HTG 415 Escherichia coli
1ZEB_A 435 EDVAVFARGPQA-------HLVHGVQEQTFIAHVMAFAACLE 469 human Q24238 507 EDVAVFAYGPGS-------SLIRGVFEQNYLAYVMSYAGCLG 541 fruit fly AAA30380 457 EDVAVFAKGPMA-------HLLHGVQEQNYIPHVMAYAACIG 491 cattle EAW70991 472 EDVAVFARGPQA-------HLVHGVQEQTFIAHVMAFAACLE 506 human NP_001037536 482 DDVTVFAWGVHH-------WMFSGLYEQTHVPHRMAWAACMG 516 domestic silkworm AAA18323 426 EEVPVYAYGPGK-------EKFRGLINNTDQANIIFKILKTG 460 Bacillus subtilis subsp. subtilis str. JH642 YP_004206516 422 EDVPVYAYGPSS-------ETFAGQIDNTEIAKNVFKALQYN 456 Bacillus subtilis BSn5 AAO17062 530 SQLRIAAYGPHA-------ANVVGLTDQTDLFYTMKAALGLK 564 synthetic construct EGA62791 486 VDVNIYAYANKKatwsyvlNNLQGNHENTEVGQFLENFLELN 527 Saccharomyces cerevisiae FostersO YP_001827450 415 VPVPVAARGPLA-------DRVRGVQDNTSLFGTVTAALGLR 449 Streptomyces griseus subsp. griseus NBRC 13350 Q94581 484 EDVAIFARGPMA-------HLFHGTHEQNYIAHVMRYVSCVG 518 Halocynthia roretzi 3BDH_A 416 SQLRIAAYGPHA-------ANVVGLTDQTDLFYTMKAALGLK 450 Escherichia coli
Jiyao W et al.(2023). "The conserved domain database in 2023.",