Conserved Protein Domain Family
DUF4401
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pfam14351: DUF4401 
Domain of unknown function (DUF4401)
This family of proteins is found in bacteria. Proteins in this family are typically between 357 and 735 amino acids in length. The family is found in association with pfam09925. There is a single completely conserved residue K that may be functionally important.
Links
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Statistics
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PSSM-Id: 433893
Aligned: 26 rows
Threshold Bit Score: 98.9397
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9CM56         289 TWHIYPLFILLIIFCTGLLLITLFFSfgLEDE--------QDLIYPSILFLIIALVMHFnQKEKADWFDIAIDMFMAT-- 358 Pasteurella m...
WP_013744086   325 PWYFSLLRITIMGLAAILVIAFLFVTldLEYE---------QLWVIGLVVCGLGLLALR--SGGSIMGEFGTTLTVAG-- 391 Pusillimonas ...
jgi:Ddes_1650  418 PWYVRLLLALGGWLAAILFVCFLAFFvfETMQiiayeeagIFIASIPVLLLGRSMLVKN----TIFSRHFGFALAITG-- 491
LANL:CH63_3201 394 PWYIRTAFAFGGWIAALILLALLILL--GFVSgmfdnlnaGTIIVVSLIGGAFAAFLLT--RPGMGIQQIGLVWAIAS-- 467
WP_015699229   394 PWYLRLTLSIGGWVAAMIILFLLILV--LYVAdllndpnaATVIIPSLLLAAVAGGLLR--MQGVSKHHIGLAWAIAA-- 467 Rahnella aqua...
Q8A6Q3           6 nLTIEVLSIIGGVLTAIFFLGFLVLS--SILRs------eTSCLITGSILIITTLFVNR-LLTKPFLDAMNITCYIAG-- 74  Bacteroides t...
WP_014032630    42 sLAIKILSALGGILASSAFIVVLFLL--DVLDs------eWSSIILGIVLIGTAIGINK-KYETLIIDTFSVSIYVLG-- 110 Muricauda rue...
EHQ44362        36 yvFLKVVAILGSLLAMGFFFGFLFLTigDSLGy-------ISFLLFGVVLYALSFIGNK-KTEPALRDGVFVATYISAfv 107
WP_011759590    29 PLWLTLLTGLSGWIAAFFFLGFSVLLieEFSRfd-----dKMALAVGLIYAAIARGIYSqGKGVEFLTQLGFAINLAA-- 101 Shewanella am...
jgi:Haur_1252   33 PWYMRIFAGIGAWFAAFMFLGFLAIT--NIITn------eFGALVVGLGLCAVAIGINRtNQASTFLRQLALAISITG-- 102

Q9CM56         359 ---GFILYFIFFLFDGENDLy-----LALMAILSVFLYQLRSSNWLRF-----LIASLFiiaflvy--igffdlrWYAYY 423 Pasteurella m...
WP_013744086   392 ---LFMTGVGLFDLNEIGSFs----rAGGIVLMGLAVYCLATGAALRF-----LCAFFV----------------LVLAY 443 Pusillimonas ...
jgi:Ddes_1650  492 ---TVGMSISMFLTVNSFMSa-----CFLLALLLVVVSSLMQTPPYTF-----LAAMTVva------------avSFGTS 546
LANL:CH63_3201 468 ---SIGLYSGIILIQDSSSRlml-mqSLWFIPVLAVLIVVFHNDMYRF-----LATGTLvf------------msIVTTS 526
WP_015699229   468 ---TCGLCFGFYLLFEPGWEmsvlvgSLCSLPVLAAMALAMRDHAYRFmaitaLTFLLIl--------------tGNLLA 530 Rahnella aqua...
Q8A6Q3          75 ---CILAGYGMNRNMDVL--------FIVLIGISVVTMLLSKGFILTF-----LSVISFym-------------aLFGEI 125 Bacteroides t...
WP_014032630   111 ---LILFILGMAMHHNVQEGh----iAFLIVLIALSSLFFTQNYVISF-----ISVLAI----------------GASFL 162 Muricauda rue...
EHQ44362       108 cviAAGIDFGWRESNN----------LLSVIVLSFGGFMLFKSKIIQF-----LSLIGL------------------YYG 154
WP_011759590   102 ---MLATLWGLAHYFDN---------PGVVYWLSGACLLALNGWFCRYgvdgqLSVLGA--------------------- 148 Shewanella am...
jgi:Haur_1252  103 ---QALVLFGWTIIVESVIVa-----ALGMIVLEIALFVAHRDFSQRL-----ISTLGVitaihviagdlnnwveSFNYM 169

Q9CM56         424 EEHLGQFVLSAQQWiiLGGLLlyyFFS------------------LSEERPYTIKLLPIAWAm----------------- 468 Pasteurella m...
WP_013744086   444 QLTWPDYLDAMPLDllDGGSAstlAYFpaylrlwwlavaavlalvVAQRAGKQAFWLPLAWAlv---------------- 507 Pusillimonas ...
jgi:Ddes_1650  547 SLVFEELGQW-----------------------------------QVESLGKIIFYLPLIWWaav--------------s 577
LANL:CH63_3201 527 YALIWHLAPDNQQLffFIPILivtVIVmlilwl-------icneiKLLATVNAPLIHPLMYG------------------ 581
WP_015699229   531 GLFLSPIAGLGAVStlVACVVifwLWVire-------------qlNLKARPVTDAVFPLLYGipa--------------- 582 Rahnella aqua...
Q8A6Q3         126 TNLFSSLNPLNVAAvpIIAIFlfvNLSetk------------ilsYTN--GDLSKYKPIHSGlfv--------------s 177 Bacteroides t...
WP_014032630   163 FLIISYHIPDAIHGyvLFYATalsYCFlne------------asfLTAHPKLAKLYGPLRIGlif--------------s 216 Muricauda rue...
EHQ44362       155 LVYYLGFIHLGYGAllLFWLLlvgLYFmfdk----------evelKTKYSFWSQRYNAILNAlflifffeiiqdnis--- 221
WP_011759590   149 LVLFAQAFDSVKCVawVLPAMllgLGLvnglw---------qpwiRLQLCGLHLFARRLSHGmvfmvlalplvldeqlly 219 Shewanella am...
jgi:Haur_1252  170 YLLLSVMIISFSLLmwFEA--------------------------KIHEDQRWSSASPIAYGmll--------------f 209

Q9CM56         469 -LLVGLAMNLDifnrwtfldtaqqtpemsdlndwfhvitgyffTALTSDTWLIKSLHLLISITPIIFfv----------- 536 Pasteurella m...
WP_013744086   508 cLTQAAAWLAPaptvlgl-------------------dgvtqqAPGLLVIWLACALLPVLSLAALMW------------- 555 Pusillimonas ...
jgi:Ddes_1650  578 lGLARFCLHEKtwrgr-----------------------gtspNADAWFFGAYAGMLICQLASLGIWqqfmlpfpalrga 634
LANL:CH63_3201 582 --------------------------------------------GIGGILVVCLHSIQMGNIHEFYWmsdrglyleqsls 617
WP_015699229   583 ---------------------------------------------------glVLLCFCGINAPFFYdlfwhpagyfvls 611 Rahnella aqua...
Q8A6Q3         178 cVLSLAGLSVN------------------------------------YLTKSTNDWI----ISVFMLvgillm------- 210 Bacteroides t...
WP_014032630   217 lLFGLVVIGKN------------------------------------GLVPISKNLIWMSSVASFFFilyla-------- 252 Muricauda rue...
EHQ44362       222 -----------------------------lidpsnwinrsrffDYHVVGHRIYLGFVGIVLIVLTYWtik---------- 262
WP_011759590   220 lGAGSIFAGQD--------------------------------GWAFSIAKAASYLTFIIFCAAILW------------- 254 Shewanella am...
jgi:Haur_1252  210 mAISSLLINFNwa-----------------------------eFFSRGSFFILPALVGIICLGTTIWmi----------- 249

Q9CM56         537 -------------------liSRRFELTKFLYASVLLTLLA----LCLGFIAVNETLACISLLLLAYLSVSRVLFALALL 593 Pasteurella m...
WP_013744086   556 ----------------------RAGHVPRWLSVSAPLALAV----ASLGWLGAPGVSMALLWLVLAYAMGQRALLVFAVL 609 Pusillimonas ...
jgi:Ddes_1650  635 yg-----mgmgaalgigylaiSLSRKRHGFARAGVLLAAAA----SFVLAWHLPGAALALLGLALARQMTNMAMQGFVLT 705
LANL:CH63_3201 618 yg----ipaafllftliqwvlHRSKLKPLWLIAAVVTSLA---------AYFAPGMGFGLALLLIARYQGNQWLLGVAAS 684
WP_015699229   612 sgtgtgiaaglilgslyqvitKRTPPVPLLFVAAIFCGTAA---------FYAPGIGLGMWLLLMARYQGRQGVLAASGC 682 Rahnella aqua...
Q8A6Q3         211 ---------------vykivqVMQVKSPVHQVCIYLLCILI----CFP-SLHAPYLSGSILLILICFQYGYKAESAVALL 270 Bacteroides t...
WP_014032630   253 ----------------shvlrTLQVRSTKNKWAAYVLCFLT----LLP-TLFAPAISGALLIVLLSFLVNHKTGLGVGIV 311 Muricauda rue...
EHQ44362       263 -------------------qiGQRVTLPQPLLITGISSVVIlgmaFFMHGFGMP-LVVSFFLLVWSFQFRFYKGIVLAIC 322
WP_011759590   255 ------------------------------RLKVPVLGLVMgtlgLTLLFSQFSGLALAMVLWLFGWQRRERLYVLLASM 304 Shewanella am...
jgi:Haur_1252  250 -------------------inEFEYKLGFIELGCIAFGLLF----IAFAGINTPAIIIALLIILLSYWRGYPVMFGFGCL 306

Q9CM56         594 GVIMNLSYYYYLLSIPLLHKSFLLMGVGIVLALVTFVLLRY 634 Pasteurella multocida
WP_013744086   610 SLLAYLSRFYYQMDATLLQKSLVLGLTGGWLLLSWFALRak 650 Pusillimonas sp. T7-7
jgi:Ddes_1650  706 YLLAYMIFYYYTLAVPFAAKALYLTATGIVLLLLALSLRTW 746
LANL:CH63_3201 685 FLAVYTSGWYYFLGFSLLYKSLLLIGGGVLLLVLAGVLNRV 725
WP_015699229   683 ILTLYIIDWYYFLGVSLLQKSLLLFATGAGLLVLAFAAQKw 723 Rahnella aquatilis
Q8A6Q3         271 LFIYSISKYYYDLDITLLTKSITLFFTGIALLIAWYIFTQK 311 Bacteroides thetaiotaomicron
WP_014032630   312 ALVYFVSQYYYDLNLSLLTKSIVLFSSGVVFLVFYLFFTKK 352 Muricauda ruestringensis
EHQ44362       323 TLLLSLGAYYYYLNVSLLIKSLILMGCGLFFLGLFVIYNRW 363
WP_011759590   305 AALLYFSAYYYELSLTLLHKSMVLMGLGILLLLAGFVLSRR 345 Shewanella amazonensis
jgi:Haur_1252  307 ALIGALSLYYYNLNISLLYKSIILFGTGMMLLAIRALVLKL 347
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